Adriano Aguzzi

This study develops an ex vivo mouse brain slice model that mimics brain aging and shows prions accelerate aging-related molecular changes.

The paper constructs genome-wide CRISPR libraries for gene ablation, activation, and silencing with high efficacy and reports novel gene regulators and modifiers.

The paper shows that dendritic responses in L5 pyramidal neurons during learning correspond to unsigned temporal difference error components, with salience signals aiding task learning.

The paper develops a human iPSC-derived neural model to study TDP-43 pathology, identifying NPTX2 misregulation as a key factor in ALS/FTLD neurotoxicity.

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.

The paper shows that loss of PIKfyve contributes to spongiform degeneration in prion diseases by linking prion infection to PIKfyve destabilization and vacuolation.

The paper identifies 38 genes regulating a-synuclein cell-to-cell transfer using an siRNA screen and shows genetic overlap with Parkinson's disease.

This paper shows that ASC controls AA amyloidosis by interacting with SAA and that anti-ASC antibodies reduce amyloid loads in mice.

This study shows LAG3 is not expressed in human and mouse neurons and does not worsen α-synuclein pathology in vitro or in vivo.

This study investigates the role of Msr1 in prion clearance and pathogenesis, finding that Msr1 deficiency does not affect prion disease progression or neuroinflammation.

This study shows that pericytes restrict immune cell entry into the CNS by maintaining immune quiescence of brain endothelial cells, and their deficiency leads to increased leukocyte infiltration and severe neuroinflammation.

This study investigates the role of PrPC in hippocampal function using PrnpZH3/ZH3 mice, finding behavioral deficits, learning impairment, and increased excitability without enhanced LTP.

This paper identifies 54 novel regulators of PrPC expression through a genome-wide RNA interference screen, with 9 confirmed by CRISPR interference, revealing potential therapeutic targets for prion diseases.

This study shows that the prion protein is not required for sciatic nerve regeneration after crush injury in mice.

This study uses longitudinal whole-brain imaging to show that anti-Aβ therapies have distinct spatial and temporal efficacies, with polythiophenes showing strong Aβ clearance.

The paper shows that glial activation in prion diseases is nonautonomous, requiring neuronal PrPSc to drive neural dysfunction.

This study tests a dimeric prion protein ligand as a therapy for peripheral demyelination but finds it fails to rescue myelinopathy in PrP-deficient mice.

The paper identifies a developmental transition in VIP+ and SST+ interneurons in the mouse barrel cortex around P14, where their responses to multi-whisker stimuli diverge and their thalamic inputs shift.

This study uses ribosome profiling to show that prion disease causes minor translational changes in neurons but significant changes in glia, overlapping with other neurodegenerative diseases.

The paper identifies protective anti-prion antibodies in human immunoglobulin repertoires and finds they are present in healthy individuals without associated pathologies.

The paper describes a human cell line, hovS, that can be infected with sheep-derived prions and exhibits prion-related cytopathology, offering a safer alternative to human prion studies.

The paper identifies early molecular changes in prion-infected mice, suggesting glial pathophysiology as a key driver and potential targets for intervention.

This study shows that the cellular prion protein facilitates tau amyloid uptake and reduces prion propagation in cultured cells.

The paper introduces vMSOT with AOI987 to quantify Aβ deposition in AD mouse models, revealing strain-specific patterns.

This study shows NG2 glia are essential for maintaining microglia homeostasis and presents a method to deplete NG2 glia in vitro and in vivo.

This study demonstrates that peptoid-conjugated beads can capture and transmit prion infectivity from blood, validating a sensitive assay for prion detection.

The paper introduces mesoSPIM, an open-source light-sheet microscope initiative for imaging large cleared tissue samples with near-isotropic resolution.

This study shows that SARM1 deficiency accelerates prion disease progression by upregulating XAF1, leading to increased neuronal apoptosis.

This study investigates the role of Del-1 in prion disease progression and finds that its absence does not affect prion pathogenesis, clearance, or neuroinflammation in mice.

This paper introduces a bispecific antibody that targets both the globular domain and flexible tail of PrP, preventing prion toxicity and oligomer formation.