T-cell and B-cell Immunology

This study shows that thymic imprinting causes naive CD4 T cells to have different cytokine responses, leading to varied Treg induction and effector function.

The paper shows that T cells entering the eye develop either suppressive regulatory or anergic phenotypes, with both arising from a common precursor, revealing a key checkpoint in ocular immune privilege.

This paper shows that T-cell receptor signaling uses condensate nucleation to selectively detect single foreign peptides by amplifying weak signals and setting spatial-temporal thresholds.

The paper identifies RORγt+ antigen-presenting cells as the exclusive inducers of food-specific regulatory T cells, which interact with cDC1 to regulate CD8β T cell responses in the intestine.

This study shows HDAC1 is essential for generating and maintaining CX3CR1+ effector-like T cells during chronic viral infection, which helps control viral load.

This study shows that physical activity alters the metabolic profiles of CD4+ and CD8+ T cells in older adults, both at rest and upon activation, potentially improving T cell function.

This study shows IL-1β signaling affects Tfh and Tfr cells in human lymphoid tissues, linking it to autoantibody production and autoimmune disease.

This study identifies Thetis cells IV as essential for food-specific Treg cell differentiation and oral tolerance, highlighting their distinct role from dendritic cells in immune regulation.

This study shows that Gfi1 regulates the formation of exhausted effector-like CD8 T cells during chronic infection and cancer, impacting their differentiation and function.

This study shows that γδ T cells help protect chickens early against Salmonella infection, but their role is replaced by other cells later.

This study shows PIM kinases selectively regulate IL-2-driven protein synthesis and trafficking in CD8 T cells, without major effects on transcriptional programs.

This study shows that antigen mobility affects B cell immune synapse dynamics and antigen capture efficiency, with high-mobility antigens being extracted faster and with better affinity discrimination.

This study identifies GM-CSF-producing helper T cells as drivers of immunopathology, showing Treg cells restrain them to prevent tissue damage in mice.

This study uses single-cell RNA-sequencing to analyze human iNKT cells from multiple tissues, identifying novel transcriptional patterns and subsets not previously described in mice.

The paper shows that AIM assays overestimate Ag-specific CD4+ T cells due to TCR-independent activation and introduces a modified assay using CXCR4-CD137+ cells for accurate characterization.

This study investigates how rapamycin modulates lymph node architecture, leukocyte trafficking, and gut microbiome over time, revealing a novel mechanism of immunosuppression.

The paper introduces a microwell array-based thymic organoid model that supports T-cell development and is suitable for high-throughput analysis.

This study identifies Prdm16-dependent tolerogenic dendritic cells (tDC) that induce regulatory T cells to promote oral tolerance to food and microbiota antigens in mice and humans.

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

The paper compares the mechanical behavior of two TCRs recognizing the same pMHC using MD simulations, showing differences in load response due to dynamic allostery.

This paper introduces TCR-Track, a method to map and track helper T cell subsets in scRNA-Seq data, revealing their clonal relationships and functional programs over time.

The paper shows that T cell-derived IFN-γ suppresses TFH differentiation and antibody responses by acting through dendritic cells, not directly on CD4+ T cells.

This study identifies novel microbial epitopes recognized by CD4+ T cells using the MCR system, revealing polyreactivity and broad conservation across gut bacteria.

This study shows that deleting both ZFP36L1 and ZFP36L2 in T cells greatly increases cytokine production but reduces cell viability and signaling.

This study shows that FOXP3+ Treg cells use TBET to control activated CD8+ T cells during influenza recovery, but not Trm cell generation.

This study shows that IFNγ and IL-27 enhance Tr1 cell development during strong TCR signaling in a mouse model.

The paper develops ferret immune repertoire reference resources and assays using long-read transcriptome sequencing and genome annotation.

The paper uses statistical analysis of TCR repertoire data to show microhomology influences V(D)J recombination outcomes in humans.