Y. Yu

The paper investigates how the timing of phagosome transport from actin to microtubules affects the kinetics of early phagosome maturation and its transition to late phagosomes.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This paper develops an optical brain-computer interface using hippocampal calcium activity in mice to decode spatial, visual, and auditory information in real time with high accuracy.

The paper uses super-resolution imaging to show how Dectin-1 and TLR2 nanoclusters interact synergistically to enhance signaling in macrophages.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

The paper identifies persistent immune and clotting dysfunction in saliva and plasma of COVID-19 patients 4-6 weeks post-symptom resolution, highlighting saliva as a viable alternative to plasma for monitoring immune and inflammatory sequelae.

The paper shows lamin A/C enables nuclear deformation through fibrous environments by acting like surface tension, allowing nuclei to bypass obstacles without rupturing.

This study shows that Schwann cells activated by cancer cells form tracks that promote pancreatic cancer invasion through c-Jun-dependent mechanisms.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

This study shows that DDX60 selectively inhibits translation from type II viral IRESs, reducing replication of EMCV and FMDV but not type I IRES viruses.

PPRD integrates and curates ~45,000 plant RNA-seq libraries into a searchable database to facilitate expression analysis.

This study shows that interrupting central tolerance generates high-affinity T cells that avoid exhaustion and enhance cancer immunotherapy.

This study characterizes GR13 plasmids in Acinetobacter, showing their capacity to accumulate and horizontally transfer diverse accessory genes through dif modules and insertion sequences.

The paper determines the high-resolution structure of MgtE TM domain with Ca2+ and shows Mg2+ binds 500-fold stronger than Ca2+.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.

This study uses cryo-electron tomography to reveal the high-resolution 3D structure of human red blood cell membranes and their protein distribution.

This study identifies ORF8 as a secreted glycoprotein that drives severe COVID-19 through NLRP3 inflammasome activation and shows it is inhibited by MCC950.

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

Mutations in the auxin importer gene Spp1/SvAUX1 reveal broad developmental effects in shoots, inflorescences, and flowers, with non-redundant roles among AUX1 homologs.

This study examines beetle evolution through the end-Permian mass extinction, showing xylophagous beetles declined due to forest collapse and later rebounded with forest recovery.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

This study shows that Zika virus infection of monocytes triggers both apoptosis and pyroptosis, with pyroptosis being NLRP3-dependent and caspase-1-mediated.

This paper shows that proline hydroxylation and histidine methylation on actin regulate cell motility through a crosstalk mechanism involving PHDs, VHL, and SETD3.

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.