Y. Wang

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

The paper demonstrates efficient combined nitrogen, phosphorus, and chemical oxygen demand removal in a wastewater treatment system using anaerobic-aerobic cycling and nitritation-denitritation without exogenous chemicals.

This paper introduces a hybrid Benders algorithm for strain design using a network interdiction model, achieving efficient and scalable solutions for metabolic network redesign.

This study identifies NIMA family kinases as regulators of clathrin-mediated endocytosis in C. elegans, showing their interaction with AP2 and functional conservation in humans.

This study analyzes the vagino-cervical microbiome of 516 women using metagenomic shotgun sequencing to explore how pregnancy, delivery, and contraception influence microbiome composition.

This study evaluates the efficacy of secretory IgA2 and dimeric IgA2 antibodies against ETEC in a non-human primate model, finding that oral SIgA2 significantly reduced diarrheal attack rates.

This paper introduces NIPSS, a nanopore sequencing method for direct miRNA sequencing, demonstrating single-molecule resolution and potential applications in cancer diagnostics and therapeutics.

The paper introduces PSX, a software tool for calculating deuterium-exchange effects in SANS measurements from protein coordinates, showing that the common 90% exchange assumption is often an overestimate.

The paper identifies B3GALT4's dual role in GPI and glycosphingolipid biosynthesis and shows ER-associated degradation suppresses GPI biosynthesis when GPI transfer to proteins is defective.

This study identifies the genetic basis for the evolution of a novel floral scent in wild tobacco, showing how gene expression changes lead to adaptive volatile compound production.

This study examines how shift-work affects carotid artery health and cerebral blood flow in SHR and WKY rats, finding increased blood pressure, arterial thickening, and reduced blood flow.

This paper introduces obSTORM, a method for super-resolution imaging of thick samples, achieving isotropic resolution over significant depths.

The paper assesses CRC screening and follow-up colonoscopy rates in a Chinese urban district, finding low participation and follow-up rates despite high CRC prevalence.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

This paper introduces a method to achieve high-precision 3D nanoscopy across whole cells and tissues by retrieving the in situ point spread function from single-molecule data.

This study shows that engineering CAR-T cells with CD103 improves their anti-tumor efficacy against E-cadherin positive tumors by enhancing infiltration, expansion, and persistence in vivo.

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

This study shows non-antibiotic pharmaceuticals can increase antibiotic resistance spread via conjugation by enhancing ROS production and cell membrane permeability.

The paper investigates how the 4F peptide interacts with β-amyloid to form toxic heteromers, reducing aggregation kinetics and increasing neurotoxicity.

This study shows that miR-15a mimic, especially modified with 5-FU, reduces PDAC cell proliferation and tumor growth, suggesting its therapeutic potential and prognostic value.

The paper samples Hawaiian C. elegans strains, revealing high genetic diversity and admixture with global populations, suggesting ancestral diversity preserved in Hawaii.

This study examines evolutionary changes in the phosphoenolpyruvate transporter (PPT) during C4 photosynthesis emergence, identifying shifts in expression, light responsiveness, and cis-element acquisition in PPT1.

This study identifies distinct genetic mutations in well-differentiated papillary mesothelioma (WDPM) that differentiate it from malignant mesothelioma.

The paper shows that Psd2-dependent phosphatidylethanomaine production in yeast relies on Psd2, Sfh4, and Stt4, with Sfh4 activating the pathway through a physical interaction rather than its PtdIns transfer activity.

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

The paper introduces a deep learning model to predict the metastatic origin of secondary liver cancer from H&E stained tissue sections, achieving 90.2% accuracy comparable to expert pathologists.

This study identifies ANP32A and ANP32B as essential for influenza A virus polymerase activity, showing species-specific roles and mutations affecting viral replication.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

The paper shows that the intrinsic heart rate has a circadian rhythm driven by a local clock in the sinus node, regulating Hcn4 expression and funny current.