HIV Research and Treatment

The paper analyzes HIV-1 entry kinetics across 257 isolates, identifying single-residue determinants and showing cooperative sequential roles of co-receptor engagement and gp41 function in entry.

This study shows PARP-1 deficiency or inhibition increases HIV-1 replication in human CD4+ T cells by enhancing viral infectivity and virion-associated Env levels.

This study investigates how Importin beta-1 packaged in HIV-1 virions affects viral infectivity and transcription, revealing its dual role as both a facilitator and restriction factor.

This study examines how early ART initiation in HIV-infected infants affects antibody development and latent reservoir dynamics, showing their opposing impacts on post-treatment viral rebound.

This paper shows HIV-1 Vpr causes separate G2 and M phase cell cycle arrests that activate distinct DNA damage pathways, with implications for early HIV replication.

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

This study shows HIV integrase compacts viral DNA into biphasic condensates, with the core susceptible to inhibitors and the outer layer resistant.

This study examines changes in immune checkpoints and senescence markers in HIV-positive individuals post-COVID-19 infection, finding elevated levels of several biomarkers in those previously infected.

The paper measures the stoichiometry of Gag-Pol and gp120/gp41 proteins in infectious HIV-1 virions using a competitive assembly method, finding it similar to all released virions.

This study identifies CD34+ monocytes as highly susceptible to HIV-1 infection, showing they harbor more proviral DNA and express higher HIV-1 receptors despite cART.

This paper uses mathematical modeling to show that ADCC targeting Th cells hinders HIV vaccine development by damaging immune responses and reducing vaccine effectiveness.

This study uses graph theory to analyze topological properties of HIV-1 reservoir networks, revealing differences between elite controllers and ART-treated patients.

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

This study identifies RNA aptamers specific to different HIV-1 capsid assembly forms, enabling their purification from cell lysates without virus or host modification.

This study examines the innate immune system in HIV-exposed infected and uninfected infants over 18 months, finding altered immune cell subsets and activation in infected infants, which normalize with ART.

This study shows HIV-1 infects human iPSC-derived microglia, causing sustained type I interferon signaling and disease risk gene expression in a neural model.

The paper evaluates two tools for HIV transmission direction prediction using short and long-read sequencing data from serodiscordant couples, showing long reads improve phylogenetic resolution and transmission prediction accuracy.

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

The paper estimates insertion and deletion rates in HIV-1 gp120 variable loops using longitudinal sequences and coalescent models, finding significant variation in rates and effects on glycosylation.

The paper identifies CCR7+ CD4 T cells in rhesus brain and border tissues, showing their decline during chronic SIV-induced neuroinflammation and their role in CNS immune surveillance.

This study investigates CD4 T cell responses in the CNS during SIV infection in rhesus macaques, revealing their role in viral persistence and immune activation despite ART.

The paper determines the structure of HIV-1 capsid hexamer bound to inhibitor 11l, revealing its binding mechanism and structural impact on the capsid protein.

The paper identifies that some HIV-1 controllers lack actin disruption typical of ARP2/3 inhibition, suggesting a protective mechanism against immune dysfunction.

This study shows HIV-1 infection disrupts cortical actin in CD4+ T cells, mimicking ARP2/3 defects in immunodeficiencies, and identifies ARP2/3 as a potential therapeutic target.

This study investigates how the timing of ART initiation affects viral rebound in infant SHIV-infected Rhesus macaques, finding that latent reservoir size and high-potency neutralizing antibodies influence rebound time.

This study compares the plasma virome of HIV-infected patients on antiretroviral therapy with controls, finding significant differences in viral composition.

The paper examines CD8+ T cells in the colon of HIV patients on ART, finding impaired mitochondrial function and reduced immune responses compared to peripheral blood cells.