Y. Zhao

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

The paper examines the genomic bases of ecological diversification in core landbirds, identifying adaptive enhancements in diet and vision related to their lifestyles.

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

This paper demonstrates a laser-induced cell sorting technique that isolates and cultivates single microbial cells with viability, achieving varying recovery rates across different species.

This study presents two cryo-EM structures of human KCC1, revealing its inward-open and outward-open states and the mechanism of inhibition by a small molecule.

The paper identifies five ABCB transporters that regulate lateral root spacing in Arabidopsis by modulating auxin oscillation amplitude in outer root tissues.

The paper examines ACE2 expression on immune cells and finds that activated type 1 macrophages (M1) have high ACE2 expression, suggesting they may be targeted by SARS-CoV-2.

This study investigates the effect of hydrogen inhalation on SIgA, PIgR, and cytokines in a COPD rat model, finding improved expression of SIgA and related factors with higher hydrogen concentrations.

The paper tests the Red Queen hypothesis by analyzing two Drosophila de novo miRNAs, finding their fitness contributions vary between species, supporting their different evolutionary fates.

This paper identifies an antibody, EY6A, from a convalescent patient that neutralizes SARS-CoV-2 and cross-reacts with SARS-CoV-1 by binding a conserved epitope on the Spike protein.

The paper identifies temporal dynamics of QTL effects on vegetative growth in Arabidopsis thaliana using genome-wide association analysis across timepoints.

The paper develops two methods to construct high-content nanobody libraries in mammalian cells using linear-double-stranded DNA strategies, generating over a million unique sequences.

This paper identifies and profiles bisecting N-acetylglucosamine modifications in human amniotic membrane through glycomic and glycoproteomic analyses, revealing 41 glycoproteins with this modification.

The paper investigates the relationship between cell cycle phases and migratory behaviors in NIH 3T3 fibroblasts, showing synergies between cell cycle regulators and migration.

The paper identifies DNase activity in invadosomes across cell types and species, revealing DNase X as the recruited enzyme that degrades extracellular DNA.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

animalcules provides an interactive R toolkit for analyzing 16S rRNA, shotgun metagenomics, and metatranscriptomics data with visualization and machine learning tools.

This paper introduces ScatNet, a deep-learning method for restoring 3D fluorescence microscopy images of turbid biological specimens, improving resolution and signal-to-noise ratio.

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

This study investigates how different stiffness levels of injectable biomaterials affect ventricular mechanics and myocardial infarct reinforcement in vivo.

This paper demonstrates a tunable ultrafast stroboscopic TEM system that reduces radiation damage in macromolecules by increasing critical dose at room temperature.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This paper develops a physics-based model to study conformational ensembles of intrinsically disordered proteins, showing how interactions and sequence specificity affect their dynamics.

This study identifies and characterizes ZmCPAs in maize, showing their roles in salt tolerance through expression analysis and functional validation.

This study shows Carmofur inhibits SARS-CoV-2 main protease by covalently binding to Cys145 and occupying the S2 subsite, with an EC50 of 24.30 M in cell-based viral replication assays.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study identifies HuR as a kinetically-privileged sensor of the electrophile HNE, showing its role in regulating Nrf2-driven antioxidant responses through cysteine C13.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.