Y. Wang

The paper identifies KCRs, light-gated potassium channels from a fungus-like protist, which are highly selective and fast-acting, showing potential for optogenetic control of potassium gradients in neurological and cardiac diseases.

This study identifies SLC25A39 as a mitochondrial glutathione importer and shows its role in cell proliferation and red blood cell development, with GSH availability regulating its abundance.

This study shows drought reduces sucrose transport from cottonseed coat to fiber and disrupts sucrose allocation, leading to decreased cellulose synthesis and fiber strength.

This study shows that adding a C-terminal tail to the tailless murine GnRHR impairs fertility by reducing FSH production and ovarian follicle development.

The paper identifies CDC20 missense variants linked to familial cancer, showing they impair SAC binding and promote mitotic slippage.

The paper detects Phytophthora cinnamomi in Carya cathayensis using loop-mediated isothermal amplification and confirms its association with dieback disease.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

The paper uses long-read sequencing to assemble a complete tomato genome, revealing linkage drag from a wild species during breeding.

The paper shows that PFOR supports aerobic photomixotrophic growth in cyanobacteria by utilizing ferredoxin instead of NAD(H), saving Gibbs free energy and decelerating metabolism.

This study investigates how mechanosensitive channels and cell wall integrity signaling interact during pollen germination in Arabidopsis thaliana, revealing their roles in callose deposition and cell integrity.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

The paper identifies how EPS1, a BAHD acyltransferase, evolved to catalyze a unique lyase reaction in SA biosynthesis in Brassicaceae plants through active site reconfiguration.

This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.

This paper introduces SMOG 2 and OpenSMOG, extending structure-based models to handle large biomolecular systems with enhanced customization and integration with OpenMM.

This study develops a murine model of CNS-TB using Nos2-/- mice infected with M. tuberculosis, showing neurobehavioral changes and immunopathology similar to human CNS-TB.

The paper predicts conserved T-cell epitopes in SARS-CoV-2 variants using computational methods to identify antigenic peptides that could be used in vaccines.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

This study profiles the transcriptome of Candidatus Liberibacter asiaticus in citrus and psyllids, identifying gene expression patterns and differentially expressed genes between hosts.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

This study shows that heme activates platelet TLR4 signaling, leading to mitochondrial ROS production and targeted granule secretion, with implications for thrombo-inflammatory responses.

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

This study identifies two potent monoclonal antibodies against the B.1.351 variant and shows their efficacy against other variants, suggesting their use as an antibody cocktail.

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper shows that disordered spring climate disrupts migration and breeding of a short-distance fish, leading to population decline and larval flux reduction.

The paper determines the cryo-EM structure of the chloroplast ClpP complex and shows how the co-chaperonin inhibits its proteolytic activity.

This study shows SORL1 regulates endosomal recycling in neurons by affecting APP, TRKB, and GLUA1 trafficking, with implications for Alzheimer's disease.

This study shows SARS-CoV-2 exploits sex-specific IFN and TNFα signaling to enhance ACE2 and TMPRSS2 expression in male alveolar cells, promoting viral entry and suggesting potential therapeutic targets.