Fungal and yeast genetics research

The paper uses DAP-seq to analyze TF binding sites in R. microsporus, revealing DNA methylation's role in gene regulation and expanding fungal motif catalogs.

This study identifies spontaneous inverted triplications (TRP/INVs) in Aspergillus flavus, showing they form in AT-rich centromeric and subtelomeric regions due to palindromic sequences and replication stress.

This study shows that stress-defense factors in yeast regulate the repression of growth-promoting genes, coordinating resource reallocation needed for stress response.

This paper evaluates genetically-encoded reporters in Yarrowia lipolytica, finding that mScarlet-I3 and Nanoluc luciferase provide the highest signal/noise ratios for gene expression studies.

This study shows that HapX, an iron regulator in Aspergillus fumigatus, transitions between states based on iron availability through cluster-binding in conserved cysteine-rich regions, affecting gene expression and iron homeostasis.

The paper designs and validates six minimal integrating shuttle vectors for Saccharomyces cerevisiae with reduced size and restriction sites outside the MCS.

This study identifies mitochondrial efficiency as the key factor determining the Crabtree effect in yeasts by comparing Pichia kluyveri and Saccharomyces cerevisiae.

The paper links genome to proteome in yeast progeny to identify variants controlling proteome diversity and predict their fitness effects under stress.

The paper identifies a yeast survival mechanism called VRQT, where aged stationary-phase cells divide synchronously to enhance population survivorship during starvation.

The paper defines domain boundaries of K1-like killer toxins across yeast species and identifies conserved alpha domains with cytotoxic activity.

The paper shows that deleting BAP2 is lethal in a leucine-requiring yeast strain with fermentable sugars but not other carbon sources, and this lethality is overcome by deleting BUL1.

This study examines how stress conditions alter the structure and function of membrane-based organelles in budding yeast using fluorescent markers.

This study examines how temperature affects meiotic success and recombination rates in two yeast species with different thermal tolerances, finding temperature-dependent differences in sporulation and recombination.

The paper shows that Pho85, a non-canonical CDK, initiates a pathway to restart the cell cycle after stress by phosphorylating Sch9 and Whi5, enabling cell survival.

The paper identifies yeast strains with enhanced recombinant laccase production and characterizes genetic factors contributing to this trait.

This study shows that the yeast Rho5 GTPase's oxidative stress response depends on its proper spatiotemporal distribution, mediated by its dimeric GEF's localization and activity.

This paper uses machine learning to analyze transcriptomic data from Yarrowia lipolytica under various industrial stresses, identifying regulatory modules and their responses to environmental changes.

This paper introduces synthetic tools for engineering multicellularity in yeast by enabling contact-dependent signaling and adhesion, allowing for the creation of multicellular logic circuits and protein interaction sensors.

This paper isolates two fungal strains from geothermal fluids, showing a complex interaction where one strain switches cell morphology in response to the presence of the other.

This paper identifies toxic agar batches that inhibit plating of fission yeast on minimal media and recommends improved quality control measures for agar vendors.

The paper constructs genome-wide conditional degron libraries in yeast to improve functional genomics by enabling controlled protein degradation and avoiding suppressor mutations.

This paper investigates small RNA biogenesis in Aspergillus fumigatus, revealing limited RNAi machinery involvement and identifying tRNA-derived RNAs linked to fungal growth arrest via dsRNA.

The paper develops a yeast biosensor to optimize protein secretion by screening combinations of promoters, signal peptides, and terminators.

The paper improves the functional annotation of the mushroom-forming fungus Coprinopsis cinerea by integrating a chromosome-level genome assembly with extensive expression profiling across multiple conditions.

This study investigates the role of MoLst8 in autophagy and lipid homeostasis in Magnaporthe oryzae, showing its positive regulation of TORC1 and disruption of lipid metabolism in a knockout mutant.

This study uses experimental evolution of S. cerevisiae to identify genetic factors contributing to caffeine tolerance, revealing roles for multidrug resistance and TOR signaling pathways.

This study identifies a genomic region associated with microconidia production in Pyricularia oryzae using GWAS, suggesting potential genes involved in male fertility.

This study shows Cbf11 and Mga2 work together to regulate lipid metabolism and mitotic fidelity in fission yeast, with similar single and double deletion phenotypes.

The paper characterizes TLH gene families in four Fusarium oxysporum strains, identifying conserved motifs, phylogenetic clustering, and subtelomeric regions associated with genome stability.

This study investigates cold adaptation routes in Saccharomyces species by analyzing gene expression and allelic variation across multiple strains.