mouse

This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.

This study identifies an endothelial-specific Ovol1 variant that upregulates Slug and drives pathological angiogenesis in disease models.

DEEPNET-LLM predicts unknown metabolite structures from mass spectra by leveraging molecular neighborhoods, achieving high accuracy in de novo structure prediction.

This study identifies Blp4 as a Cryptococcus neoformans antigen that elicits B cell-dependent protective immunity in mice and antibody responses in human cryptococcosis survivors.

The paper shows that dermal-epidermal junction geometry influences stem cell fate in mouse skin, with concave areas promoting proliferation and convex areas promoting differentiation.

This study shows that standard touchscreen testing in mice shifts circadian rhythms and proposes a modified protocol to reduce these effects without affecting cognitive performance.

This study shows that CTLA-4 signaling impairs antibody quality during Borrelia infection by affecting germinal center dynamics and T cell responses in mice.

This paper develops a mouse model of metastasis-induced breast cancer cachexia and identifies that anorexia drives tissue wasting while muscle weakness is independent of food intake.

The paper analyzes the dynamics of a whole-mouse-brain neural mass model coupled via an empirical connectome, finding chaotic oscillations and suppression of chaos with network modifications.

This study shows that mitovesicles from Alzheimer's disease mouse models undergo stage-specific proteomic changes that reflect mitochondrial dysfunction and provide a conserved disease signature in humans.

This study identifies Yap as a critical regulator of tracheoesophageal separation during foregut development, showing that its loss causes a distinct Type A EA/TEF phenotype.

The paper investigates how oligodendrocytes contribute to the formation of α-synuclein filaments in multiple system atrophy by comparing seeded aggregation in different cell types.

TileScope quantifies spatial gene expression relationships beyond simple colocalization, distinguishing regional enrichment from internal covariation in glioblastoma and other tissues.

This study shows monounsaturated fats reduce cholesterol crystals in lipid droplets, while saturated fats promote their formation in mice with MASH.

This study compares cortical interneuron migration across species, finding that human interneurons migrate slower and more dispersedly due to CCP1-dependent changes in microtubule dynamics.

scSTEC directly annotates chromatin subcompartments from individual single-cell Hi-C matrices without imputation or cross-cell sharing, achieving results comparable to scGHOST with greater interpretability.

This study shows that myelin affects hippocampal network function by shaping extracellular space, not only by insulating axons, with demyelination altering diffusion, flow, and synaptic transmission.

GSET retrieves dynamic gene signals to improve mechanistic GRN inference by identifying bridge genes involved in cell-state transitions.

This paper introduces a geometric framework for analyzing local field potentials (LFPs) by modeling their dynamics as low-dimensional K-tori and validates it across neural datasets.

This study shows that Polycomb-marked promoter methylation gains in aging and cancer occur independently of replication and are driven by age-related epigenetic drift rather than oncogenic signaling.

This study evaluates a mucosal vaccine combining ACP and diABZI, showing enhanced TH1/TH17 responses and serum bactericidal activity against Neisseria gonorrhoeae.

This paper discovers a novel 5-HT2A receptor-linked signaling pathway involving NAADP-mediated lysosomal Ca2+ release, showing reduced hallucinogenic and neuroplastic effects upon genetic ablation of the pathway in mice.

This study shows that aging increases spinal noradrenergic activity, leading to motor neuron hyperexcitability and sarcopenia, which can be reversed by suppressing noradrenergic signaling.

The paper identifies a self-renewing lymphoid-biased HSC subset in mice that maintains lymphopoiesis during aging and may serve as a backup source for immune function.

This study shows aging causes bidirectional transcriptional changes in cardiac immune cells during LPS-induced endotoxemia, with shared mitochondrial remodeling and cell-type-specific functional shifts.

This study identifies adipocyte Kindlin-2 as a regulator of skin wound healing through an endocrine axis involving E-cadherin, β-catenin, and IGFBP2.

This study shows norepinephrine inhibits excitatory synaptic transmission from solitary tract afferents to NTS catecholamine neurons in mice, with a presynaptic mechanism involving alpha-adrenergic receptors.

This study shows that high-intensity interval training reduces tremor frequency in a mouse model of essential tremor, while resistance training and sedentary behavior do not.

ExPert infers causal perturbations from cell states by learning prototypes across 12 contexts, achieving high recall with low compute and validating findings in disease models.

The paper investigates how bat cells respond to Toxoplasma gondii infection, finding delayed host transcriptional activation despite efficient parasite replication.