Neurological disorders and treatments

Excitatory drive to the globus pallidus external segment facilitates action initiation in non-human primates

This study investigates the role of the primate globus pallidus external segment in action initiation and suppression using single-unit recordings in macaques, identifying distinct neuronal clusters with facilitatory and inhibitory functions.

Characterization of mice with cell type-specific Gnal loss of function provides insights on GNAL-linked dystonia

This study uses mouse models to investigate the role of Gnal loss in specific striatal projection neurons, revealing distinct effects on motor behavior and drug responses.

Chemogenetic Manipulation of the Subthalamic Nucleus-Substantia Nigra Pars Reticulata Pathway Promotes Recovery in HemiParkinsonian Rat Models

This study shows that chemogenetic manipulation of the subthalamic nucleus-substantia nigra pars reticulata pathway reduces amphetamine-induced rotations in Parkinson's disease models.

Dynamic neural states underpin bradykinesia severity in Parkinsons disease

This study identifies neural states in Parkinson's disease patients using Hidden Markov Models and links them to bradykinesia severity through spectral and temporal features.

Remote magnetomechanical neuromodulation uncovers a novel therapeutic mechanism for alleviating Parkinsonian symptoms in freely moving mice

This paper introduces a wireless magnetomechanical neuromodulation system that alleviates Parkinsonian symptoms in mice by stimulating mechanosensory pathways without implanted electrodes.

Behavioral Signature of Trihexyphenidyl in The Tor1a (DYT1) Knockin Mouse Model of Dystonia

The paper uses MoSeq to analyze behavioral changes in dystonia mouse models after trihexyphenidyl treatment, finding genotype and sex-specific shifts in behavioral structure.

Acute cortical stroke alters neural activity in the subthalamic nucleus, which correlates with motor disability in rats

This study examines how acute cortical stroke affects neural activity in the subthalamic nucleus of rats and links these changes to motor disability.

Closed-loop spinal cord stimulation is superior in restoring locomotion in rodent models of Parkinson's Disease

This study shows that closed-loop spinal cord stimulation (CLDCS) is more effective than traditional methods in restoring locomotion in a Parkinson's disease rodent model by targeting beta oscillations.

Multivariate Associations Between Neurophysiological Activity and Sensory Motor Cortical Morphometry in Parkinson's Disease

This study identifies structure-function relationships in Parkinson's disease by linking cortical morphometry with neurophysiological activity using multimodal data.

Movement-related activity in the internal globus pallidus of the parkinsonian macaque

This study examines how parkinsonism affects movement-related activity in the GPi of macaques, finding altered timing and magnitude of neuronal responses.

Modeling Laryngeal Dystonia through Spectral Analyses of Vocalizations in a Dystonia Mouse Model

The paper shows a dystonia mouse model exhibits vocal-motor deficits similar to laryngeal dystonia, supporting its use for research.

Abnormal hyperactivity of specific striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering

The paper identifies two main dyskinesia types and pathological rotations in a mouse model of LID using high-resolution motion sensors and video recordings, linking them to abnormal activity in specific striatal SPN ensembles.

Cell-type specific responses to single-pulse electrical stimulation of the human brain

This study examines how human neurons respond to single-pulse electrical stimulation, finding that most neurons show firing rate suppression, with differences based on cell type and stimulation distance.

Contribution of glutamatergic projections to neurons in the nonhuman primate lateral substantia nigra pars reticulata for the reactive inhibition

This study investigates how SNr neurons in macaques modulate activity to facilitate and suppress actions, showing that glutamatergic inputs are critical for suppression.

Stimulation modulates cell assemblies linked with gene networks in the human temporal cortex ex vivo

The paper shows that stimulation increases firing rates in pyramidal cells and strengthens cell assemblies in the human temporal cortex, linked to gene networks involving excitatory neurons and non-neurons.

Genetic Diversity and Expanded Phenotypes in Dystonia: Insights from Large-Scale Exome Sequencing

This study uses exome sequencing to identify genetic variants in dystonia patients, finding 137 likely pathogenic variants in 51 genes and expanding the known phenotypic spectrum of dystonia-related genes.

Parameterization of intraoperative human microelectroderecordings: Linking action potential morphology to brainanatomy

The paper introduces a method to parameterize and cluster single-unit action potentials from DBS microelectrode recordings to improve lead placement in deep brain stimulation.

Internal Resonance Dynamics in a Delayed van der Pol Oscillator Modeling Basal Ganglia Oscillations

This paper models Parkinson's disease symptoms using a delayed van der Pol oscillator to show how feedback delays and saturation lead to motor dysfunction and resonance.

Nucleus Basalis of Meynert as a DBS target

This study investigates the effects of different deep brain stimulation patterns on nucleus basalis of Meynert in mice, finding that nested stimulation preserves gamma activity while tonic stimulation suppresses broad-band cortical activity.

Cocaine withdrawal enhances subthalamic reward sensitivity

This study shows that cocaine withdrawal increases reward sensitivity in the subthalamic nucleus, suggesting a potential mechanism for the therapeutic effects of deep brain stimulation in addiction.

Movement execution defines a distinct neural state in dyskinesia and enhances decoding

The paper identifies movement execution as a distinct neural state in Parkinson's dyskinesia, showing it enhances decoding of dyskinesia through specific oscillatory patterns.

Context-Dependent Modulations of Subthalamo-Cortical Synchronization during Rapid Reversals of Movement Direction in Parkinson's Disease

This study examines beta oscillations in Parkinson's disease patients during movement direction reversals, finding context-dependent changes in subthalamo-cortical synchronization and beta power modulations.

Magnetoelectric nanodiscs diminish motor deficits in a model of Parkinson's disease

This study develops magnetoelectric nanodiscs (MENDs) for deep brain stimulation in Parkinson's disease models, showing motor improvements and reduced oxidative stress compared to traditional DBS.

Experimental parkinsonism induced by tetanus toxin injected into basal ganglia

This study injects tetanus toxin into different basal ganglia regions in rats to induce motor dysfunctions resembling parkinsonism, finding region-specific effects and reversible symptoms.

Unilateral damage to the entopeduncular nucleus causes forelimb motor dysfunction in rats

This study shows that damage to the entopeduncular nucleus in rats causes motor dysfunction, with motor recovery correlating with neuron preservation.

Modulation of temporal prediction by STN-DBS in Parkinson's disease: Links between behavior and cortical oscillations

This study examines how STN-DBS affects temporal prediction in Parkinson's disease patients, showing improved performance and changes in beta and delta oscillations.

NAc-DBS selectively enhances memory updating without effect on retrieval

This study shows that NAc-DBS enhances long-term memory encoding without affecting memory recall or working memory in rats.

Comparative molecular mapping reveals molecular gradients and spatially organized populations in the subthalamic and para-subthalamic regions

The paper maps molecular gradients and spatial organization in the subthalamic and para-subthalamic regions across species, identifying conserved and species-specific patterns.

Somatosensory rhythms and cerebellar-basal ganglia beta-band dynamics in Parkinson's disease

This study examines beta-band neural dynamics in Parkinson's disease patients and controls during a somatosensory timing task, finding altered cerebellar and basal ganglia activity and connectivity.

Characterizing the frequency-specific and spatiotemporal dynamics of β-γ Phase-Amplitude Coupling in Parkinson's disease

This study investigates β-γ phase-amplitude coupling in Parkinson's disease using EEG, finding frequency-specific increases in high β-γ PAC linked to motor symptoms and responsive to medication.