Author

Christian Hock

Thermo Fisher Scientific (Germany)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Systems Biology· 3

Signature Assays, Organisms & Methods

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Assay:proteomics· 7 Approach:experimental assay· 6 Organism:human· 6 Research Focus:benchmarking· 5 Organism:yeast· 3 Research Focus:variant calling· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Vlad ZabrouskoviD· 7 shared Eduard V. Denisov· 6 shared Eugen DamociD· 6 shared Tabiwang N. ArreyiD· 6 shared Alexander MakaroviD· 5 shared Hamish I. StewartiD· 5 shared J. Petzoldt· 5 shared Amelia C. Peterson· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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7 shared papersBiochemistry

Vlad ZabrouskovORCID

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Author profile →

7 papers

Recent·Most cited

High Resolution Multi-Pass Astral Analyzer Quantification Enables Highly Multiplexed 35-Plex Tandem Mass Tag Proteomics

Hamish Stewart, Steven R. Shuken, Christopher Rathje, Julia Kraegenbring, Martin Zeller, Tabiwang N. Arrey, Bernd Hagedorn, Eduard V. Denisov, Robert Ostermann, Dmitry Grinfeld, J. Petzoldt, Daniel Mourad, Philipp Cochems, Florian Bonn, Bernard Delanghe, , Steven P. Gygi

This paper introduces a high-resolution multi-pass Astral analyzer mode for TMT proteomics, enabling 35-plex quantification with improved depth and precision.

bioRxiv · Feb 26, 2026 · PreprintBiochemistry

Higher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer

Ulises H. Guzmán, Martin Rykær, Ivo Alexander Hendriks, Hamish I. Stewart, Eduard V. Denisov, Bernd Hagedorn, J. Petzoldt, Arne Kreutzmann, Yannick Mueller, Tabiwang N. Arrey, Immo Colonius, Ole Østergaard, Claire Koenig, Julia Kraegenbring, Kyle L. Fort, , Jesper.V. Olsen

Orbitrap Astral Zoom upgrades enable 270 Hz DIA scanning, identifying 7184 protein groups at 500 samples/day and >12,000 proteins from fractionated HEK293 in 2.7 h.

Molecular & Cellular Proteomics · Jan 10, 2026Peer-reviewedBiochemistry✦ In-depth digest

Evaluation of a prototype Orbitrap Astral Zoom mass spectrometer for quantitative proteomics - Beyond identification lists

Chris Hsu, Nicholas Shulman, Hamish I. Stewart, J. Petzoldt, Anna Pashkova, Deanna L. Plubell, Eduard V. Denisov, Bernd Hagedorn, Nicolaie Eugen Damoc, Brendan MacLean, Philip M. Remes, Jesse D. Canterbury, Alexander Makarov, Christian Hock, Vlad Zabrouskov, , Michael J. MacCoss

This paper evaluates a prototype Orbitrap Astral Zoom mass spectrometer for quantitative proteomics, showing improved performance in ion detection and quantitative precision compared to the standard Orbitrap Astral MS.

Journal of Proteome Research · Oct 22, 2025Peer-reviewedBiochemistry

Quantitative Label-Free Single-Cell Proteomics on the Orbitrap Astral MS

Valdemaras Petrosius, Pedro Aragon-Fernandez, Tabiwang N. Arrey, Jakob Woessmann, Nil Üresin, Bauke de Boer, Jinyu Su, Benjamin Furtwängler, Hamish I. Stewart, Eduard V. Denisov, Johannes Petzoldt, Amelia C. Peterson, Christian Hock, Eugen Damoc, Alexander Makarov, , Erwin M. Schoof

This study evaluates the Orbitrap Astral MS's sensitivity for single-cell proteomics, showing improved proteome coverage and quantitative accuracy in low-input samples.

Molecular & Cellular Proteomics · May 5, 2025Peer-reviewedBiochemistry

Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer

Noah M. Lancaster, Pavel G. Sinitcyn, Patrick Forny, Trenton M. Peters-Clarke, Caroline Fecher, Andrew J. Smith, Evgenia Shishkova, Tabiwang N. Arrey, Anna Pashkova, Margaret Lea Robinson, Nicholas L. Arp, Jing Fan, Juli Hansen, Andrea Galmozzi, Lia R. Serrano, , Joshua J. Coon

The paper introduces a method using the Orbitrap Astral mass spectrometer with DIA to rapidly analyze phosphoproteomes, detecting over 80,000 phosphorylation sites in mice.

Nature Communications · Aug 15, 2024Peer-reviewedSystems Biology

Evaluating the capabilities of the Astral mass analyzer for single-cell proteomics

Valdemaras Petrosius, Pedro Aragon-Fernandez, Tabiwang N. Arrey, Nil Üresin, Benjamin Furtwängler, Hamish Stewart, Eduard V. Denisov, J. Petzoldt, Amelia C. Peterson, Christian Hock, Eugen Damoc, Alexander Makarov, Vlad Zabrouskov, Bo Torben Porse, Erwin M. Schoof

This study evaluates the Astral mass analyzer's performance in single-cell proteomics using DIA, showing improved proteome depth and quantitative precision for ultra-low input samples.

bioRxiv · Jun 6, 2023 · PreprintSystems Biology

Narrow-window DIA: Ultra-fast quantitative analysis of comprehensive proteomes with high sequencing depth

Ulises H. Guzmán, Ana Martínez‐Val, Zilu Ye, Eugen Damoc, Tabiwang N. Arrey, Anna Pashkova, Eduard V. Denisov, J. Petzoldt, Amelia C. Peterson, Florian Harking, Ole Østergaard, Hamish I. Stewart, Yue Xuan, Daniel J. Hermanson, Christian Hock, , Jesper Velgaard Olsen

The paper introduces Narrow-window DIA, a fast proteomics method enabling high-throughput and comprehensive proteome analysis with high precision and accuracy.

bioRxiv · Jun 2, 2023 · PreprintSystems Biology