Stress Responses and Cortisol

The paper identifies the thalamic paraventricular nucleus (PVT) as a region selectively activated by early-life adversity (ELA) in mice, linking it to long-term reward-related behavioral deficits.

The paper examines how loss of ultradian cortisol rhythm affects emotional processing in cortical brain regions by analyzing transcriptional and cell type profiles.

The paper identifies a glucocorticoid-sensitive period in zebrafish corticotroph development and links it to stress-related behaviors.

This study examines rapid volumetric brain changes after acute psychosocial stress using MRI and finds significant group-by-time interactions in grey matter volume and associations with stress measures.

This study investigates how early life stress and re-exposure to stress affect neuronal activity in the lateral habenula of adult mice, finding that hypoactivity and sensitized responses contribute to depressive-like behaviors.

This study identifies transthyretin (TTR) as a key regulator of escalated aggression and its intergenerational inheritance through impaired thyroid hormone availability in the brain.

This study shows that microglia in the locus coeruleus of female rats influence hypervigilant responses to social stress, with site-specific microglia depletion reducing stress-induced behaviors.

This study shows that maternal immune activation during lactation alters milk composition and leads to behavioral and physiological changes in offspring.

The paper demonstrates that hippocampal output to the BNST inhibits the HPA axis by disynaptic inhibition of CRF+ PVN neurons during acute stress.

This study shows that early life stress in zebrafish affects glucocorticoid signaling during a critical developmental window, leading to long-term anxiety-like behavior and cortisol dysregulation.

The paper shows that early-life adversity impairs microglial pruning of excitatory synapses on CRH-expressing hypothalamic neurons, leading to heightened stress responses later in life.

This study examines long-term effects of adolescent alcohol exposure on behavior and neurobiological markers in mice, finding persistent anxiety and changes in GR, CRF, and BDNF expression in limbic brain regions.

The paper characterizes behavioral, physiological, and neuroendocrine profiles of mice before, during, and after chronic social defeat stress, finding that early coping strategies better predict resilience or susceptibility than traditional behavioral read-outs.

This study reviews 39 rodent studies on early-life adversity's effects on immediate-early gene expression, finding that ELA increases cFos expression under specific conditions.

The paper identifies epigenetic changes in neocortical excitatory neurons under chronic stress that contribute to depression-like behaviors in mice.

This study links baseline interleukin-6 plasma levels to neural stress responses in healthy adults, finding negative associations in specific brain regions.

This study uses single-cell RNA sequencing to identify lasting transcriptional changes in hypothalamic CRH-expressing neurons after early-life adversity, linking these changes to long-term stress responses.

This study examines the effects of three water restriction schedules on rodent growth, hydration, and stress hormone levels over 80 days, finding no dehydration but differential stress responses.

The paper investigates transcriptomic changes in cortical microcircuit cell types under chronic stress and finds coordinated shifts in gene expression patterns associated with altered excitation-inhibition balance.

The paper shows that social rank and history of winning influence stress susceptibility in mice, with dominance conferring resilience and subordination increasing susceptibility.

This study shows that chronic adolescent stress increases exploratory behavior and hippocampal gene expression but does not affect acute stress responses in adult mice.

The paper investigates how self-related belief updating helps manage stress-induced negative affect after social-evaluative stress, showing it improves recovery compared to physical stress or no stress.

The paper investigates the cortisol awakening response (CAR) and its role in brain preparedness, finding that CAR predicts improved neural efficiency and working memory performance.

This paper investigates how chronic unpredictable stress affects CRF and glucocorticoid receptors in brain regions related to the HPA axis and finds that stress increases CRF2 and GR levels in specific brain areas.

This study shows that early life stress alters the transcriptome of NG2+ glia, increases Nav channel activity, and impairs cognitive performance in adulthood.

This study investigates sex differences in how the infralimbic prefrontal cortex regulates stress responses and cardiovascular outcomes in rodents.

This study examines how chronic mild unpredictable stress affects astrocyte density and morphology in different hippocampal subfields in mice, finding differential effects across subpopulations.

This study shows that juvenile stress alters grey matter myelination in adult female rats but not males, highlighting sex-specific vulnerability during peri-adolescence.