Pain Mechanisms and Treatments

This study shows that GDNF signaling in muscle afferents enhances both nociception and cardiovascular reflexes following ischemic injury.

This study identifies claudin-12's role in maintaining myelin and blood-nerve barriers, showing its deficiency causes mechanical hypersensitivity and painful neuropathy in male mice.

This study examines gene expression changes in nociceptors distal to spinal cord injury before chronic pain onset, identifying molecular pathways linked to synaptic plasticity and inflammation.

The paper shows excitatory neurons in the spinal dorsal horn are more disinhibited than inhibitory neurons due to chloride dysregulation, despite similar chloride levels, because they rely more on inhibition to balance strong excitation.

This study identifies calretinin-positive neurons in the spinal cord dorsal horn as part of an excitatory network that amplifies pain signals and is a potential target for analgesic therapies.

This paper identifies the P2Y1 receptor's role in regulating non-synaptic cross-depolarization in rat dorsal root ganglia, showing cell-type specific effects and differences in calcium dependence between ganglia.

The paper finds that pain at the ankle biopsy site in HIV-SN patients is associated with lower intra-epidermal nerve fiber density at the ankle compared to the thigh.

This study shows IL-17 from glia suppresses inhibitory synaptic transmission and drives neuropathic pain after chemotherapy.

This study identifies PAG neuronal populations that modulate acute and chronic itch by differentially regulating sensory and affective components through GABAergic and glutamatergic activity.

This study shows TIMP-1 reduces inflammatory pain through both MMP-dependent and receptor-mediated signaling mechanisms.

This study evaluates the pharmacokinetics and analgesic effects of fenobam, an mGlu5 antagonist, in healthy humans, finding variable plasma exposure and minimal analgesic effects at tested doses.

The paper shows that conditioned medium from painful schwannomatosis tumors sensitizes sensory neurons more than nonpainful tumors, indicating secreted factors contribute to pain variability.

The paper investigates how prolonged tonic pain affects intrinsic brain networks in healthy humans, finding altered functional connectivity in pain modulation networks.

This study shows that intense pain reduces brain responses to auditory stimuli during HNCS, suggesting supraspinal mechanisms are involved in pain modulation.

The paper identifies the posterior parietal operculum as a region preferentially activated by heat pain over salient non-painful stimuli using fMRI and behavioral measures.

This study develops a method to achieve long-lasting, non-addictive pain relief by epigenetically repressing NaV1.7 in vivo using CRISPR-dCas9 and zinc finger proteins.

This study identifies Cdkl5's role in pain signaling through its interaction with CaMKII in both human neurons and mouse models of Cdkl5 deficiency disorder.

This study introduces a non-invasive muscle pain model using short-wave diathermy in humans, showing sustained hyperalgesia without significant skin sensitivity changes.

The paper examines aging-related changes in NADPH-diaphorase (NADPH-d) in the spinal cord of aged dogs, identifying megaloneurites in sacral segments that may affect autonomic and sensory nerve pathways.

This study examines the variability in pain threshold perception across individuals and trials, finding a zone of uncertainty where stimulus intensity does not reliably predict pain ratings.

The paper identifies two distinct NADPH-d positive alterations in the sacral spinal cord of aged non-human primates, suggesting they are specialized aging markers in pelvic visceral organs.

The paper investigates the role of the VGLUT2/Cdk5/p25 signaling pathway in inflammatory pain induced by CFA and shows that roscovitine inhibits this pathway.

This study compares aging-related NADPH diaphorase positivity in the spinal cord and medullary oblongata of pigeons with rats and mice, identifying age-related changes and potential markers of aging.

This study identifies GM-CSF's role in bone cancer pain by upregulating voltage-gated sodium channels via Jak2/Stat3 signaling in DRG neurons.

This study shows that PD-1 is required for morphine analgesia and MOR signaling in neurons, with PD-L1 enhancing morphine's pain-relieving effects.

This paper describes a method to selectively photoablate nociceptors in mice using a modified NGF ligand and NIR light, reducing pain behaviors in multiple pain models.

The paper analyzes human tibial nerve transcriptomes to identify sex-dimorphic gene expression related to pain, inflammation, and neuro-immunity.

This study shows that central sensitization increases pupil dilation and brain responses to pinprick stimuli, with pupil dilation being more sensitive than brain potentials.

The paper identifies sex-related gene expression differences in the dorsal root ganglion of male and female rats after nerve injury using RNA-seq.

The paper investigates the removal of chronic pain signs in rats using X-ray microbeam irradiation to disrupt and restore cortical network properties.