The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

Alzheimer s & Dementia · Aug 28, 2024Peer-reviewedGenetic & Genomic Medicine

Genome-wide association study of Alzheimer's disease brain imaging biomarkers and neuropsychological phenotypes in the EMIF-AD Multimodal Biomarker Discovery dataset

Jan Homann, Tim Osburg, Olena Ohlei, Valerija Dobričić, Laura Deecke, Isabelle Bos, Rik R. Vandenberghe, Silvy Gabel, Philip Scheltens, Charlotte Elisabeth Teunissen, Sebastiaan Engelborghs, Giovanni Battista Frisoni, Olivier J. Blin, Jill C. Richardson, Régis Bordet, , Lars Bertram

This study performs GWAS on quantitative AD biomarkers and cognitive traits, identifying new loci associated with memory performance and cognitive decline.

Frontiers in Aging Neuroscience · Mar 21, 2022Peer-reviewedGenetic & Genomic Medicine

Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

Giuseppe Fanelli, Barbara Franke, Ward De Witte, I. Hyun Ruisch, Jan Haavik, Veerle van Gils, Willemijn J. Jansen, Stephanie J. B. Vos, Lars Lind, Jan K. Buitelaar, Tobias Banaschewski, Søren Dalsgaard, Alessandro Serretti, Nina Roth Mota, Geert Poelmans, Janita Bralten

The paper investigates genetic overlaps between neuropsychiatric disorders and insulin-related diseases, finding significant genetic correlations and suggesting potential clusters of disorders with divergent pleiotropic effects.

Translational Psychiatry · Feb 14, 2022Peer-reviewedGenetic & Genomic Medicine

TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

Shengjun Hong, Valerija Dobričić, Olena Ohlei, Isabelle Bos, Stephanie J. B. Vos, Dmitry Prokopenko, Betty Marije Tijms, Ulf Andréasson, Kaj Blennow, Rik R. Vandenberghe, Silvy Gabel, Philip Scheltens, Charlotte Elisabeth Teunissen, Sebastiaan Engelborghs, Giovanni Battista Frisoni, , Lars Bertram

The paper conducts GWAS on CSF Alzheimer's disease biomarkers, identifying genetic associations with NF-L, YKL-40, and Ng levels.

Alzheimer s & Dementia · May 14, 2021Peer-reviewedGenomics

Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

Shengjun Hong, Dmitry Prokopenko, Valerija Dobričić, Fabian Kilpert, Isabelle Bos, Stephanie J. B. Vos, Betty Marije Tijms, Ulf Andréasson, Kaj Blennow, Rik R. Vandenberghe, Isabelle Cleynen, Silvy Gabel, Jolien M. Schaeverbeke, Philip Scheltens, Charlotte Elisabeth Teunissen, , Lars Bertram

The paper conducts a genome-wide association study (GWAS) on Alzheimer’s disease CSF biomarkers in the EMIF-AD dataset, identifying novel genetic signals and confirming existing associations.

Translational Psychiatry · Nov 22, 2020Peer-reviewedGenomics