Kwanghun Chung

An integrated multi-omic atlas of the choroid plexus highlights conserved molecular programs of epithelial function

This study integrates multi-omic data from mouse and human choroid plexus to identify conserved molecular programs of epithelial function across species.

The noncoding circular RNA circHomer1 regulates synaptic development and experience-dependent plasticity in mouse visual cortex

This study identifies circHomer1 as a circRNA critical for synaptic development and experience-dependent plasticity in mouse visual cortex through transcriptome analysis and knockdown experiments.

Functional dissection of neural circuitry using a genetic reporter for fMRI

This paper introduces a genetic probe to selectively image neural circuits in rats using fMRI, revealing diverse projection sources to the striatum and informing a model of striatal function.

Cellular Anatomy of the Mouse Primary Motor Cortex

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

Divergent pallidal pathways underlying distinct Parkinsonian behavioral deficits

The paper identifies two distinct GPe-PV neuron pathways in mice and shows they contribute to different Parkinsonian symptoms through differential electrophysiological responses to dopamine depletion.

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genes

This study uses human brain organoids to show that ASD risk genes cause accelerated development of specific cortical neuron classes.

Brain-wide mapping of contextual fear memory engram ensembles supports the dispersed engram complex hypothesis

The paper maps contextual fear memory engrams across 409 brain regions and supports the dispersed engram complex hypothesis through optogenetic and chemogenetic experiments.

3D Mapping Reveals Network-specific Amyloid Progression and Subcortical Susceptibility.

This study maps Aβ deposition in a mouse model and postmortem human tissue, showing subcortical structures are early and vulnerable to Aβ accumulation and network spread.