Y. Yu

This study identifies STK11IP as a lysosome-specific mTORC1 substrate that regulates lysosomal acidification and autophagy, with implications for therapeutic targeting of autophagy-related diseases.

This meta-analysis evaluates the effect of 0.01% atropine on axial elongation in myopic children using orthokeratology, finding it significantly reduces axial elongation.

This study identifies a novel MarR subfamily, MarRars, that regulates arsenic resistance genes by responding to As(III) and Sb(III) and repressing arsV expression.

The paper predicts conserved T-cell epitopes in SARS-CoV-2 variants using computational methods to identify antigenic peptides that could be used in vaccines.

This study uses Drosophila larval models to investigate tumour/host tissue interactions in cancer cachexia, showing that specific genetic factors drive tissue wasting rather than general tumour burden or malnutrition.

The paper examines allele frequency changes at eQTLs in Drosophila melanogaster across latitudinal clines and seasons, finding clinal eQTLs are more predictable than seasonal ones.

This study shows that phage resistance mechanisms in A. baumannii reduce colistin resistance by altering bacterial envelope structure, increasing antibiotic sensitivity.

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

This paper sequences and annotates the Streptochaeta angustifolia genome, revealing insights into grass evolution, gene duplication, and small RNA regulation.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

This study identifies Spx-dependent and Spx-independent mechanisms that suppress division defects in a Bacillus subtilis minD noc double mutant at high temperature.

This study shows that circadian rhythms control heparan sulfate levels, which regulate phagocytosis of amyloid-beta aggregates in a mouse model of Alzheimer's disease.

The paper investigates how AKR1C and NADH contribute to cis-platin resistance in HepG2 cells using transcriptomic and metabolic analysis.

This study identifies oxygen depletion and nitric oxide as stimuli that trigger MSHA pilus retraction in V. cholerae via the phosphodiesterase CdpA.

This study shows that combining AKT and KIT inhibitors restores PDCD4 expression in GIST cells, leading to cell death, but the combination is less effective in IM-resistant models.

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

The paper shows that phagosome cargo degradation is kinetically coupled to their intracellular motility, not stochastic.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

This study shows that knocking down PxRdl2 with dsRNA enhances the insecticidal effects of GABAR-targeting compounds against Plutella xylostella.

This study identifies TFAM3 as a regulator of shoot meristem maturation in plants, showing that ALOG family proteins form transcriptional condensates to control flowering timing and inflorescence architecture.

This study identifies familial thyroid follicular cell carcinomas in Dutch German longhaired pointers, finding a high heritability and inbreeding contribution to the disease.

The paper identifies sulphate-TOR signalling as a key pathway for transcriptional reprogramming during shoot apex activation in Arabidopsis, revealing its role in growth and stress responses.

This study shows that SARS-CoV-2 N protein modulates innate immunity by both suppressing and promoting IFN-I and inflammatory responses depending on its dosage.

This study presents cryo-EM structures of human p97 complex with and without inhibitor NMS-873, revealing conformational changes and allosteric inhibition mechanisms.

This study shows that increasing semi-natural habitats in conventional cruciferous vegetable fields improves pest suppression by natural enemies, with effects varying by pest type and landscape scale.