Z. Liu

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

This study develops a serum-based immunotherapy strategy using antibodies from mice exposed to cutaneous squamous cell carcinoma, showing reduced tumor volume and reversal of key protein markers.

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

The paper identifies replication stress as a driver of BRCA1-deficient breast tumorigenesis in luminal progenitors, showing ELF3 upregulation promotes this process.

This paper develops a self-assembling ferritin nanoparticle vaccine targeting DBV Gn head region that fully protects aged ferrets from lethal DBV challenge.

The paper shows that M2 macrophages prevent preterm birth and improve neonatal outcomes by reducing in utero sterile inflammation in mice.

This study shows MYCN drives oncogenesis by cooperating with WDR5 to activate MYC targets and G9a to repress differentiation genes, and targeting both synergistically inhibits neuroblastoma growth.

The paper identifies a compound that degrades both SALL4 isoforms, overcoming IMiD limitations in liver cancer treatment.

The paper develops DICTrank, a comprehensive list of 1318 human drugs ranked by cardiotoxicity risk using FDA labeling, identifying therapeutic categories with high DICT potential.

This paper introduces a nanobead-based single-cell single-molecule pulldown (sc-SiMPull) method that is faster, easier, and more versatile than existing techniques for studying protein-protein interactions in single cells.

This study shows that AAV-Tnnt2 vectors leak into the liver, reducing cardiac specificity, and demonstrates that adding miR122 target sequences reduces this leakiness.

This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.

This study shows that SENP1 deficiency in cardiomyocytes promotes myocardial fibrosis and cardiac dysfunction after MI through paracrine effects, by regulating HSP90ab1 SUMOylation and STAT3 signaling.

The paper develops CHAMP, a method to measure cytosolic accumulation of azide-tagged molecules in Gram-negative bacteria, enabling high-throughput screening of over 1,000 compounds.

This study identifies Zfp697 as a regulator of muscle regeneration and inflammation by mediating interferon gamma signaling and interacting with ncRNAs like miR-206.

This study shows that endothelial cell quiescence under flow is temporally regulated and depends on p27, with arterial flow leading to deeper quiescence requiring HES1 and ID3.

This study identifies persistent urine metabolome alterations in T. cruzi-infected mice that are not reversed by antiparasitic treatment, suggesting urine as a potential diagnostic tool for Chagas Disease.

This study shows that BRN2 controls XGA synthesis, which facilitates RCPG export and BLC separation in Arabidopsis.

The paper investigates ORC and MCM dynamics at chromatinized origins in yeast, finding that chromatin reduces MCM mobility while maintaining ORC binding efficiency.

This study compares the growth and transcriptomic responses of two Vibrio parahaemolyticus strains with different virulence genes at varying temperatures, showing differential growth rates and gene expression patterns.

This study determines the structure of PlsB from Themomonas haemolytica using cryo-EM, revealing three domains and their roles in membrane association, catalysis, and dimerization.

The paper discovers a new RNA-to-polypeptide pathway involving msRNAs, msdRs, and msdPs, with potential cancer-related applications.

This study develops an mRNA vaccine encoding four vaccinia antigens that induces strong immune responses against vaccinia and monkeypox viruses, suggesting broad orthopoxvirus protection.

This study shows Ebola virus uses viral inclusion bodies to sequester IRF3, blocking type I interferon production and evading antiviral immunity.

This study establishes and evaluates rat models of cervical spondylopathy with Yin deficiency syndrome through sleep deprivation and behavioral assessments.

This study identifies the recycling endosome biogenesis machinery as critical for BACE1 endosomal sorting and amyloid-beta production in Alzheimer's disease.

This study shows that SARS-CoV-2 boosting induces GC B cell responses and that Omicron-based vaccines can elicit novel epitope-specific antibodies despite antigenic imprinting.

This study compares lysine-based and site-specific protein immobilization methods in single-molecule force spectroscopy, finding that lysine-based methods degrade signal quality and alter unfolding pathway classification.

This study evaluates phage clearance and host responses to repeated intravenous phage doses in rats and monkeys, finding faster clearance and immune activation with repeated administration.