Nerve injury and regeneration

Discovery of a sulfotyrosine-motif in the human TrkB extracellular domain required for agonist activation

The paper investigates how ZEB85 activates TrkB by identifying a sulfotyrosine motif essential for agonist activation, while BDNF uses a different binding site.

GPNMB enables lysosomal adaptation required for myelin clearance and nerve regeneration after peripheral nerve injury

This study identifies GPNMB as a critical regulator of lysosomal function in macrophages, essential for myelin clearance and nerve regeneration after peripheral nerve injury.

Brain-derived neurotrophic factor (BDNF), estrogen receptors, and mossy cells

The paper investigates BDNF expression and estrogen receptor presence in mossy cells of the dentate gyrus, finding estrous cycle-dependent BDNF levels and high ER expression in MCs.

Outgrowth of Mouse Sensory Neurons is not Mediated by Regeneration Associated Genes in Early Postnatal Stages

This study shows that early postnatal sensory neurons regenerate without upregulating regeneration-associated genes, suggesting distinct regenerative mechanisms compared to adult neurons.

Palmitoylation of p75 neurotrophin receptor is required for retrograde regressive signaling

This study shows that palmitoylation of p75NTR at C281 is essential for retrograde signaling by enabling the formation of p75ICD-positive endosomes for axonal transport and apoptosis.

Huntingtin and Celsr3 Orchestrate Spontaneous Long-Distance Spinal Cord Regeneration

This study identifies celsr3 and huntingtin as critical for long-range spinal cord regeneration in zebrafish, showing distinct roles in initiating and sustaining axonal growth.

BDNF and glucocorticoids modulate neuroplasticity via direct interaction between TRKB and glucocorticoid receptors

This study investigates how glucocorticoids and TRKB signaling interact to modulate neuronal plasticity, finding that glucocorticoids promote TRKB dimerization and interact with TRKB to influence its activity and behavioral effects.

Generation and application of human pluripotent stem cells derived peri-nervoids

This study generates human pluripotent stem cell-derived Schwann cells and neural organoids to create a nerve-like construct, showing improved regeneration in mouse models.

A Reproducible Protocol for Embryonic Chicken Dorsal Root Ganglion Explant Culture and Quantitative Neurite Outgrowth Analysis

The paper describes a protocol for culturing embryonic chicken dorsal root ganglion explants and quantitatively analyzing neurite outgrowth using phase-contrast imaging and image-based tracing.

Spared corticospinal neurons activate an endogenous plasticity program after partial CNS injury

The paper identifies a pro-plasticity program in spared corticospinal neurons after partial CNS injury and validates strategies to enhance neurite regeneration.

Quantification of compensatory motor neuron sprouting at the Drosophila larval neuromuscular junction

This paper describes a protocol to quantify compensatory motor neuron sprouting at the Drosophila larval neuromuscular junction following injury.

Olfactory Mucosa-Derived Mesenchymal Stem Cells Differentiate Towards a Schwann Cell-Like Phenotype Towards Sourcing for Peripheral Nerve Regeneration

This study differentiates olfactory mucosa-derived mesenchymal stem cells into Schwann cell-like cells using conditioned media and growth factors, showing changes in morphology, gene expression, and functionality.

Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences

This study shows that sympathetic aging is reversible and sexually dimorphic, with male mice showing greater denervation due to gonadal influences and target environment changes.

AGC kinase homology requires and enables co-targeting for CNS regeneration

The paper shows co-inhibition of AGC kinases enhances CNS neuron regeneration and identifies TMP-316 as a drug candidate achieving this in a rat model.

Epidermal and ECM Damage Following Pinch Injury Restricts Dendrite Regeneration in Drosophila

This study shows that dendrite regeneration in Drosophila is restricted by damage to surrounding epidermal cells and ECM following pinch injury, unlike laser injury which does not cause such tissue damage.

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis

This study identifies an axon-intrinsic loop where REG3A promotes KHSRP translation, slowing nerve regeneration through localized mRNA synthesis and Ca2+ signaling.

Sex-Dependent Proteomic Remodelling During ex vivo Degeneration of Young and Aged Murine Peripheral Nerves

This study investigates sex-dependent proteomic changes in young and aged mouse peripheral nerves during ex vivo degeneration, revealing sex-specific molecular features of nerve ageing.

In transected nerves, distal repair Schwann cells are required at the injury site to direct and accelerate axonal regrowth

The paper shows that distal Schwann cells at the injury site are essential for guiding and accelerating axonal regrowth after nerve transection in larval zebrafish.

Long-Term Functional and Histological Outcomes Following Sutureless Peripheral Nerve Repair Using Nerve Tape in Pigs

This study compares sutureless Nerve Tape with microsuturing for peripheral nerve repair in pigs, finding improved distal motor recovery with Nerve Tape.

Calcium-dependent cytoskeletal collapse and recovery of axons after partial laser ablation

This study investigates axon cytoskeletal collapse and recovery after partial laser ablation, showing that calcium and mechanical factors regulate retraction and recovery.

Boldine inhibits SARM1 NADase Activity and Preserves Axonal Integrity After Nerve Injury

Combinatorial Control of Corticospinal Axon Growth by Retinoic Acid Receptors

This study identifies RARA and RARG as cooperative regulators of axon regeneration in the CNS and PNS by reactivating developmental growth programs through combinatorial transcriptional control.

Peripheral regeneration of Aβ low-threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways

This study examines Aβ low-threshold mechanoreceptor regeneration after nerve injury, finding incomplete recovery despite activation of regeneration-associated genes.

A sex hormone-BDNF-TrkB axis directs sympathetic innervation in the mouse mammary gland

The paper identifies a sex hormone-BDNF-TrkB signaling pathway that regulates sympathetic innervation in the mouse mammary gland during puberty and pregnancy.

Myosin 5A mediates membrane-associated periodic skeleton reassembly during axon regeneration in response to ROCK-2 inhibition

This study identifies MYO5A as a key mediator of MPS reassembly during axon regeneration, showing that ROCK-2 inhibition enhances regrowth and accelerates MPS recovery.

Endogenous network modeling reveals mechanisms of repair Schwann cell decline and potential recovery targets

The paper constructs an endogenous regulatory network model of Schwann cell dedifferentiation and identifies potential therapeutic targets for nerve repair.

Clinical Relevant Immunosuppressive Drugs Differentially Modulate Axonal Outgrowth from Human Stem Cell Derived Neurons

This study evaluates the effects of immunosuppressive drugs on neurite outgrowth from human neurons and neural progenitor cells, finding that some drugs inhibit axonal regeneration while others do not.

FABP8/PMP2 is a positive regulator of PNS myelination

This study shows that increasing PMP2 in Schwann cells enhances myelin thickness without affecting ultrastructure or nerve function.

Human SHED-derived extracellular cues activate a specialized neuroprotective and regenerative program in developing retinal ganglion cells

This study shows that SHED-derived extracellular factors enhance axonal regeneration and neuronal survival in retinal ganglion cells through distinct paracrine mechanisms.

Single-Cell Atlas of Dorsal Root Ganglion Remodeling After Neuroma-Forming Nerve Injury Reveals Intervention-Specific Glial and Immune Programs

The paper constructs a single-cell atlas of dorsal root ganglion remodeling after nerve injury and compares interventions to identify glial and immune programs associated with pain and regeneration.