Z. Zhang

This study evaluates pretraining strategies in an interpretable multimodal deep learning framework for cancer prognosis, showing that pretraining improves performance over standard methods.

This study shows that actin dynamics at photoreceptor cilia tips regulate disc formation, and RPGR mutations disrupt this process, leading to retinal degeneration.

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

The study analyzes language gene polymorphism patterns across populations to infer human evolutionary history and finds that ancient samples from Nepal contain all four distinct LGPPs.

This paper introduces wMSDc, a classifier to distinguish directed and diffusive transport in short, noisy single-molecule trajectories, showing superior performance compared to existing methods.

The paper uses RS-mimic peptides to study phase separation of SRSF1, revealing that combined stacking and electrostatic interactions drive this process.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This study characterizes the microbial and peptidomic composition of raw and heated milk kefir and shows that raw milk kefir suppresses allergic responses in mice.

This study identifies intronless ERF transcription factors as a molecular tool used in the evolution of C4 photosynthesis in multiple plant lineages.

This paper describes a system for generating and assessing e-cigarette aerosol exposure in animals, showing higher nicotine concentrations in arterial blood compared to venous blood.

The paper introduces digital nanoreactors to control and study the stoichiometry, spatial arrangement, and temporal dynamics of membrane protein interactions.

This study shows that enhancing STAT5a activation in exhausted CD8 T cells rewires their epigenetic state to become a hybrid durable effector-like population with improved tumor control.

This study shows that MLL3/TP53/PIK3CA mutations in breast tumors promote immunosuppressive Treg cell differentiation via HIF1alpha, leading to tumor growth and suggesting therapeutic targets.

The paper describes the BlueFlux field campaign, which measures CO2 and CH4 fluxes in mangroves using multiple methods and scales them to gridded products to improve climate change mitigation strategies.

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

This study shows retrotransposons use the alt-EJ DNA repair pathway to generate eccDNA and achieve mobilization.

This study reveals how GTP cycling gates CTP synthase activation through three sequential checkpoints, linking GTP binding and dissociation to catalytic steps in CTP synthesis.

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

This study determines the structure of TPH2's regulatory domain with L-Phe and shows it is a better ligand than L-Trp, revealing dynamic behavior in the tetramer.

This study shows that Pex13 and Pex5 undergo liquid-liquid phase separation to form transient transport channels for cargo into peroxisomes.

The paper shows MATR3 and antisense LINE1 RNAs form a meshwork that organizes chromatin, and their disruption causes chromatin reorganization.

This study determines the cryo-EM structure of SLC19A1 and identifies key residues and coupled substrates for folate recognition.

The paper introduces contact stiffness as a framework to quantify how ECM mechanics influence cell behaviors, showing its correlation with YAP activity and stem cell differentiation.

This study shows that initial niche conditions determine the aging speed and regenerative activity of quiescent fission yeast cells, with regenerative activity declining linearly before survivability.

This paper demonstrates that nerve systems can exhibit bistable conduction, where stimulus-dependent fast and slow conduction waves occur due to sodium channel inactivation and calcium current interactions.

This paper introduces a method to locate cellular contents during cryoFIB milling using secondary-electron imaging, demonstrating its feasibility across different instruments and conditions.

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study identifies Sanofi-14h, an AGC kinase inhibitor, as a regulator of STING signaling that acts through both SGK-dependent and SGK-independent mechanisms to suppress IFNβ expression.