Taekjip Ha

This paper develops a Bayesian framework to analyze smFRET data and separate PIFE effects from FRET efficiency changes using fluorescence lifetime signals.

This paper introduces sgGOLDFISH, a method for single-nucleotide sensitivity in direct hybridization genome imaging, and demonstrates its application in identifying and localizing point mutations in progeroid fibroblasts.

The paper tracks single mRNA translation in live cells, revealing that translation occurs in bursts and is influenced by 5' UTR structure and environmental signals.

This study identifies that pathological α-synuclein destabilizes the TSC1-TSC2 complex, activates mTORC1, and enhances protein translation, contributing to neurodegeneration in Parkinson's disease.

The paper shows that Dynamin 1xA forms molecular condensates with Syndapin 1 at endocytic sites, enabling ultrafast endocytosis by bypassing the recruitment step.

The paper shows that Dynamin 1xA and Syndapin 1 form liquid-like condensates at synapses, which facilitate ultrafast endocytosis by enabling molecular crowding and intermolecular interactions.

The paper introduces InterSpy, a synthetic biology tool that forms membrane-membrane interfaces using SpyTag/SpyCatcher, and demonstrates its function in cell-free systems and cells.

This paper identifies hOrc6's role in promoting S-phase progression by facilitating mismatch repair complex assembly and activity at the replication fork.

This study investigates how single base-pair changes affect the in vivo kinetics of sRNA-target interactions, showing that Hfq facilitates annealing and buffers base-pair disruptions.

The paper uses single-molecule FRET to study how mismatches affect Cas9-RNA DNA binding and rejection kinetics, revealing that proximal mismatches lead to rapid rejection while distal mismatches allow stable complex formation.