Y. Sun

This study demonstrates that micropatterned human pluripotent stem cells self-organize into distinct midbrain and hindbrain/spinal cord regions, revealing a novel regulatory mechanism for AP patterning.

This study evaluates a linear DNA vaccine in domestic cats, showing it is safe and induces immune responses against SARS-CoV-2.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study identifies stromal transdifferentiation of fibroblasts into adipocytes as the driver of lymph node lipomatosis, leading to vascular remodeling and immune dysfunction in aging.

The paper shows the ubiquitin-proteasome system targets proteins inside chloroplasts, including chloroplast-encoded photosynthesis subunits, via the CHLORAD pathway.

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

This study develops a chitosan hydrogel reinforced with cellulose and allograft to improve spinal fusion, showing enhanced compressive strength, biocompatibility, and osteoinductive properties in vitro and in vivo.

This paper identifies a new class of TEAD-YAP inhibitors with a novel binding mode that suppresses transcriptional activity and shows anti-proliferative effects in cancer cells.

The paper identifies an immunoregulatory subtype of lymphatic endothelial cells that drives lymphatic malformations through pro-inflammatory signaling and immune cell interactions.

The paper investigates m6A-mediated regulation of flavor metabolites in tea leaves during solar-withering, identifying key m6A erasers and their impact on terpenoid and flavonoid biosynthesis.

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

This paper develops a prefusion-stabilized Lassa virus GPC, identifies a neutralizing nanobody, and reveals a cleavage-dependent site of vulnerability at the trimer apex.

This study analyzes methicillin-resistant M. caseolyticus isolates from retail meat and GenBank, revealing geographic lineage distribution, antimicrobial resistance, virulence factors, and morphological differences.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

This paper uses a graph neural network to predict task-evoked fMRI responses from structural connectome data, revealing the importance of ipsilateral cortical regions for higher cognitive functions.

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study reports the cryo-EM structure of the wheat CNL Sr35 resistosome and shows its structural and functional conservation with the Arabidopsis ZAR1 resistosome.

This study uses cryo-electron tomography to reveal the 3D organization of Rubisco in two types of carboxysomes from different bacteria, showing distinct structural arrangements and responses to calcium treatment.

This study compares the effects of immunomodulatory BT peptide and antibiotics on cecal microbiota in broilers challenged with Clostridium perfringens, finding differences in microbial composition and function.

The paper describes the purification of a viral reference database (EVRD) by removing contaminating sequences, improving accuracy and efficiency in viromic analysis.

This study uses single-particle cryo-EM to determine the structure of a native α-carboxysome from a marine cyanobacterium, revealing its shell architecture and internal enzyme organization.

This study evaluates factors affecting the qualification rates of standardized internal medicine residency training in China, identifying regional origin and training duration as independent predictors.

The paper uses super-resolution microscopy and a fluorescent probe to analyze lysosome spatial organization relative to mitochondria, revealing changes in distance distribution patterns during autophagy and linking lysosome positioning to mitochondrial health.

This study develops PCR-produced DNA amplicons as a cancer vaccine strategy, showing they elicit immune responses and reduce tumor growth when combined with immune-checkpoint inhibitors.

The paper shows that natural mutations in human H3N2 HA influence the egg-adaptation pathway, affecting mutation emergence during vaccine production.

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

This study identifies Rmt5 as a critical regulator of Cryptococcus neoformans morphology and virulence by characterizing its interactome and phenotypic effects.

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

This study evaluates the effectiveness of a disinfectant combining highly complexed iodine and compound organic acids in inactivating African swine fever virus under various conditions, showing dose- and time-dependent inactivation with synergistic effects.