Migraine and Headache Studies

TRPV1-expressing neurons are dispensable for photophobia: evidence from a novel mouse light sensitivity assay

This paper introduces a novel light sensitivity assay to study photophobia in mice and shows TRPV1-expressing neurons are not required for light hypersensitivity induced by migraine triggers.

Genomic Architecture of Migraine: A Multi ancestry GWAS Meta analysis of 2.5 Million Participants

This study conducts a multi-ancestry GWAS meta-analysis of 2.5 million participants to identify genetic variants associated with migraine and link them to biological pathways and therapeutic targets.

Continuous sumatriptan exposure induces persistent trigeminovascular sensitisation and brain perfusion changes in a rat model of medication overuse headache.

This study shows that continuous sumatriptan exposure in rats causes reversible allodynia and persistent trigeminovascular sensitisation and reduced brain perfusion.

Mesoscale Functional Reorganization of Cortical Networks After Cortical Spreading Depression

This study examines how cortical spreading depression (CSD) alters resting-state functional connectivity and network topology in mice, showing time-dependent changes reversed by naproxen and medication effects on connectivity.

Triptans reprogram Schwann cells to drive medication-overuse headache via β-glycan/TGF-β3 signaling

This study identifies Schwann cell 5-HT1B/D signaling as a dual mediator of triptan efficacy and medication-overuse headache via TGF-β3-driven proalgesic pathways.

Glymphatic function restored by α1-noradrenergic antagonism alleviates headache allodynia in mice

This study shows that prazosin, an α1-noradrenergic antagonist, restores glymphatic function and reduces facial allodynia in mice with migraine-like symptoms.

Neuropeptide S as a potential risk locus for migraine in the Portuguese population

The paper conducts a GWAS in the Portuguese population to identify migraine risk loci, finding a novel association with the NPS gene and highlighting potential therapeutic targets.

Whole brain fluorescence imaging in Drosophila reveals spreading depression and its initiation, propagation, and resilience dynamics.

This study uses whole-brain fluorescence imaging in Drosophila to observe spreading depression, showing it initiates at multiple sites and is followed by a refractory period that increases susceptibility.

Olfactory Bulb Pinprick Induction of Cortical Spreading Depolarizations

This study introduces a non-invasive method to induce cortical spreading depolarizations in rodents using olfactory bulb pinprick, showing reliable CSD induction without cortical injury.

RNA-seq reveals transcriptomic differences in circadian-related genes of the choroid plexus in a preclinical chronic migraine model.

The paper uses RNA-seq to identify sex-specific circadian gene expression changes in the choroid plexus of a chronic migraine rat model.

Disrupted salience network dynamics during the imagery of migraine attacks

The paper investigates disrupted salience network dynamics in migraine patients during pain imagery, finding shorter lifetime in the network compared to healthy controls during this task.

Daily light exposure habits of youth with migraine: A prospective pilot study

This study measures light exposure in youth with migraine using wearable devices and finds phase shifts in light exposure patterns between chronic and non-chronic migraineurs.

Inhibition of Posterior Thalamic Nuclei Attenuates CGRP-induced Migraine-like Behavior in Mice

This study shows that inhibiting the posterior thalamic nuclei in mice reduces CGRP-induced touch hypersensitivity and partially reduces light aversion, suggesting the PoT's role in migraine-like behaviors.

Investigating the Mechanisms and Potential Therapeutic Targets of Vestibular Migraine

This paper identifies six key genes associated with vestibular migraine using bioinformatics analysis and suggests CABIN1 as a potential diagnostic biomarker.

Disrupted activation of pain networks during attack imagery in patients with episodic migraine

This study uses fMRI to compare brain activation during pain imagery between migraine patients and healthy controls, finding deactivation of pain inhibition networks in migraineurs.

Relationships between migraine and interoception: normal accuracy but altered sensibility and behaviour

This study investigates interoception differences in migraineurs, finding altered behavior and confidence but not accuracy in heartbeat detection tasks.

Loss of Calcitonin gene-related Related Receptor component protein (RCP) in nervous system can bias gepant antagonism

The paper investigates the effect of RCP loss in a mouse model on CGRP receptor antagonism, finding that olcegepant fails to antagonize CGRP effects in RCP-deficient mice.

Potential Causal Relationship between Faster Walking Pace and Reduced Migraine Risk: A Mendelian Randomization Study

This study uses Mendelian randomization to show that faster walking pace is causally linked to reduced migraine risk.

A Longitudinal Exploration of CACNA1A-related Hemiplegic Migraine in Children

This study examines the longitudinal course of CACNA1A-related hemiplegic migraine in children, finding unpredictable severity and timing of events with no clear correlation with epilepsy.

Sexually dimorphic effects of Amylin 1 receptor activation in trigeminovascular neurons

This study investigates how AMY1 receptor activation affects trigeminovascular neurons in female rats during different estrous cycle phases and compares it to males, finding sex-specific effects linked to estrogen levels.

Rare GPR37L1 variants reveal potential roles in anxiety and migraine disorders

The paper identifies rare GPR37L1 variants associated with anxiety and migraine using computational analysis and functional experiments in cells and mice.

Both systemic Calcitonin Gene Related Peptide (CGRP) and a vestibular challenge promote anxiety-related behaviors and dynamic imbalance in mice

This study shows that systemic CGRP and vestibular stimulation increase anxiety and imbalance in mice, with stronger effects in females and on specific balance challenges.

Meta-analysis of the effects of clinically-effective therapeutics in the preclinical migraine model as a tool for design optimisation.

This study performs a meta-analysis of anti-migraine drug effects in a preclinical model to improve experimental design and reduce bias.

CGRP Administration into the Cerebellum Evokes Migraine-like Behaviors Predominately in Female Mice

This study shows that CGRP injection into the cerebellar medial nuclei induces migraine-like behaviors in mice, with female mice showing additional anxiety, tactile hypersensitivity, and pain responses.

Rare risk variants associate with epigenetic dysregulation in migraine

The paper identifies rare variants in the ASTN2 locus associated with migraine, independent of GWAS findings, and proposes a role for Polycomb Response Elements in migraine etiology.

PACAP-PAC1 Receptor Inhibition is Effective in Models of Opioid-Induced Medication Overuse Headache

This study shows that inhibiting PACAP-PAC1 receptors reduces opioid-induced chronic headache in mouse models by blocking PACAPergic mechanisms.

Sex differences in migraine: A twin study

This study investigates sex differences in migraine prevalence using twin data, finding that genetic factors alone do not fully explain the sex difference, but prenatal hormone environments may contribute.

Increased Functional Connectivity Characterises the Prodromal Phase of the Migraine Cycle

The paper examines functional connectivity changes across the migraine cycle, finding increased connectivity in the prodromal phase and its collapse during headache, suggesting a mechanism for normalizing cortical processing.

A meta-analysis of the genome-wide association studies on two genetically correlated phenotypes (self-reported headache and self-reported migraine) identifies four new risk loci for headaches (N=397,385)

This study performs a meta-analysis of GWAS on self-reported headache and migraine, identifying four new risk loci for headaches using 397,385 samples.

Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache

This study identifies the MrgprB2/MrgprX2 receptor axis as a key regulator of alcohol withdrawal-induced headache through mast cell degranulation and CRF signaling.