Y. Shi

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study shows that PTP1B inactivation disrupts miR-208b-Argonaute 2 interaction, leading to increased THRAP1 expression and thyroid hormone-induced cardiac hypertrophy.

The paper performs single-cell RNA sequencing on TNBC tumors to identify novel immune cell subsets and their associations with survival and TCR signaling.

This paper develops an automated 3D analysis framework for OCTA data to better characterize retinal vessel networks in diabetic retinopathy compared to healthy controls.

The paper identifies antitumor drugs that modulate pre-mRNA splicing through a screening assay, revealing new therapeutic applications and SF3B1 antagonists.

This study reports cryo-EM structures of two late-stage human spliceosomes, revealing insights into exon release and spliceosome disassembly mechanisms.

This study investigates the mutational features of aristolochic acid-induced liver cancers in mice and humans, identifying characteristic A>T transversions and recurrent mutations in key cancer-related genes.

The paper determines cryo-EM structures of yeast spliceosome B* complexes to elucidate the mechanism of the branching reaction during pre-mRNA splicing.

This study shows niacin reduces body weight and fat mass via GPR109A-dependent pathways, improving energy homeostasis in mice.

This study identifies protective monoclonal antibodies against ricin by mapping their epitopes using HX-MS and shows that specific contact points on RTA correlate with in vivo protection.

The paper mutates nine residues in the Suvratoxumab epitope of alpha toxin, showing reduced lytic activity and bacterial fitness, supporting the epitope's role in toxin function.

This study differentiates dermal mesenchymal stem cells into vascular endothelial cells using endothelial cell line conditioned medium, showing high CD31 expression and angiogenic ability.

The paper determines the cryo-EM structure of a human polyadenylation complex bound to AAUAAA RNA, revealing how this signal is recognized by CPSF-30 and WDR33.

This study identifies the role of N-linked glycosylation in ZIKV E protein function across mosquito and human cells using a mutant library.