statistical model

Anticipatory Threat of Shock Reduces the Number of Items Reported From a Brief Visual Display: Evidence for Capacity Loss Along the Scanning Order

The paper shows that anticipating a shock reduces the number of items remembered from a visual display, with greater loss in later positions.

BioTrajX: evaluating biological plausibility in single-cell trajectory inference

BioTrajX evaluates biological plausibility of single-cell trajectories using three metrics to compare different trajectory inference results.

Enhancers Silence Coupled-coding RNAs in Animals

The paper identifies regulatory non-coding genes marked by nucleosome arginine methylation and regulated by JMJD5, showing their coupling with coding genes in animals.

A population-based resource for the prioritization of rare variants of unknown significance in clinical genomics

The paper identifies rare founder variants in a population and develops a platform for variant prioritization, showing that some pathogenic variants may be missed by conventional methods.

Temporal genomic imprinting regulates grain filling in barley

The paper identifies imprinted genes in barley endosperm and shows how LYS3 regulates grain filling through maternal and paternal allele expression.

Cross-species epigenomic signatures of exceptional longevity: Insights from Jonathan the Giant Tortoise and human centenarians

This study compares epigenomic signatures of longevity between a giant tortoise and humans, finding shared methylation patterns linked to telomere biology.

Basal ganglia output guides decision-making by state destabilization

The paper shows that basal ganglia output in zebrafish destabilizes neural activity states to guide decision-making in a Go/No-go task.

Calves function as social magnets in a species with high fission-fusion dynamics, the Asian elephant

The study finds that calf presence in Asian elephant groups increases group size and social associations, suggesting calves promote sociality through collective defense and allomaternal care.

A Phenomenological Model of Synaptic Activity in the Blowfly Lamina

The paper develops a phenomenological model to explain vesicle release regularization in blowfly lamina synapses by incorporating physiological parameters and findings from previous studies.

Competence repression by the SPβ prophage in Bacillus subtilis revealed by transcriptomics across culture conditions

The paper uses transcriptomics to show that SPβ prophage represses competence in Bacillus subtilis under competence-inducing conditions, reducing DNA uptake and evolvability.

Representation-aware calibration enables statistically reliable protein structure search

Struct-Caliper improves protein structure search reliability by providing accurate p-values, increasing homolog recovery and reducing false discoveries compared to native E-values.

Social ties are maintained through sensory adaptations in green chromides

The paper investigates how visual gene expression changes in green chromides under different light environments and how these changes relate to stable conspecific preferences.

Loneliness as a modulator of intersubject neural alignment across social and nonsocial contexts

This study examines how loneliness affects neural synchrony during social and nonsocial tasks, finding idiosyncratic responses in lonely individuals and greater synchrony in specific brain regions.

Gene expression in Anolis sagrei suggests conservation of patterning mechanisms drives formation of two high acuity areas

The paper identifies conserved gene expression patterns in the retina of Anolis sagrei that suggest shared developmental mechanisms for forming multiple high acuity areas.

Adaptation and conservation of turtle visual opsins over a deep phylogenetic divergence

This study investigates visual opsin evolution in turtles using transcriptomic and genomic data from 59 species, revealing conserved sequences and habitat-driven selective pressures.

KDRD: assessing discovery replicability based on summary association statistics from a single study

KDRD estimates replicability of associations using summary statistics from a single study, showing moderate to high replicability for 33 of 45 brain-related traits in proteomics analyses.

A trustworthy semantic knowledge network linking data-driven cell phenotypes to diseases and drugs

The paper develops NLM-CKN, a semantic knowledge network linking cell phenotypes to diseases and drugs using integrated data from 88 datasets.

Biological Signaling Pathways Associated with Late Tendon Development in Chicken Embryos and Their Dependence on Mechanical Stimulation

This study identifies mechanotransduction pathways involved in chicken tendon development and shows how paralysis disrupts these processes.

Effects of Reduced Watering Regimes on Hops Growth and Rhizospheric Microbial Communities

This study examines how reduced watering affects hops growth and rhizospheric microbial communities across five cultivars, finding differential plant responses and consistent microbial associations with cultivar type.

Optimizing the efficiency of assisted reproduction procedures in the common marmoset (Callithrix jacchus) improved IVF outcomes

This study optimizes IVF procedures in common marmosets by identifying factors like progesterone levels and stimulation duration that improve embryo development and implantation rates.

Species identity rather than colony size partitions shape variation in six Caribbean octocorals

The paper examines colony shape variation in Caribbean octocorals, finding that species identity, not colony size, primarily determines shape differences.

Topographic reference modelling of white matter hyperintensities across the adult lifespan

This paper introduces vTRM, a framework to characterize WMH spatial patterns across age and sex, revealing distinct associations with aging, vascular, and neurodegenerative processes.

When perfect is a warning: explanations expose shortcuts that accuracy hides in cancer gene-expression classifiers

The paper shows cancer classifiers can achieve perfect accuracy by learning data source shortcuts rather than biological features, and introduces a method to detect and mitigate this issue.

A compact motif vocabulary is differentially interpreted across human cell types

The paper shows that a compact set of regulatory motifs can explain gene expression across diverse human cell types through context-dependent interpretation.

Distinct antischistosomal profiles of antimalarials and TRP agonists

This study compares the antischistosomal effects of antimalarials and TRP agonists using RNA-seq and efficacy tests in mice, finding distinct transcriptional responses and retained activity against praziquantel-resistant parasites.

Mapping brain networks underlying abstract perceptual decision formation and its EEG signatures

The paper identifies a supramodal brain network involved in perceptual decision formation and links it to the EEG centroparietal positivity (CPP) signal using fMRI and EEG data.

Structure-Based Discovery of GTP-Enhanced Rab10 Modulators and Their Effects on Alzheimer Disease-Relevant Cellular Phenotypes

The paper identifies Rab10 modulators through virtual screening and evaluates their effects on Alzheimer's disease-related cellular phenotypes.

Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition

This study identifies factors influencing Sleeping Beauty transposition, showing chromatin context, cargo size, and transcriptional activity affect efficiency and reintegration patterns.

HLAResolver: A statistical framework for resolving HLA ambiguity in T-cell response data

HLAResolver improves HLA resolution in T-cell response data by integrating MIRA responses with NetMHCpan predictions, achieving higher sensitivity and fewer candidate HLAs.

Photoentrainment as Bayesian Inference: How the central circadian clock may weight and integrate the intensity and wavelength of natural light to estimate astronomical time

The paper proposes a Bayesian model explaining how the circadian clock integrates light intensity and wavelength to estimate astronomical time despite natural variability.