John M. Starr

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

The paper identifies novel genetic loci associated with blood pressure that interact with sleep duration across multiple ancestries.

Plasma lipid and liporotein biomarkers in LBC1936: Do they predict general cognitive ability and brain structure?

This study identifies lipid biomarkers associated with brain structure but not cognitive ability in older adults using metabolomic data from the LBC1936 cohort.

SNPs associated with HHIP expression have differential effects on lung function in males and females

The paper identifies SNPs with sex-specific effects on lung function traits using UK Biobank data, finding a significant interaction at rs7697189 near HHIP.

Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

The paper quantifies microstructural changes in normal-appearing white matter near white matter hyperintensities in older adults, showing spatial gradients of damage linked to WMH burden.

Neurology-related protein biomarkers are associated with general fluid cognitive ability and brain volume in older age

This study identifies neurology-related proteins in plasma associated with cognitive ability and brain volume in older adults, with partial mediation by brain volume.

Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

The paper examines associations between retinal vascular parameters and cerebral small vessel disease in two cohorts, finding that arteriolar fractal dimension relates to white matter hyperintensities.

Polygenic predictors of age-related decline in cognitive ability

This study uses polygenic scores to predict cognitive ability at age 70 and cognitive change from 70 to 79, finding limited predictive validity compared to APOE e4.

Brain peak width of skeletonised mean diffusivity (PSMD), processing speed, and other cognitive domains

The paper examines the association between brain peak width of skeletonised mean diffusivity (PSMD) and cognitive domains, finding it correlates with processing speed but not more strongly than other brain imaging measures or cognitive domains.

GWAS meta-analysis (N=279,930) identifies new genes and functional links to intelligence

This study identifies 206 new genomic loci and 1,041 genes associated with intelligence using a large GWAS meta-analysis of 279,930 individuals.

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Large-Scale cognitive GWAS Meta-analysis Reveals Tissue-Specific Neural Expression and Potential Nootopic Drug Targets

This study performs a large-scale GWAS of cognitive ability, identifies 70 genomic loci, and finds tissue-specific gene expression and potential drug targets.

Brain Structural Differences Between 73- And 92-Year Olds Matched For Childhood Intelligence, Social Background, And Intracranial Volume

The paper matches 73- and 92-year-olds for childhood intelligence, social background, and brain size, finding significant structural brain differences linked to cognitive decline.

Do Candidate Genes Affect the Brain’s White Matter Microstructure? Large-Scale Evaluation of 6,165 Diffusion MRI Scans

The paper evaluates 15 candidate SNPs associated with psychiatric disorders using 6,165 diffusion MRI scans, finding no significant associations after correction for multiple testing.