Migraine and Headache Studies

Computer models predict differential dendritic vulnerability with ischemia and spreading depression

The paper uses computer models to predict differential dendritic vulnerability to ischemia and spreading depression, finding greater calcium accumulation in basilar dendrites and higher intracellular chloride in distal apical dendrites during ischemia.

PN6047 Demonstrates Broad Preclinical Efficacy in Headache Models as a Novel Delta-Opioid Receptor Agonist

This paper evaluates the efficacy of PN6047, a novel DOR agonist, in preclinical headache models and finds it effectively reduces pain and prevents medication overuse headache.

An astro-neural-field model with application to cortical spreading depolarization

The paper introduces an astro-neural-field model to study cortical spreading depolarization, showing improved fit to experimental data and new insights into its mechanisms.

Early Life Stress induces brain-wide electrical network predisposition to migraine

This study shows early life stress increases vulnerability to migraine by altering brain network activity in response to CGRP.

Intravital calcium imaging of meningeal macrophages reveals niche-specific dynamics and aberrant responses to brain hyperexcitability

This study uses intravital imaging to analyze calcium dynamics in meningeal macrophages under homeostasis and during brain hyperexcitability, revealing niche-specific behaviors and signaling responses.

De novo nitric oxide synthesis drives tactile hypersensitivity induced by ATP-sensitive potassium channel opening in mice: Relevance to migraine and other headaches

This study shows that levcromakalim-induced tactile hypersensitivity in mice involves eNOS and peroxynitrite, not classical NO-sGC-cGMP signaling, suggesting nitrosative stress as a therapeutic target for migraine.

Fine-mapping a genome-wide meta-analysis of 98,374 migraine cases identifies 181 sets of candidate causal variants

This study fine-maps genome-wide association study results for migraine, identifying 181 credible sets of candidate causal variants across 102 regions.

Pharmacological inhibition of all known major inward cationic currents does not block the induction of spreading depolarizations

The paper investigates whether blocking major inward cationic currents can prevent spreading depolarizations in zebrafish and mice, finding that these currents are not sufficient to block SD induction.

Cortical astrocyte activation triggers meningeal nociception and migraine-like pain

This study shows that activating astrocytes in the visual cortex of rats triggers meningeal nociception and migraine-like behaviors by increasing nociceptor activity and pain sensitivity.

Headache-specific Hyperexcitation Sensitises and Habituates on different Time Scales: An Event Related Potential study of Pattern-Glare

The paper examines ERP responses to pattern-glare stimuli in a healthy population, finding hyperexcitability in the visual cortex linked to migraine susceptibility and differing habituation/sensitization dynamics.

Cold Receptor TRPM8 as a target for Migraine-associated Pain and Affective Comorbidities

This study investigates the role of TRPM8 in migraine and affective comorbidities using mouse models and human iPSC-derived neurons, finding that TRPM8 modulation can alleviate pain but not depression.

GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model

This study investigates the role of GABAergic neurons in cortical spreading depolarization (CSD) propagation using experiments and a novel neural field model, finding that reduced GABAergic synaptic transmission enhances CSD propagation.

Systemic Calcitonin Gene-Related Peptide (CGRP) modifies auditory and vestibular end organ electrical potentials, and increases sensory hypersensitivities

This study shows that systemic CGRP modulates inner ear potentials and induces migraine-like behaviors in mice, suggesting a direct role for CGRP in auditory and vestibular hypersensitivities.

Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity

This study shows that overexpressing human RAMP1 in mice increases CGRP signaling and makes them resistant to migraine treatments like olcegepant and rizatriptan.

The neurotrophic factor artemin and its receptor GFRα3 mediate migraine-like pain via the ion channel TRPM8

This study identifies artemin and its receptor GFRα3 as mediators of migraine-like pain via TRPM8 in mice, showing their role in neuroinflammatory processes in the meninges.

Involvement of the cerebellum in structural connectivity enhancement in episodic migraine

This study finds increased structural connectivity in migraine patients, particularly in cerebellar regions, compared to healthy controls using MRI-based connectome analysis.

Resting-State Electroencephalography and Magnetoencephalography in Migraine - A Systematic Review and Meta-Analysis

This study reviews and analyzes resting-state M/EEG data from 27 studies on migraine, finding increased theta power and reduced alpha/beta connectivity in interictal migraineurs.

KCNG4 genetic variant linked to migraine prevents expression of KCNB1

The paper investigates a genetic variant of KCNG4 linked to migraine and shows it prevents KCNB1 expression, suggesting a mechanism involving Kv2.1 currents in the trigeminal system.

Spreading depolarization causes reversible neuronal mitochondria fragmentation and swelling in healthy, normally perfused neocortex.

This study shows that spreading depolarization in healthy mice causes reversible mitochondrial fragmentation and swelling in dendrites, which may affect mitochondrial function during migraine aura.

The Effect of P2X7 Antagonism on Subcortical Spread of Optogenetically-Triggered Cortical Spreading Depression and Neuroinflammation

This study investigates the role of P2X7 receptors in subcortical spread of cortical spreading depression and neuroinflammation, finding that P2X7 antagonism prevents neuroinflammation and hypothalamic neuronal activation.

A Novel Hypothesis for Migraine Disease Mechanism: The Creation of a New Attractor Responsible for Migraine Disease Symptoms

This paper proposes a complex system model of the brain as a dynamic system with chaotic attractors to explain migraine disease mechanisms and symptom triggers.

Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonism Reduces Motion Sickness Indicators in Mouse Migraine Models

This study shows that CGRP receptor antagonists reduce motion-induced nausea in mouse migraine models, while triptans are ineffective.

Repetitive Spreading Depolarization induces the activation of cell differentiation, synaptic plasticity and neuroprotective pathways.

This study identifies gene expression changes in brain tissue following spreading depolarization, showing activation of pathways related to cell differentiation, synaptic plasticity, and neuroprotection.

Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

This study investigates how meningeal afferents respond to locomotion-related deformations in a migraine model, finding that CSD enhances sensitivity to these deformations.

Increased presynaptic excitability in a migraine with aura mutation

This paper investigates a migraine with aura mutation and finds it increases presynaptic excitability through enhanced glutamatergic synaptic transmission, leading to increased spreading depolarization susceptibility.

P2X7 signaling mediates migraine-related augmentation of meningeal afferent mechanosensitivity

This study shows that P2X7 and Pannexin 1 signaling in meninges mediates mechanical sensitization of afferents after CSD, contributing to migraine headache.

Visual Processing During the Interictal Period Between Migraines: A Meta-Analysis

This meta-analysis examines visual function in migraineurs during the interictal period, finding reduced VEP amplitudes and habituation in the P100 component, but no difference between those with and without aura.

Study of association of migraine susceptibility genes with common migraine in 200,000 exome-sequenced UK Biobank participants

This study investigates the association of ten genes linked to migraine in rare syndromes with common migraine in 200,000 UK Biobank participants and finds no significant associations.

Investigation on How Dynamic Effective Connectivity Patterns Encode the Fluctuating Pain Intensity in Chronic Migraine

This study investigates how dynamic effective connectivity patterns in EEG data relate to fluctuating pain intensity in chronic migraine patients using Bayesian models.

Multiscale computer modeling of spreading depolarization in brain slices

The paper develops a multiscale computer model of spreading depolarization in brain slices, showing that SD speed depends on tissue properties and is exacerbated by hypoxia and slice thickness.