Y. Zhao

This study designs, synthesizes, and evaluates two peptidomimetic aldehydes as antiviral drug candidates targeting SARS-CoV-2 main protease, showing potent inhibition and anti-infection activity.

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

This paper develops a transferable and interpretable deep learning model for MSI prediction from histopathology images, achieving high AUC scores in two cohorts.

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

This study evaluates CHIPS as a therapeutic agent for inflammation, showing promise in mice but safety concerns in humans due to pre-existing antibodies.

The paper identifies how TGF-β signaling inhibition allows GATA4 to interact with JMJD3, promoting cardiomyogenesis by demethylating H3K27me3 at cardiac gene promoters.

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

The paper develops a tandem tension sensor to measure integrin molecular tensions in live cells and finds that these tensions decrease with increasing substrate rigidity.

This study investigates how ammonium accumulation from nitrogen and carbon metabolism imbalance inhibits growth in Methylomonas sp. ZR1 and identifies strategies to mitigate this inhibition.

The paper constructs a nanobody library in mammalian cells using an ldsDNA-based AND gate genetic circuit, generating 22,173 unique sequences.

This study develops a method to mature hiPSC-CMs, enabling them to model adult-onset cardiovascular disease like hypertrophic cardiomyopathy.

The paper reports the complete genome sequence of a novel BPV type 15 strain from a cow in southern Xinjiang and places it phylogenetically within the Xipapillomavirus genus.

This study isolates and characterizes ten novel pelagiphages infecting Pelagibacter strains, revealing their genetic diversity, global distribution, and ecological significance.

This study identifies six new Neodon species using systematic sampling and low coverage whole genome sequencing, revealing the Qinghai-Tibetan Plateau as the origin and highlighting climate change and geographic isolation as drivers of speciation.

This study shows that RdRp speed and fidelity are not the only factors determining recombination efficiency in poliovirus, highlighting additional biochemical properties involved.

This study identifies Notopterol as a JAK2/3 inhibitor that reduces inflammation and arthritis by blocking macrophage cytokine production in animal models.

This study reveals that clofarabine inhibits DNA synthesis by targeting ZRANB3, a newly identified DNA-synthesis promoter, and shows its role in tumor invasion and transformation.

This study demonstrates a mechanism for periodic pattern formation in multi-species bacterial colonies through reciprocal density-dependent motility activation.

This study examines changes in IL-10 expression in myocardial infarction and its association with macrophage activation and cardiomyocyte apoptosis over time.

The paper uses QTL mapping to show MHC variants bias TRBV gene usage in UCB samples, revealing germline-encoded TCR-MHC contacts influence TCR repertoire.

This study identifies widespread arginine phosphorylation in human cells using a novel phosphoproteomic workflow, revealing 152 high-confidence sites across 118 proteins.

This study identifies G-CSF as a metabolic niche factor that replenishes Pax7Hi muscle stem cells in aged mice through exercise-induced mechanisms.

The paper isolates and characterizes seven phages infecting Roseobacter RCA lineage bacteria, revealing genomic diversity and abundance in marine virosphere.

The paper identifies and characterizes phages infecting Fonsibacter, showing their global distribution and ecological impact on freshwater microbial communities.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

The paper identifies an immune signature in invasive ductal carcinoma that predicts prognosis and response to immunotherapy.

This study shows that the nurf-1 gene in C. elegans split into two isoforms, Yin and Yang, which have opposing roles in gametogenesis and led to the creation of two separate genes.

The paper identifies a molecular crosstalk where PD-L1 and CD80 form a heterodimer, blocking inhibitory pathways but preserving CD28 activation, and shows how PD-L1 blockade affects CD80 expression.

This study shows ionomycin treatment rescues osteoporosis in HPP by restoring Ca2+ influx via ALPL-mediated L-type Ca2+ channel trafficking in BMSCs.