Y. Wang

This study shows that loss of SHMT2 promotes 5-FU resistance in CRC by inducing autophagy through p53 regulation.

This study shows APOC2 promotes colorectal cancer by altering lipid metabolism and activating PHF8 transcription, linking it to poor prognosis.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

This study investigates Paramecium's extreme tolerance to γ rays, finding its LD50 is 3000 Gy, 60 times higher than humans, and identifies two upregulated genes potentially involved in DNA protection.

This study measures left ventricular geometry and ESPVR during vena cava occlusion in sheep using real-time MRI and a modified segmentation method, revealing non-linear responses and chamber collapse.

This study identifies multiple noncanonical PAMs recognized by SpCas9 in human cells, improving understanding of off-target mutation risks.

The paper shows that UT-A1/A3 knockout mice have increased urinary ATP and purinergic signaling, linked to AVP-resistant polyuria.

This study investigates how HER2 dynamics in filopodia regulate protrusion growth and signaling in breast cancer cells, revealing distinct motion patterns and functional roles in protrusion-based signaling.

The paper evaluates how non-canonical guide RNAs and Cas9 variants affect DNA unwinding, finding that some combinations reduce off-target activity while maintaining on-target efficiency.

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.

This paper develops rice tissue media to enhance conidiation of Ustilaginoidea virens, improving pathogenicity testing and genetic analysis for false smut resistance.

This study develops PSMA-targeted nanobubbles for real-time ultrasound imaging of prostate cancer in mice, showing improved tumor detection and retention.

DrugComb provides an open-access portal for drug combination screening data, enabling analysis and prediction of drug synergy using linear regression and chemical fingerprints.

This study shows grass carp do not regenerate cardiac tissue after cryoinjury, instead developing persistent fibrosis and reduced cardiac function.

This study identifies subtype-specific influenza A virus-host protein interactions that correlate with different pathogenic outcomes.

The paper identifies an immune signature in invasive ductal carcinoma that predicts prognosis and response to immunotherapy.

This study identifies TRIM21-SERPINB5 as a mechanism promoting radioresistance in nasopharyngeal carcinoma by repressing TP53 through GMPS degradation.

This study uses OCTA to analyze collaterals and vessel density in RVO, finding associations between collateral types and reduced vessel density in specific retinal layers.

The paper uses agent-based simulations to study how environmental factors shape the evolution of quorum-sensing strategies in bacteria, revealing how genetic constraints influence cooperation and resilience against cheaters.

The paper introduces a modified ABE method that reduces background noise in S-acylproteomic analysis, enabling the identification of 2,895 high-confidence S-acylated proteins in human prostate cancer cells.

This study identifies ANP32A and ANP32B as essential host factors that facilitate HIV-1 unspliced RNA export via the Rev-CRM1 pathway.

This paper integrates gene network, metabolic, and leaf-level models to predict genetic modifications that could enhance soybean photosynthesis under elevated CO2 levels.

The intestinal microbiota induces daily metabolic rhythms and controls lipid uptake through the enzyme histone deacetylase 3.

This study investigates the dynamic metabolic changes in Ulva prolifera during fragmentation-induced proliferation, identifying key metabolites involved in reproduction and stress response.

This paper develops a superresolution traction force microscopy method to measure subcellular forces in immune cell-target interactions without using embedded tracers.

This study shows that epithelial RARβ regulates vitamin A-dependent intestinal immunity by promoting SAA expression and Th17 cell IL-17 production.

This study estimates the divergence time of anaerobic rumen fungi and identifies laterally acquired genes that contribute to their plant biomass degradation capabilities.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.