J. Chen

Sorbitol promotes early flower bud differentiation in loquat by upregulating the MADS-box transcription factor EjCAL through the ERF12 regulatory pathway.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This paper introduces label-retention expansion microscopy (LR-ExM) to prevent fluorescence signal loss and enable high-efficiency labeling, achieving molecular resolution in visualizing clathrin-coated pits.

This study shows that BCL6 helps cancer cells survive genotoxic stress by repressing PTEN and enhancing interferon responses, suggesting BCL6 inhibition could improve cancer treatment.

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

This study identifies Rnd3 as a protective factor in placental mitochondria through PPARγ-UCP2 signaling, showing its role in mitigating oxidative stress in preeclampsia.

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

The paper investigates off-target mutations caused by prime editors and finds no observable gRNA-independent off-target effects in transfected human cells.

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

The paper identifies imprinted genes in flax endosperm and shows their role in intraspecific variation and domestication.

This study contrasts the population structure and demographic history of two cereal aphid species in different agricultural landscapes, revealing distinct genetic patterns and potential responses to human-induced environmental changes.

This study shows Nrf1 represses tumor growth by inhibiting Wnt/β-catenin signaling and other pathways through ubiquitination of β-catenin and regulation of key genes.

The paper investigates phage-bacteria coexistence and co-propagation by combining experiments and modeling, revealing a sector-shaped lysis pattern indicative of co-propagation and showing it depends on intrinsic properties, not external factors.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

NUFEB simulates microbial community dynamics using individual-based modeling, supporting large-scale simulations and detailed biological, chemical, and physical processes.

This study demonstrates that transient expression of Runx1 and Hoxa9 in pluripotent stem cells generates functional T cells capable of immune surveillance and tumor eradication.

This paper demonstrates the use of a ClyA nanopore to monitor conformational changes of maltose-binding protein (MBP) in real time, revealing three distinct ligand-bound states corresponding to different reducing sugar isomers.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.