Neurological disorders and treatments

Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation

The paper investigates the role of cerebellar inhibitory neurons in dystonic crisis and shows that modulating these neurons can induce or alleviate the condition in mice.

NeoDBS: Open-Source Platform for Visualization and Analysis of Electrophysiological Recordings from Deep Brain Stimulation Systems

NeoDBS provides an open-source platform for visualizing and analyzing electrophysiological recordings from DBS systems to identify biomarkers for therapy optimization.

Insulotaxy: Navigating the Human Insula with a Novel Stereotactic Framework

This paper introduces a novel stereotactic coordinate system for the insula to improve surgical targeting and outcome assessment by accounting for individual anatomical variability.

Deep brain stimulation reduces subthalamic nucleus pathological dynamics and rescues gait deficits associated with dopamine loss

This study shows that deep brain stimulation reduces pathological STN dynamics and rescues gait deficits in dopamine-depleted Parkinson's mice.

A cardiac pulse signal affects local field potentials recorded from deep brain stimulation electrodes across clinical targets

This study identifies a cardiac pulse signal affecting LFP recordings from DBS electrodes across multiple brain regions and patient groups, introducing an algorithm to detect and extract it.

In silico model of basal ganglia Deep Brain Stimulation in Parkinsons Disease captures range of effective parameters for pathological beta power suppression

The paper develops a computational model of basal ganglia DBS in Parkinson's disease to identify effective parameters for suppressing pathological beta oscillations.

Copy Number Variant Duplications Associated with Essential Tremor

This study identifies rare copy number duplications in protein coding regions as risk factors for essential tremor, but does not reliably identify specific susceptibility genes.

Deep neurobehavioral phenotyping uncovers neural fingerprints of locomotor deficits in Parkinson's disease

This study uses deep neurobehavioral phenotyping to identify neural features associated with gait deficits in Parkinson's disease, revealing biomarkers for potential therapeutic applications.

Ephaptic coupling and power fluctuations in depression

The paper analyzes LFP data from the subcallosal cingulate cortex following DBS implantation to explore neural dynamics and introduces two new measures to assess brain power fluctuations in depression.

Fibroblast transcriptomics in molecular diagnostics of a comprehensive dystonia cohort

The paper uses fibroblast RNA-seq to improve molecular diagnosis in dystonia patients by identifying RNA expression and splicing defects missed by genomic sequencing.

Localizing electrophysiologic cue-reactivity within the nucleus accumbens guides deep brain stimulation for opioid use disorder

The paper uses electrophysiological data from the nucleus accumbens to guide deep brain stimulation for opioid use disorder, showing suppression of drug-related cravings with targeted stimulation.

Distinct roles of the human cuneiform and pedunculopontine nuclei in gait initiation and freezing of gait

This study identifies distinct roles of the cuneiform and pedunculopontine nuclei in gait initiation and freezing of gait in Parkinson's disease using local field potentials and biomechanical markers.

Real-time Bayesian optimization of deep brain stimulation for personalized cognitive control enhancement

This study uses Bayesian Optimization to find optimal DBS parameters in rats for improving cognitive control, showing consistent effects across acute and chronic settings.

Subthalamic nucleus controls cautious action timing under threat

This paper shows that subthalamic nucleus (STN) glutamatergic neurons regulate action timing under threat by modulating response initiation speed and caution.

Inconsistent Subthalamic Beta Expression in the Local Field Potential amid In- and Anti-Phasic Neuronal Bursts.

This study quantifies beta LFP expression in Parkinson's patients and finds it is present in less than half, with implications for DBS guidance and the need for multiple biomarkers.

Developmental, neuroanatomical and cellular expression of genes causing dystonia

The paper examines the expression patterns of dystonia-causing genes across developmental stages and brain regions to identify key areas and cell types for disease modeling and therapy.

Towards individualized deep brain stimulation: A stereoelectroencephalography-based workflow for neurostimulation target identification

This paper develops a statistics-driven workflow using stereoelectroencephalography to identify personalized deep brain stimulation targets through power analysis and effect size calculations.

Distinct Temporal Patterns of Human Neural Firing in the Subthalamic Nucleus During Speech and Orofacial Movement

The paper examines STN neural activity during speech and orofacial movement tasks, finding that 22% of clusters are speech-specific, 12% movement-specific, and 27% respond to both.

Insights into Essential Tremor and Essential Tremor-Plus from Common Variants

This study compares brain maps and polygenic risk scores for Essential Tremor and related phenotypes to assess genetic overlap and diagnostic precision.

Longitudinal Changes in Cortical Response Dynamics with Deep Brain Stimulation to the Subcallosal Cingulate for Treatment-Resistant Depression

This study tracks changes in cortical response dynamics during SCC-DBS for treatment-resistant depression, finding reduced latency and increased magnitude of stimulation-evoked potentials over time.

Electrophysiological Brain Connectivity and Subjective States Evoked by Electrical Stimulation of the Human Mediodorsal Thalamus

This study uses electrical stimulation of the human mediodorsal thalamus to investigate its impact on conscious experience and brain connectivity in epilepsy patients.

Parvalbumin interneurons gate and shape striatal sequences

The paper shows that parvalbumin interneurons restrain and shape striatal firing sequences during action execution in rats.

Beyond beta rhythms: Aperiodic broadband power reflects Parkinson's disease severity - a multicenter study

This study shows that aperiodic broadband power, not just beta oscillations, is linked to Parkinson's disease severity and is increased in the more affected hemisphere.

Deep Brain Stimulation rescues the homeostasis disruption of circulating D- and L-amino acids level in men with Parkinson's Disease

This study shows that Deep Brain Stimulation (STN-DBS) restores circulating D- and L-amino acid levels in male Parkinson's patients, unlike L-DOPA therapy, and suggests these amino acids as potential early biomarkers.

Cingulate-centered flexible control: physiologic correlates and enhancement by internal capsule stimulation

The paper identifies a neural mechanism for flexible cognitive control involving theta-phase coordination in the right anterior cingulate cortex and shows that internal capsule stimulation can enhance this mechanism.

Cerebellar a1D-adrenergic receptors mediate stress-induced dystonia in totteringtg/tg mice

This study identifies cerebellar 1D-adrenergic receptors as key mediators of stress-induced dystonia in EA2 mice, showing their role in NE-mediated neuronal dysfunction.

Selective innervation of subpopulations of striatal neurons by distinct sets of neurons of the external globus pallidus

The paper maps pallidostriatal connectivity in mice, showing distinct innervation patterns of striatal neuron subpopulations by different pallidal neuron types.

Network mechanisms in rapid-onset dystonia-parkinsonism

This study investigates neuronal network activity in a rat model of RDP, showing that specific beta and gamma oscillations in brain regions are associated with dystonia and parkinsonism symptoms.

Change in brain molecular landscapes following electrical stimulation of the nucleus accumbens

This study uses spatial transcriptomics to identify gene expression changes in the mouse brain following nucleus accumbens deep brain stimulation, revealing alterations in synaptic function and neuronal connectivity.

Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson's disease

This study shows that state-dependent deep brain stimulation in Parkinson's disease increases movement speed more effectively during fast movements, using machine learning to decode brain signals for real-time adjustments.