Hearing, Cochlea, Tinnitus, Genetics

Perceptual gating of a brainstem reflex facilitates speech understanding in human listeners

The paper shows that the MOC reflex enhances speech understanding by gating auditory signals in degraded or noisy environments, with different brain regions engaged depending on the type of speech challenge.

Improved pure tone sensitivity after simulated hearing loss

The paper shows that simulated hearing loss in Mongolian gerbils leads to improved sensitivity at the notched frequency but not outside, and behavioral signs of phantom sounds.

A backward encoding approach to recover subcortical auditory activity

This paper introduces a backward encoding model to reconstruct auditory brainstem responses from electrophysiological data, showing high correlation between predicted and measured ABRs.

SYNAPTIC RELEASE POTENTIATION AT AGING AUDITORY RIBBON SYNAPSES

The paper investigates age-related changes in auditory ribbon synapses of mice, finding increased synaptic transmission and potential compensation for synapse loss.

Transcription Co-Factor LBH Is Necessary for Maintenance of Stereocilia Bundles and Survival of Cochlear Hair Cells

This study shows that LBH is essential for maintaining cochlear hair cells and stereocilia bundles, with its loss causing progressive hearing loss and OHC degeneration.

Amplification lags nonlinearity in the recovery from reduced endocochlear potential

This study investigates the recovery of cochlear vibrations after reducing the endocochlear potential, finding that amplification requires both active electromotility and physical shifts in operating conditions.

Homeostatic maintenance and age-related functional decline in the Drosophila ear

This study identifies key transcription factors involved in maintaining auditory function in Drosophila and shows their role in age-related hearing loss.

Transcriptome Comparison of organ of Corti in mice, chick and zebrafish

The paper was withdrawn due to lack of full author consent and will not be cited as reference.

A flexible anatomic set of mechanical models for the organ of Corti

The paper develops a flexible mechanical model of the organ of Corti to study how vibrations are transmitted from the basilar membrane to inner hair cells, highlighting cooperative interactions that enhance frequency selectivity and signal amplification.

The effect of noise trauma and high-frequency stimulation on thalamic sensory gating in rodents

This study investigates how noise trauma and high-frequency stimulation affect sensory gating in the thalamic medial geniculate body of rodents, finding that HFS reduces evoked potential amplitudes in noise-exposed animals.

Noncoding microdeletion in mouse Hgf disrupts neural crest migration into the stria vascularis, reduces the endocochlear potential and suggests the neuropathology for human nonsyndromic deafness DFNB39

This paper identifies a noncoding 10bp deletion in Hgf in mice that causes hearing loss by disrupting neural crest migration into the stria vascularis and reducing the endocochlear potential, mirroring human DFNB39 deafness.

A novel stimulus paradigm for simultaneous recording of monaural and binaural frequency following response for identification of binaural interaction component

The paper introduces a novel stimulus paradigm to simultaneously record monaural and binaural frequency following responses to identify the binaural interaction component.

Physiological Basis of noise-induced hearing loss in a tympanal ear

The paper investigates noise-induced hearing loss in locust ears, finding that primary auditory neurons' reduced sound encoding ability is likely due to supporting cell pathologies.

Noise Invariance in Inferior Colliculus Neurons is Dependant on the Input Noisy Conditions

The paper investigates noise invariance in inferior colliculus neurons under different noisy conditions and finds that non-stationary noise uniquely affects neural activity, while white and natural stationary noises produce variable responses.

Local drug delivery to the entire cochlea without breaching its boundaries

The paper introduces a method for uniform drug delivery across the entire cochlea without disrupting its boundaries, overcoming concentration gradient issues.

Mechanotransduction activity facilitates hair cell toxicity caused by the heavy metal cadmium

This study shows that mechanotransduction activity contributes to cadmium-induced hair cell death in zebrafish lateral line cells.

Robust range of auditory periphery development, eye opening, and brain gene expression in Wistar rat pups that experience variation in maternal backgrounds

This study investigates the impact of maternal licking and grooming on auditory development and brain gene expression in Wistar rat pups, finding no effect on hearing onset timing but revealing insights into auditory periphery development and gene regulation.

Radixin modulates stereocilia function and contributes to cochlear amplification

This study shows that radixin is essential for cochlear amplification by modulating stereocilia function and sound-evoked electrical potentials in guinea pigs.

Characterizing Adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq: Validation in the adult mouse and translational implications for the adult human cochlea

The paper characterizes adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq in mice and validates findings in humans, identifying potential mechanisms for cochlear regeneration.

Integration of locomotion and auditory signals in the mouse inferior colliculus

This study shows that IC neurons in mice are modulated by locomotion even without sound, and sound-evoked activity is attenuated during movement, increasing frequency selectivity.

The lhfpl5 ohnologs lhfpl5a and lhfpl5b are required for mechanotransduction in distinct populations of sensory hair cells in zebrafish.

This paper investigates the roles of lhfpl5a and lhfpl5b in mechanotransduction in zebrafish hair cells, showing distinct expression patterns and functional contributions to sensory systems.

Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

This study shows that purinergic signaling in cochlear supporting cells regulates hair cell excitability by altering extracellular space volume through K+ dynamics.

Active outer hair cell motility can suppress vibrations in the organ of Corti

This study shows outer hair cells can either amplify or suppress vibrations in the organ of Corti, affecting cochlear frequency tuning.

Slc26a9P2ACre, a new CRE driver to regulate gene expression in the otic placode lineage and other FGFR2b-dependent epithelia

The paper introduces a new pan-otic CRE driver, Slc26a9P2ACre, which shows reduced brain activity and is used to study FGF signaling and hearing loss.

Single cell and single nucleus RNA-Seq reveal cellular heterogeneity and homeostatic regulatory networks in adult mouse stria vascularis

The paper uses single cell and single nucleus RNA-sequencing to identify cell populations and gene regulatory networks in adult mouse stria vascularis, linking known deafness genes to specific cell types.

L-type voltage-gated calcium channel agonists improve hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher Syndrome Type 1

The paper identifies differences in hair cell biology and behavior in zebrafish myo7aa-/- mutants and shows that L-type voltage-gated calcium channel agonists can rescue these phenotypes.

Phantom auditory perception (tinnitus) is characterised by stronger anticipatory auditory predictions

The paper investigates how tinnitus arises by examining anticipatory auditory predictions in individuals with and without tinnitus using MEG data.

Mechanisms of high-intensity sound exposure on inhibiting hippocampal long-term potentiation: role of brain-derived neurotrophic factor

This study investigates how high-intensity sound exposure inhibits hippocampal long-term potentiation (LTP) by reducing brain-derived neurotrophic factor (BDNF) levels and shows that BDNF or TrkB agonists can reverse this effect.

Synaptic mitochondria are critical for hair-cell synapse formation and function

The paper shows that mitochondrial calcium uptake in zebrafish hair cells is essential for synapse formation and function, linking presynaptic calcium influx to ribbon formation through redox regulation.

Classification of Neurons in the Adult Mouse Cochlear Nucleus: Linear Discriminant Analysis

This study uses linear discriminant analysis to classify neurons in the adult mouse cochlear nucleus based on electrical properties and morphology, revealing distinct clusters of VCN and DCN neurons.