Z. Chen

This study shows that CRTC-CREB activation drives LKB1-null lung cancer growth and identifies it as a therapeutic target.

This study examines co-infection and secondary infection rates in COVID-19 patients, finding low rates of Streptococcus pneumoniae co-infections and common secondary pathogens like S. maltophilia.

This paper develops an algorithm for non-contact respiration rate measurement using UWB radar and validates its accuracy against ground truth data.

This paper introduces DEAS, a simulator that predicts crop latitude adaptation using florigen gene expression, enabling faster breeding for climate-resilient crops.

AlphaTracker is a computer vision tool for multi-animal tracking and behavioral analysis, designed for ease of use and real-time performance in studying social interactions in mice.

This study identifies PCSK9 as a target to enhance CD8+ T cell antitumor activity by modulating LDLR and TCR signaling in the tumor microenvironment.

BiTSC2 jointly analyzes single-cell SNV and CNA data to infer tumor clonal trees with high accuracy and robustness to low sequencing depth.

This study identifies LsAP2 as a transcription factor regulating seed shape in lettuce, showing its role in seed development and dispersal through interactions with LsBP and involvement in brassinosteroid pathways.

This study uses pH-sensitive fluorescent protein to track vacuolar pH changes during cell-in-cell mediated death, revealing distinct pH dynamics in entotic and apoptotic death and their implications for cancer treatment.

The paper investigates the mechanical anisotropy of ZIKV xrRNA1 using single-molecule nanopore sensing and molecular dynamics simulations, revealing its dependence on Mg2+ and tertiary interactions.

This paper introduces a fast 3D printing method called FLOAT to create large-scale biocompatible hydrogel models with minimal deformation and cellular injury.

This study shows HuR promotes NASH by enhancing DR5/caspase8/caspase3-mediated hepatocyte death through stabilizing DR5 mRNA.

This study identifies and characterizes 57 B3 superfamily genes in pineapple, revealing their chromosomal distribution, evolutionary relationships, and expression patterns during flower induction.

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

This study shows DRP1 is essential for early adipogenesis but not later stages in brown and beige adipocytes.

This study shows miR-224 promotes HCC cell migration and invasion by targeting HOXA5 and ADAM17, suggesting it as a potential therapeutic target.

The paper uses single-molecule techniques to show catalysis does not enhance diffusion of alkaline phosphatase, contradicting previous FCS results attributed to substrate-induced dye blinking.

This paper introduces pnGFP-Ultra, a fluorescent biosensor for detecting peroxynitrite in live cells with high selectivity and sensitivity.

The paper shows that the interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat by maintaining brown adipocyte identity and thermogenic function.

This study performs a time-course transcriptome analysis of lettuce achenes to identify gene expression patterns and molecular mechanisms during achene development.

This study evaluates the efficacy and safety of combining ipratropium bromide and salbutamol in children and adolescents with asthma, finding reduced hospital admissions but no significant adverse event differences.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

The paper isolates and characterizes 61 SARS-CoV-2-neutralizing monoclonal antibodies from infected patients, identifying potent antibodies targeting multiple epitopes on the spike protein.

This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.

This study presents the first crystal structure of the Vip3A toxin, revealing its domain organization and glycan binding specificity, which informs its insecticidal mechanism and potential for improved bio-insecticides.

This study shows that Swi6 condensation provides mechanical stiffness to the nucleus, demonstrating a mechanical function of biomolecular condensates.

The paper identifies the role of clathrin's N-terminal domain in CME and develops a peptide inhibitor that specifically blocks CME without affecting other endocytic processes.

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.