wet-lab / biochemical assay

This study shows that combining low-dose WEE1 and PKMYT1 inhibition synergistically kills ovarian cancer cells by increasing genomic instability and inflammation, and is well-tolerated in mice.

This study shows that Fzd9 overexpression rescues SMG-induced osteoblast dysfunction by activating YAP through actin polymerization and nuclear translocation.

This study shows that physical confinement reduces SOX17 expression in hiPSCs spheroids during gastrulation, but time-softening hydrogels rescue this effect.

The paper studies how local interaction rules change during development and evolution in Mexican tetra fish, showing surface fish develop schooling behavior through alignment and attraction, while cavefish lose schooling behavior.

This study identifies primate TRIM34 as a lentiviral restriction factor that requires TRIM5 for activity, restricting multiple SIV capsids across primate species.

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

The paper identifies EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling through siRNA screening and pharmacological inhibition.

This study shows CHOP promotes cell death in some cells and proliferation in others during ER stress, providing a competitive growth advantage through stress-specific adaptation.

This study shows GD2 and its biosynthetic enzyme GD3S promote prostate cancer tumorigenesis by maintaining cancer stem cells and EMT markers.

This study identifies BCL7 proteins as nucleosome-binding subunits of the mSWI/SNF complex and shows cancer mutations reduce their affinity for nucleosomes.

This study investigates the role of transketolase in maintaining pyridine nucleotide levels in E. coli by analyzing growth phenotypes and metabolic changes under different conditions.

This study identifies a novel role for MINA in coupling epithelial membrane integrity to nucleolar ribosome biogenesis through its interaction with MPP6.

The paper shows that cell shrinkage via voltage and water regulation determines which epithelial cells are extruded in crowded conditions.

This study identifies how phosphorylation regulates motor-PRC1 complexes to coordinate chromosome segregation and cytokinesis during mitosis.

This study characterizes a mouse model of ICF syndrome, revealing that Zbtb24 deficiency leads to hypogammaglobulinemia via enhanced CD19 activation and IL-5 signaling.

The paper identifies KCNN4 as a mediator linking PIEZO mechanotransduction to NLRP3 inflammasome activation, showing its role in CAPS-related auto-inflammation.

This study shows that O-GlcNAc modification of α-Synuclein leads to amyloid fibrils with reduced seeding activity and pathology in Parkinson's disease models.

This study shows calorie restriction increases gastric ghrelin cells via a Notch-FOXO1 pathway, involving stem cell proliferation and differentiation changes.

The paper shows that cytotoxic CD4+ T cells eliminate senescent fibroblasts by targeting HCMV-gB antigen expressed on these cells, reducing their accumulation in old skin.

The paper shows that type-I conventional dendritic cells enhance checkpoint blockade immunotherapy effectiveness in pancreatic cancer when combined with pancreatitis.

The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.

This study shows that butyrate-producing bacteria epigenetically control tuft cell differentiation via HDAC3, influencing type 2 immunity and helminth responses.

This study identifies MOTS-c, a mitochondrial-encoded host defense peptide with antibacterial and immunomodulatory functions, showing that the immune system is encoded by both nuclear and mitochondrial genomes.

This paper develops a T cell engager that uses IFNγ to upregulate CD38 on leukemia stem cells, enabling their targeting and depletion in AML.

This study identifies NuSAP's role in regulating metaphase spindle length by controlling microtubule flux and Kif2A localization during mitosis.

The paper shows FOXP3+ Treg use heparanase to access IL-2 bound to ECM in inflamed tissues, enhancing their function and stability.

This study characterizes intracellular Aβ42 in normal rat and human brains, showing its presence in specific brain regions and supporting the idea that AD models reflect quantitative rather than qualitative differences in Aβ42 accumulation.

This study identifies CRB3's role in navigating Rab11 vesicles to promote γTuRC assembly during ciliogenesis and its regulation of Hh and Wnt signaling in tumorigenesis.

This study shows Rab7 regulates CLCA1 in goblet cells, affecting mucus composition and gut microbiota, leading to increased susceptibility to colitis.

This study shows that enhancing branched-chain amino acid metabolism improves reproductive function in aging C. elegans by maintaining oocyte quality.