Z. Zhang

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

This study presents the cryoEM structure of LCMV surface glycoprotein and shows that the antibody M28 neutralizes the virus by stabilizing its prefusion state, offering a therapeutic candidate for LCMV infection.

This study shows obesity disrupts pituitary UPR, leading to NAFLD, and demonstrates that restoring pituitary UPR can ameliorate metabolic defects.

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

The paper develops a rapid non-destructive method to phenotype stomatal traits using imaging and machine learning, achieving high accuracy and efficiency.

This paper evaluates three spike detection algorithms and two thresholding methods for BMIs, comparing their hardware efficiency and performance on FPGA.

This study links gut microbial depletion of Lachnospiraceae genera to lower HDL-C and hypertension in a high-calorie diet population, suggesting HDL-C as a mediator.

The paper develops MILL, a technique to rapidly create 3D micro-patterned flow channels that mimic in vivo fluid shear stress environments, enabling real-time study of cell adhesion and translocation.

The paper identifies lineage-specific genes (LSGs) in Neurospora crassa that cluster with allorecognition loci and respond to environmental factors regulating the switch from asexual to sexual reproduction.

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

The paper identifies a high-confidence plasmodesmata proteome in Physcomitrium patens using iterative scoring and validation, revealing evolutionary diversification of cell wall proteins.

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

This paper develops a high-throughput single-cell imaging technique to quantify fractal properties of cell morphology, enabling classification of lung-cancer subtypes and tracking of cell-cycle progression.

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

This paper integrates multi-omic data to characterize chemical bioactivity at transcriptomic, proteomic, and phosphoproteomic levels, showing how early phosphoproteomic changes drive downstream effects.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

The paper investigates how the timing of phagosome transport from actin to microtubules affects the kinetics of early phagosome maturation and its transition to late phagosomes.

The paper reports the in situ structure of SARS-CoV-2 Delta variant virions and captures membrane fusion snapshots, revealing unique architectural features and fusion mechanisms.

This study shows that CTRP3 reduces intestinal inflammation in colitis models and IBD patients by modulating SIRT1/NF-κB signaling to suppress pro-inflammatory cytokines.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study identifies DNALI1 as a key protein in sperm development, showing its role in the MEIG1/PACRG complex for cargo transport along the manchette and its involvement in sperm individualization.

This paper introduces a chemical derivatization method using N-Me aziridination to precisely identify C=C bond positions in lipids via mass spectrometry.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

The paper develops a pipeline to analyze grain quality traits in hybrid rice by identifying additive and dominant genetic loci, improving prediction accuracy for hybrid performance.

This study uses culture-enriched phenotypic metagenomics to monitor clinically-important beta-lactam resistance genes in a wastewater treatment plant and river.

This paper develops hardware-efficient compression for neural multi-unit activity signals, reducing bandwidth and power usage while maintaining decoding performance.