Migraine and Headache Studies

The neurotrophic factor artemin and its receptor GFRα3 mediate migraine-like pain via the ion channel TRPM8

This study identifies artemin and its receptor GFRα3 as mediators of migraine-like pain via TRPM8 in mice, showing their role in neuroinflammatory processes in the meninges.

Loss of Calcitonin gene-related Related Receptor component protein (RCP) in nervous system can bias gepant antagonism

The paper investigates the effect of RCP loss in a mouse model on CGRP receptor antagonism, finding that olcegepant fails to antagonize CGRP effects in RCP-deficient mice.

Involvement of the cerebellum in structural connectivity enhancement in episodic migraine

This study finds increased structural connectivity in migraine patients, particularly in cerebellar regions, compared to healthy controls using MRI-based connectome analysis.

Resting-State Electroencephalography and Magnetoencephalography in Migraine - A Systematic Review and Meta-Analysis

This study reviews and analyzes resting-state M/EEG data from 27 studies on migraine, finding increased theta power and reduced alpha/beta connectivity in interictal migraineurs.

KCNG4 genetic variant linked to migraine prevents expression of KCNB1

The paper investigates a genetic variant of KCNG4 linked to migraine and shows it prevents KCNB1 expression, suggesting a mechanism involving Kv2.1 currents in the trigeminal system.

Potential Causal Relationship between Faster Walking Pace and Reduced Migraine Risk: A Mendelian Randomization Study

This study uses Mendelian randomization to show that faster walking pace is causally linked to reduced migraine risk.

Spreading depolarization causes reversible neuronal mitochondria fragmentation and swelling in healthy, normally perfused neocortex.

This study shows that spreading depolarization in healthy mice causes reversible mitochondrial fragmentation and swelling in dendrites, which may affect mitochondrial function during migraine aura.

The Effect of P2X7 Antagonism on Subcortical Spread of Optogenetically-Triggered Cortical Spreading Depression and Neuroinflammation

This study investigates the role of P2X7 receptors in subcortical spread of cortical spreading depression and neuroinflammation, finding that P2X7 antagonism prevents neuroinflammation and hypothalamic neuronal activation.

A Longitudinal Exploration of CACNA1A-related Hemiplegic Migraine in Children

This study examines the longitudinal course of CACNA1A-related hemiplegic migraine in children, finding unpredictable severity and timing of events with no clear correlation with epilepsy.

A Novel Hypothesis for Migraine Disease Mechanism: The Creation of a New Attractor Responsible for Migraine Disease Symptoms

This paper proposes a complex system model of the brain as a dynamic system with chaotic attractors to explain migraine disease mechanisms and symptom triggers.

Sexually dimorphic effects of Amylin 1 receptor activation in trigeminovascular neurons

This study investigates how AMY1 receptor activation affects trigeminovascular neurons in female rats during different estrous cycle phases and compares it to males, finding sex-specific effects linked to estrogen levels.

Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonism Reduces Motion Sickness Indicators in Mouse Migraine Models

This study shows that CGRP receptor antagonists reduce motion-induced nausea in mouse migraine models, while triptans are ineffective.

Repetitive Spreading Depolarization induces the activation of cell differentiation, synaptic plasticity and neuroprotective pathways.

This study identifies gene expression changes in brain tissue following spreading depolarization, showing activation of pathways related to cell differentiation, synaptic plasticity, and neuroprotection.

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

This study investigates how meningeal afferents respond to locomotion-related deformations in a migraine model, finding that CSD enhances sensitivity to these deformations.

Increased presynaptic excitability in a migraine with aura mutation

This paper investigates a migraine with aura mutation and finds it increases presynaptic excitability through enhanced glutamatergic synaptic transmission, leading to increased spreading depolarization susceptibility.

P2X7 signaling mediates migraine-related augmentation of meningeal afferent mechanosensitivity

This study shows that P2X7 and Pannexin 1 signaling in meninges mediates mechanical sensitization of afferents after CSD, contributing to migraine headache.

Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders

The paper identifies rare GPR37L1 variants associated with anxiety and migraine using computational analysis and functional experiments in cells and mice.

Both systemic Calcitonin Gene Related Peptide (CGRP) and a vestibular challenge promote anxiety-related behaviors and dynamic imbalance in mice

This study shows that systemic CGRP and vestibular stimulation increase anxiety and imbalance in mice, with stronger effects in females and on specific balance challenges.

Visual Processing During the Interictal Period Between Migraines: A Meta-Analysis

This meta-analysis examines visual function in migraineurs during the interictal period, finding reduced VEP amplitudes and habituation in the P100 component, but no difference between those with and without aura.

Study of association of migraine susceptibility genes with common migraine in 200,000 exome-sequenced UK Biobank participants

This study investigates the association of ten genes linked to migraine in rare syndromes with common migraine in 200,000 UK Biobank participants and finds no significant associations.

Investigation on How Dynamic Effective Connectivity Patterns Encode the Fluctuating Pain Intensity in Chronic Migraine

This study investigates how dynamic effective connectivity patterns in EEG data relate to fluctuating pain intensity in chronic migraine patients using Bayesian models.

Meta-analysis of the effects of clinically-effective therapeutics in the preclinical migraine model as a tool for design optimisation.

This study performs a meta-analysis of anti-migraine drug effects in a preclinical model to improve experimental design and reduce bias.

Multiscale computer modeling of spreading depolarization in brain slices

The paper develops a multiscale computer model of spreading depolarization in brain slices, showing that SD speed depends on tissue properties and is exacerbated by hypoxia and slice thickness.

Three Dimensions of Association Link Migraine Symptoms and Functional Connectivity

The paper identifies three dimensions linking migraine symptoms to brain functional connectivity using CCA and RSFC, revealing novel network targets and patient subtypes.

Validating a computational framework for ionicelectrodiffusion with cortical spreading depression as a case study

The paper validates a computational framework for modelling ion electrodiffusion during cortical spreading depression using experimental comparisons.

Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles

This GWAS identifies 123 migraine risk loci, including subtype-specific variants and novel targets, supporting neurovascular mechanisms in migraine.

CGRP Administration into the Cerebellum Evokes Migraine-like Behaviors Predominately in Female Mice

This study shows that CGRP injection into the cerebellar medial nuclei induces migraine-like behaviors in mice, with female mice showing additional anxiety, tactile hypersensitivity, and pain responses.

Intrinsic Network Connectivity Reflects the Cyclic Trajectory of Migraine Attacks

The paper identifies cyclic changes in intrinsic brain networks during the migraine cycle using fMRI, showing connectivity peaks before headaches and drops during attacks.

Rare risk variants associate with epigenetic dysregulation in migraine

The paper identifies rare variants in the ASTN2 locus associated with migraine, independent of GWAS findings, and proposes a role for Polycomb Response Elements in migraine etiology.

Cortical Oscillatory Dysrhythmias in Visual Snow Syndrome: A MEG Study

This study uses MEG to show increased gamma power and reduced alpha-gamma phase-amplitude coupling in primary visual cortex of visual snow syndrome patients, suggesting hyperexcitability and disrupted rhythmic activity.