Hydrogels: synthesis, properties, applications

This study uses sulfated hydrogels to show that ECM sulfation enhances tumor cell survival and reduces chemotherapeutic efficacy by modulating stress responses and drug efflux.

This study develops a hyaluronic acid-alginate hydrogel modified with ECM-derived peptides to support the generation and maturation of V2a interneurons for CNS tissue repair.

This study shows that alginate hydrogel stiffness and stress relaxation rates control the release of matrix-bound nanovesicles (MBVs) over time, offering a method to improve their therapeutic delivery.

This paper introduces coagulative granular hydrogels stabilized by enzyme-catalyzed fibrin networks to enhance mechanical integrity and support tissue regeneration.

This paper develops a composite hydrogel (C-gel) that enables localized in situ gelation and sustained nanocarrier release in the anterior chamber of the eye, showing 90% polymer retention and over a month of sustained release in mice.

This paper introduces a nitric oxide-releasing hydrogel catheter lock that prevents bacterial contamination and improves hemocompatibility.

This study characterizes hydrogel viscoelasticity at micro- and macro-scales using AFM and finite element modeling, developing a model with <5% error for parameter prediction.

The paper introduces an accessible platform to measure oxygen diffusion in cell-laden hydrogels and applies it to alginate-immobilized pancreatic beta cells, showing reduced diffusion coefficients with higher gel concentration.

This paper shows that varying hyaluronic acid molecular weight in collagen-HA hydrogels can direct macrophage polarization, but chemical crosslinking of HA prevents this effect.

This study modifies gelatin hydrogels through amination and thiolation to improve mechanical properties of stratified biomaterials for tissue engineering.

This paper develops a degradable hydrogel for in vivo tumor modeling that supports vascularization and immune cell therapy testing in mice.

This paper develops and optimizes peptide crosslinks for hydrogels that are specifically degraded by membrane-type proteases, improving cell behavior compared to existing crosslinks.

This study shows that norbornene homopolymerization limits cell spreading in thiol-ene hydrogels, and reducing norbornene density improves hydrogel relaxation and cell morphology.

This study shows that a synthetic hydrogel enables crypt formation in intestinal organoids without exogenous laminin, revealing insights into mechanical and matricellular signaling.

This study shows that high-viscosity hydrogels lead to increased nascent extracellular matrix deposition by cells, independent of intracellular contractility.

This paper introduces a modular microfluidic system to create stiffness gradient hydrogels with complex profiles, showing their effectiveness in modulating cell behavior.

This paper develops core/shell microgels for in situ cartilage tissue engineering, enabling immediate implantation and spontaneous fusion of cell condensates without prior in vitro culture.

This study shows that nanofibrillar cellulose hydrogels preserve T cell function better than Matrigel or basement membrane extract in 3D cultures.

This paper shows that anisotropic hydrogel degradation patterns enhance hMSC alignment, mechanotransduction, and osteogenic differentiation compared to uniform materials.

This study systematically evaluates how different photoinitiators affect the physicochemical and biological properties of GelMA hydrogels, identifying optimal conditions for various biomedical applications.

This paper quantifies the rheological behavior of granular hydrogels using the Kamani-Donley-Rogers model with Brittility, showing they behave as brittle yield stress fluids with complex transient properties.

This study demonstrates the use of GelMA hydrogels for 3D cell culture with in situ genetic manipulation and spatially controlled gene expression.

This paper demonstrates a method to release probiotics from hydrogels using mechanical fracture, enabling sustained and controllable release of metabolically active microbes.

This paper introduces a light-sensitive hyaluronic acid hydrogel for 3D cell culturing, differentiation, and harvesting of mesenchymal stromal cells, showing it can modulate cell behavior through light exposure.

This study shows that hydrogel-embedded precision-cut lung slices can maintain premalignant lung lesions for six weeks and respond to a cancer prevention agent.

This paper develops a hydrogel platform for subcutaneous delivery of trastuzumab, achieving sustained release over 3 days in vitro and in vivo.

This paper engineers affibodies with tunable affinities for VEGF and PDGF using computational design and yeast display to improve controlled protein release from hydrogels.

This study evaluates AG-based hydrogels for expanding human salivary gland spheroids, finding AGHA gels support larger, viable, and functionally active spheroids with sustained protein expression.

This paper demonstrates that XCSgel, an injectable hydrogel, can localize and release immunotherapeutics to eliminate primary and abscopal murine triple-negative breast tumors with a single injection.