Y. Tan

This study identifies Lem8, a protease effector from Legionella pneumophila, which inhibits host cell motility by targeting Phldb2 via 14-3-3ζ-dependent activation.

The paper investigates whether pheromones from different eusocial insects induce similar transcriptomic responses in a solitary insect model, finding conserved physiological but divergent transcriptomic responses.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study identifies genomic changes and novel toxins in Liberibacter pathogens through comparative phylogenomic analysis, linking prophage loci and gene gains/losses to pathogenicity.

This study determines the cryo-EM structure of the 5-HT1F receptor complex with lasmiditan and a G protein, revealing the mechanism of selective activation and informing drug design.

This study deletes SOD2 in skeletal muscle of adult mice and finds no major metabolic impairment but altered lipid metabolism and mitochondrial abundance.

The paper identifies metabolic reprogramming in platinum-resistant cancer cells from glycolysis to fatty acid uptake and beta-oxidation, showing a correlation with resistance and proposing a treatment strategy.

This study compares the immunogenicity of spike proteins from Alpha- and Beta-coronaviruses, finding that Beta-CoVs induce stronger neutralizing antibodies against RBD than Alpha-CoVs.

This study develops a drug-resistant recombinant BCG vaccine that enhances second-line TB treatment efficacy in a murine model of drug-resistant tuberculosis.

This study unifies M/ORF3-related proteins across coronaviruses and other nidoviruses, revealing their conserved role in ion conductance and virion assembly, while showing differential evolutionary pressures between M and ORF3 proteins.

This study uses iTRAQ proteomics to identify 20E and PLC inhibitor-regulated proteins in Apolygus lucorum, revealing shared and distinct DEPs and their involvement in metabolic and signaling pathways.

This study uses phylogeographic and phylodynamic methods to test hypotheses about West Nile virus dispersal and genetic diversity, finding temperature influences on spread and no strong evidence for migratory bird flyway restriction.

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

The paper uses centromere-specific antibodies to karyotype Okinawan Oikopleura dioica and finds three pairs of chromosomes, consistent with Atlantic populations.

This study shows that inactivating Pak2 reduces tumor development in Nf2-deficient mice, suggesting PAK inhibition could be a therapeutic strategy for NF2-deficient cancers.

This study investigates the role of ESR1-CCDC170 gene fusions in breast cancer endocrine resistance, showing they reduce endocrine sensitivity and can be targeted with HER2/SRC inhibitors.

This study shows that human limbal niche cells in 3D Matrigel can induce dedifferentiation of mature corneal epithelial cells into a progenitor state.

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

The paper identifies FZD7 as a marker of platinum-tolerant ovarian cancer cells that are susceptible to ferroptosis via the FZD7-β-catenin-Tp63-GPX4 pathway.

This paper demonstrates genetic engineering of liver organoids to enhance maturation and functionality through CRISPR and transcription factor overexpression.

This paper uses machine learning to identify motion features for evaluating rehabilitation progress in stroke patients, finding that movement smoothness is the best measure.

The paper modifies phosphorylation sites of the Cre1 transcription factor in Trichoderma reesei to enhance cellulase production under glucose repression.

This study identifies novel Ig domain proteins in SARS-related coronaviruses, highlighting their rapid evolution and potential role in pathogenesis.

The paper introduces DPSN, a database that standardizes short names of amplicon-sequencing primers to reduce ambiguity and improve communication.

This study improves subspecies identification of Mycobacterium abscessus complex using whole genome sequencing by developing a method based on rpoB, erm(41), and rpls genes, achieving 100% accuracy in public and clinical isolates.

This study characterizes mucosal dysbiosis in early colonic neoplasia, finding associations between specific bacterial species and colorectal cancer mutations.

The paper profiles the fitness landscape of HIV-1 protease resistance mutations and finds that positive epistasis is predominant, reducing the likelihood of reversing drug resistance mutations.

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.