Influenza Virus Research Studies

The paper reports a mass mortality event in Black-legged Kittiwakes caused by HPAI H5N1, detailing pathological findings and zoonotic potential.

This study shows that TIV vaccination reduces lethality in influenza-infected mice with secondary pneumococcal infections by modulating immune responses and pathogen titers.

The paper analyzes the spread of H5N1 avian influenza in North America, identifying seasonal patterns and a phase transition linked to mammalian cases and regional viral amplification.

This study shows that antibodies against influenza virus neutralize by interacting with the viral membrane, and disrupting these interactions reduces their effectiveness.

This study shows that alpelisib, a PI3K inhibitor, increases defective viral genomes and particles in A/H3N2 but decreases total particles in A/H1N1, suggesting host metabolism influences viral defectiveness.

This study shows female mice with obesity have stronger influenza vaccine immunity and protection than males, with males showing worse antibody responses and disease outcomes.

This paper develops a framework to estimate pandemic potential from experimental transmission studies by analyzing within-host viral dynamics and extrapolating to epidemiological parameters.

This study shows that H5N1 viruses' ability to adapt to bovine cells varies across genotypes and time, with key mutations in PB2 playing a role.

This study compares the attachment and replication efficiency of a 2022 H5N1 avian influenza virus with a 2005 strain in human respiratory epithelium, finding the 2022 virus replicates more efficiently.

This study generates human monoclonal antibodies against H5N1 clade 2.3.4.4b HA, identifying four that neutralize the virus in vitro and show protective effects in mice.

This study infects alpacas with Influenza C and D viruses, showing subclinical upper respiratory tract infection and suggesting a potential role for camelids in virus ecology.

This study examines how glycan evolution in H3 hemagglutinin affects antigenicity and immunogenicity, showing reduced antibody binding and shifted immune response.

The paper identifies host RNA binding proteins interacting with incoming influenza virus RNA and shows their roles in viral replication.

This study shows vaccine-induced immunity drives antigenic drift in a human-origin H3N2 virus in swine, altering HA receptor binding and glycan specificity.

The paper identifies H5N1 avian influenza virus as the cause of a mass mortality event in Eurasian cranes in Germany in 2025, linked to their social behavior.

This study identifies innate antiviral readiness as a key driver of TSCM cell expansion, showing its predictive value for viral clearance and vaccine design.

The paper identifies distinctive H5N1 viral genome signatures linked to repeated spillovers into U.S. dairy cattle, highlighting genetic diversity and geographic origins.

The paper investigates how adaptive mutations in H5N1 influenza HA affect activation dynamics, showing suppressed fusion peptide dynamics and stabilized subunit interfaces in adapted variants.

The paper uses machine learning to model the spread of H5N1 avian influenza in Europe, finding that ecological factors refine risk predictions beyond climate alone.

Genomic sequencing identified a novel triple-reassortant H5N1 virus in Argentina, highlighting ongoing evolution of clade 2.3.4.4b in the Americas.

This study examines immune responses in ancestrally diverse individuals after influenza vaccination, finding that draining lymph nodes show rapid activation and specific cellular changes.

The paper detects and isolates H5N1 clade 2.3.4.4b avian influenza virus from ticks parasitizing a naturally infected gull, highlighting ticks as potential non-invasive surveillance tools for HPAIV.

This study uses lectin histochemistry to examine sialic acid receptor distribution in mammary glands of livestock and humans, finding SA 2,6-Gal and SA 2,3-Gal receptors that enable IAV binding.

This study uses mutational spectra to infer influenza virus transmission routes and adaptive mutations enabling sustained respiratory transmission.

This study characterizes two non-competing group 2 influenza HA stem antibodies and shows their in vivo protective efficacy despite limited in vitro neutralization.

This study shows that NSUN2-dependent m5C modifications on influenza A virus RNA are essential for proper viral particle assembly and pathogenicity, suggesting m5C depletion could attenuate IAV strains.

This study shows that Grana-type raw milk cheese production inactivates H1N1 and H5N1 influenza viruses, reducing foodborne transmission risk.

The paper investigates how IL-10 signaling interacts with circadian rhythms to influence the host response to influenza infection, finding that blocking IL-10 signaling abolishes time-of-day-specific protection.

The paper shows that balancing viral damage, immune response, and tissue repair can prevent death from lethal influenza by combining antiviral drugs with strategies to enhance epithelial repair.

This study shows that positive selection on influenza A surface antigens has increased over time, driven by immune escape and surveillance, not climate factors.