Y. Wang

The paper introduces Yn situ, a single RNA molecule in situ detection method, showing it is sensitive and quantitative for gene expression in mouse olfactory epithelia.

This paper adapts base editors for precise gene editing in citrus, achieving transgene-free resistance to pathogens and herbicides.

The paper uses cryo-ET to identify structural changes in platelets during pre-acute myeloid leukemia, suggesting these changes could serve as an early diagnostic biomarker.

This study shows that disrupting Golgi structure by knocking out GRASP55 and GRASP65 alters glycosaminoglycan synthesis, sulfation, and secretion.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study identifies CD20+ T cells as inflammatory contributors in murine arthritis, showing their expansion and cytokine production in lymph nodes and joints.

This study shows that flagellin FLiC enhances upland cotton resistance to Verticillium dahliae by inducing immune responses and modulating calcium, hydrogen peroxide, and nitric oxide pathways.

This study develops 3D human brown adipose microtissues that improve glucose and insulin homeostasis in obese and diabetic mice.

This study shows GRASP55 promotes mutant huntingtin secretion via autophagy and stress conditions, reducing aggregation and toxicity.

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

This paper presents a model showing how cancer treatments can induce stemness, leading to tumor recurrence, and suggests optimizing dosing to avoid this.

The paper develops FAST, an improved gene-interfered ferroptosis therapy that shows enhanced antitumor activity and tumor eradication compared to its predecessor GIFT.

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

The paper identifies TOP1 inhibitors as therapeutic agents for neuroinflammation and develops a DNA origami nanosystem for targeted delivery to myeloid cells.

This study identifies ARNO as a key regulator linking cell migration and inflammation in synovial fibroblasts, showing its role in promoting migration and modulating cytokine profiles in response to IL-1β.

This paper introduces a two-color super-resolution microscopy method using an RGBW camera and joint encoding of emitter location and color, achieving ~20 nm resolution and <2% crosstalk.

This study investigates how cockroaches adjust their body and appendages to traverse cluttered obstacles, finding that leg sprawl reduction significantly lowers the energy barrier for locomotor transitions.

This study shows the Nrf2/Keap1 axis is activated by EIAV-Rev, leading to antiviral effects through two mechanisms: enhancing antioxidant defenses and inhibiting Rev-mediated RNA transport.

The paper identifies 2-isobutylmalate synthase (IBMS) as a novel enzyme related to IPMS that catalyzes the synthesis of 4-methylvaleric acid, a precursor of pogostone.

The paper uses AI-augmented molecular dynamics simulations to study RNA-ligand interactions, validating predictions of mutations affecting binding affinities in riboswitch systems.

The paper analyzes small RNA expression dynamics in tomato accessions to show how genomic structural variants influence different small RNA classes and their selection pressures during domestication.

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The paper sequences and annotates three Pseudomonas strains, finding that AFB1-degrading strains have more genes related to xenobiotic metabolism and oxidoreductase activity.

The paper describes eight novel bacterial species isolated from cynomolgus monkey feces and provides their taxonomic characterization.

This study shows that nutrient metabolism and ER redox homeostasis regulate insulin granule formation in pancreatic β-cells, linking glucose metabolism to proinsulin export and T2D pathogenesis.

This paper engineers neuron-targeting extracellular vesicles for in utero treatment of myelomeningocele, showing improved neuroprotection and reduced apoptosis in a rodent model.

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

This study shows that mitochondrial UPR suppresses wounding-induced innate immunity in C. elegans epidermis by inhibiting ATFS-1 and modulating downstream signaling pathways.

The paper links diet-derived metabolites and mucus to fever after cytotoxic cancer treatment by showing how Akkermansia muciniphila affects colonic mucus and inflammation.