Migraine and Headache Studies

PACAP-PAC1 Receptor Inhibition is Effective in Models of Opioid-Induced Medication Overuse Headache

This study shows that inhibiting PACAP-PAC1 receptors reduces opioid-induced chronic headache in mouse models by blocking PACAPergic mechanisms.

Methods for recording and imaging spreading depolarizations and seizure-like events in mouse hippocampal slices

This paper develops an in vitro method to record and image spreading depolarizations and seizure-like events in mouse hippocampal slices without focal stimulation.

Sex differences in migraine: A twin study

This study investigates sex differences in migraine prevalence using twin data, finding that genetic factors alone do not fully explain the sex difference, but prenatal hormone environments may contribute.

Increased Functional Connectivity Characterises the Prodromal Phase of the Migraine Cycle

The paper examines functional connectivity changes across the migraine cycle, finding increased connectivity in the prodromal phase and its collapse during headache, suggesting a mechanism for normalizing cortical processing.

A meta-analysis of the genome-wide association studies on two genetically correlated phenotypes (self-reported headache and self-reported migraine) identifies four new risk loci for headaches (N=397,385)

This study performs a meta-analysis of GWAS on self-reported headache and migraine, identifying four new risk loci for headaches using 397,385 samples.

GABAergic neurons and Nav1.1 channel hyperactivity: a novel neocortex-specific mechanism of cortical spreading depression.

This study identifies a neocortex-specific mechanism of cortical spreading depression (CSD) initiated by hyperactivity of GABAergic neurons and NaV1.1 channel gain-of-function, linking it to Familial Hemiplegic Migraine type-3.

Enhanced reflexive eye closure is mediated by ipRGC signals and is specific to migraine with visual aura

The paper assesses the role of ipRGCs and cones in reflexive eye closure as a measure of photophobia in migraine, finding enhanced responses in MwA compared to other groups.

Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

This study identifies the MrgprB2/MrgprX2 receptor axis as a key regulator of alcohol withdrawal-induced headache through mast cell degranulation and CRF signaling.

Interneuronal dynamics facilitate the initiation of cortical spreading depression

This study shows that inhibitory interneurons influence the initiation of cortical spreading depression by affecting pyramidal cell spike block through dynamic ion concentration changes.

Changes in the gene expression profile during spontaneous migraine attacks

The paper investigates gene expression changes during spontaneous migraine attacks and identifies differentially expressed genes and pathways associated with migraine pathophysiology.

Neuronal complexity is attenuated in chronic migraine and restored by HDAC6 inhibition

This study shows HDAC6 inhibition restores neuronal complexity in chronic migraine models, suggesting it as a potential therapeutic target.

PACAP induces light aversion in mice by an inheritable mechanism independent of CGRP

This study shows PACAP induces light aversion in mice independently of CGRP, with inheritable responder and nonresponder phenotypes and distinct gene expression patterns.

Kcnq2/Kv7.2 controls the threshold and bihemispheric symmetry of cortical spreading depolarization

This study identifies Kcnq2/Kv7.2 as a gene modulating spreading depolarization threshold and bilateral symmetry, with implications for epilepsy and migraine.

Migraine Attacks as a Result of Hypothalamic Loss of Control

This study investigates brain activity changes during migraine cycles, finding cyclic perfusion in the limbic circuit and hypothalamic connectivity shifts, suggesting the hypothalamus drives migraine attacks by losing control over the limbic system.

Parabrachial complex processes dura inputs through a direct trigeminal ganglion-to-parabrachial connection

The paper identifies a direct trigeminal ganglion-to-parabrachial connection that processes dura inputs, suggesting a role in migraine pathogenesis.

Non-canonical glutamate signaling in a genetic model of migraine with aura

The paper identifies non-canonical glutamate signaling in a migraine model, linking it to spreading depolarizations and potential therapeutic targets.

Spreading depressions and periinfarct spreading depolarizations in the context of cortical plasticity

This study investigates whether spreading depolarizations (SDs) and periinfarct depolarizations (PiDs) impair cortical experience-dependent plasticity (ExDP) similarly to stroke, finding no direct causal link between SDs/PiDs and metaplasticity changes.

Adenosine modulates extracellular glutamate levels via adenosine A2A receptors in the delayed-ethanol induced headache.

This study shows that acetate increases brainstem adenosine and glutamate, contributing to ethanol-induced headache via A2A receptor activation.

Auditory attention alterations in migraine: a behavioral and MEG/EEG study

This study investigates attentional alterations in migraine using behavioral and MEG/EEG data, finding increased bottom-up orienting responses and enhanced top-down attention recruitment in migraineurs.

Selective amplification of ipRGC signals accounts for interictal photophobia in migraine

This study investigates how melanopsin and cone signals contribute to photophobia in migraine and finds that migraineurs amplify ipRGC signals specifically for discomfort, not pupil responses.

The role of the meningeal lymphatic system in local inflammation and trigeminal nociception implicated in migraine pain

This study investigates the role of the meningeal lymphatic system in migraine pain by analyzing inflammatory and nociceptive responses in mice lacking this system.

GABA AND GLUTAMATE CHANGES IN PEDIATRIC MIGRAINE

This study measures GABA and glutamate levels in children with migraine using MRS, finding lower glutamate in the visual cortex and associations between metabolite levels and migraine characteristics.

Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury

This study investigates sex differences in post-traumatic headache-like behaviors and treatment responses in female rats after mild closed head injury, finding prolonged hyperalgesia and reduced effectiveness of anti-CGRP treatment in females.

Regulation of CSF and brain tissue sodium levels by the blood-CSF and blood-brain barriers during migraine

The paper develops a mechanistic model of sodium transport across the blood-CSF and blood-brain barriers in rats to investigate their roles in migraine-associated sodium dysregulation.

Differences in Early and Late Pattern-Onset Visual-Evoked Potentials between Self-Reported Migraineurs and Controls

The paper compares visual evoked potentials in migraineurs and controls to investigate cortical hyperexcitation and feedback mechanisms related to visual discomfort.

Functional magnetic resonance imaging of regional impaired cerebrovascular reactivity for migraineurs in the interictal state

The paper maps cerebrovascular reactivity impairment in episodic migraineurs using fMRI and MRA, finding reduced BOLD responses in MOA patients at the red nucleus.

A mathematical model of mitochondrial calcium-phosphate dissolution as a mechanism for persistent post-CSD vasoconstriction

The paper develops a mathematical model showing mitochondrial calcium-phosphate dissolution drives prolonged vasoconstriction after cortical spreading depolarization.

Relating excitatory and inhibitory neurochemicals to visual perception: a magnetic resonance study of occipital cortex between migraine events.

This study examines the relationship between neurochemical levels (GABA and Glx) in the occipital cortex and binocular rivalry percept duration in migraineurs and controls, finding no significant correlation.

TRESK K+ Channel Activity Regulates Trigeminal Nociception and Headache

This study shows that TRESK K+ channel activity is required for trigeminal pain regulation, with loss of TRESK increasing headache-like behaviors in mice.

Intact mast cell content during mild head injury is required for the development of latent pain sensitization - implications for mechanisms underlying post-traumatic headache

This study shows that intact mast cells are required for latent pain sensitization after mild head injury, suggesting potential therapeutic targets for post-traumatic headache.