wet-lab / biochemical assay

This study identifies RAPSYN-mediated neddylation of BCR-ABL as a mechanism driving Ph+ leukemia progression and presents it as a therapeutic target.

The paper shows that mRNA location and translation rate influence protein targeting to multiple destinations by modulating interactions with scaffold proteins and importins.

This study shows that the agr quorum-sensing system in Staphylococcus aureus primes the bacteria to resist oxidative stress by controlling reactive oxygen species, even when the system is not actively activated.

This paper develops a human DMD model using MYOrganoids to study fibroblast inclusion effects and evaluates microdystrophin therapy efficacy, finding limited success in reducing fibrosis and improving membrane stability.

This study shows fungal small RNAs are secreted via extracellular vesicles and enter plant cells through clathrin-mediated endocytosis, using BcPLS1 as an EV biomarker.

This study identifies two distinct neutrophil states in mice and patients, driven by actin dynamics and NF-kB/STAT3 signaling, with different functional outcomes.

The paper identifies a nuclear quality control pathway that degrades mislocalized secretory proteins to prevent cytosolic proteostasis decline.

This paper develops a self-healing spider silk material with tunable properties and demonstrates its application in wearable electronics.

This study identifies histone H1.2 as the carrier for PAR translocation from the nucleus to the cytosol, initiating parthanatos, and shows its role in neuronal injury models.

This study identifies NOP16 as a histone mimic that regulates H3K27 methylation and gene repression, showing its role in breast cancer progression.

This study shows MSI2 promotes lung tumorigenesis by enhancing ATM expression and DNA damage response, suggesting MSI2 as a potential therapeutic target in lung cancer.

This study shows that GpsB phosphorylation by PrkA regulates peptidoglycan synthesis and cytosolic survival in L. monocytogenes under cell wall stress.

The paper investigates how basic residues modulate phosphorylation sites in the SNRE of c-Src using NMR and mutations, revealing electrostatic interactions and their effects on conformation.

This study shows that the mitochondrial Ca2+ channel MCU supports tumor growth by enabling cell cycle progression and proliferation through mitochondrial Ca2+ uptake, despite unchanged mitochondrial function.

This study characterizes Morreton virus (MORV) as a safe and effective oncolytic virotherapy for liver cancers, showing tumor regression in animal models with lower doses than VSV.

This study identifies a Pigment-Dispersing Factor (PDF) in pea aphids, showing its presence in circadian clock neurons and potential role in photoperiodic signaling to insulin-producing cells.

This study shows that CCL28 mobilizes HSV-specific memory B and T cells in vaginal mucosa, providing protection against genital herpes.

This study shows that mutations in HRas C-terminal cysteines affect its subcellular localization and signaling, and that 15d-PGJ2 from senescent cells inhibits myoblast differentiation via HRas Cys184.

This study shows kaempferide induces apoptosis in cervical cancer by reducing HPV oncoproteins E6 and E7 and increasing tumor suppressors.

This paper identifies leptin receptor-expressing sympathetic perineurial cells that produce IL33, which prevents BAT inflammation and obesity by supporting thermogenesis and immune regulation.

This study shows that reducing ACSVL3 expression in U87 glioma cells slows their growth and tumor formation in mice by altering the cell cycle without affecting apoptosis.

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

This study shows ATR protects CENP-A occupancy at centromeres by regulating DAXX association with PML nuclear bodies, maintaining genome stability.

The paper identifies a photoreceptor, PLP, that inhibits ascorbate biosynthesis by interacting with GGP, and shows blue light deactivates PLP to promote ascorbate synthesis in tomato.

This study shows RAD52 prevents Polα-dependent replication gaps by enabling RAD51/Pol repriming at reversed replication forks, which limits DNA damage and improves cell viability during replication stress.

The paper identifies cytosolic regions in Hrd1 critical for lumenal ERAD substrate degradation through deep mutational scanning and functional assays.

This study shows that endosome dysfunction causes TLR7 gain-of-function and contributes to human lupus by disrupting TLR7 turnover and leading to self-reactivity.

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.