Nerve injury and regeneration

This study identifies rab-27 in C. elegans intestines as a regulator that inhibits axon regeneration through a neuropeptide secretion pathway.

This study shows that inducing collateral sprouting in uninjured sensory neurons in vivo primes them for enhanced axon outgrowth in vitro without axonal injury.

The paper identifies ERK1/2 and other pathways as novel components of Nogo-A signaling that mediate long-term neurite outgrowth inhibition.

The paper identifies novel transcription factor synergies that enhance axon growth by analyzing co-occupancy patterns and validating them through experimental screens and animal models.

This study investigates the role of integrin-linked kinase (ILK) in Nogo-66-induced inhibition of neurite outgrowth, showing ILK regulates downstream signaling and promotes neurite growth.

This study identifies FL2 as a negative regulator of axonal growth and shows that targeting it with siRNA promotes nerve regeneration in a rodent model of peripheral nerve injury.

This study shows that Protrudin, when overexpressed, supports axon regeneration in the adult central nervous system by acting as a scaffold to organize endoplasmic reticulum, integrins, and Rab11 endosomes in the distal axon.

This study shows UNC-16/JIP3 inhibits axonal regeneration by regulating DLK-1 function, affecting actin and microtubule dynamics differently depending on DLK-1 involvement.

This study identifies complexin1 as a key mediator of electroacupuncture's effects on axon regeneration and synaptic plasticity after sciatic nerve injury.

This study identifies ZIP-5/bZIP transcription factor regulation of folate metabolism as critical for aging axon regeneration, showing dietary folic acid improves regeneration in C. elegans and zebrafish.

The paper identifies ADCYAP1 (PACAP) as a key molecule enhancing sensory neuron outgrowth in human nerve regeneration using carpal tunnel syndrome as a model.

The paper uses single-cell multi-omics to show DNA methylation changes in DRG neurons correlate with age and injury responses, particularly in Notch signaling and regeneration-associated genes.

This paper demonstrates that combining KLF6 gene therapy with neural progenitor cell grafts can restore corticospinal tract function after spinal injury in mice.

This study examines how 7,8-dihydroxycoumarin affects myelin morphology and PSD-95 protein levels in mice with sciatic nerve injury, showing dose-dependent effects on nerve recovery.

This study demonstrates that delayed transplantation of olfactory ensheathing cells into a corticospinal tract lesion in rats can restore ipsilateral forepaw function.

The paper uses intravital imaging to show that injured cortical axons undergo a rapid-onset form of Wallerian degeneration (ROWD) that differs from classic Wallerian degeneration in onset timing, speed, and dependency on synaptic density.

This study identifies RAB-5 as a regulator of axonal fusion in C. elegans by controlling EFF-1 endocytosis, showing that perturbing RAB-5 enhances fusion capacity.

This study shows that activating integrins and using BDNF together can promote axon regeneration in the spinal cord by overcoming inhibitory factors like MAG.

This study identifies APL-1 as an inhibitor of axon regeneration in C. elegans motor neurons, showing it acts through the E2 domain and interacts with Rab6/RAB-6.2.

The paper uses imaging to show astrocytes are the main recipients of neuronally released BDNF, with TrkB levels and neuronal activity influencing uptake and physiological effects.

This study shows that genetic background affects optic nerve regeneration, with BXD strains showing significant variation in axonal regrowth.