Neurological disorders and treatments

This case study examines how lower-limb dystonia affects a professional drummer's performance and muscle activity during specific drumming tasks.

This study optimises intrastriatal deep brain stimulation by using a biophysical network model to align activity patterns with healthy states.

This study reports that CT-DBS in awake mice can induce SWDs at low currents during titration, highlighting the need for EEG monitoring.

SAFE-OPT is a Bayesian optimization algorithm that incorporates safety constraints to find optimal deep brain stimulation parameters without harmful side-effects, validated in rodent studies.

This study shows that movement-related increases in subthalamic nucleus activity enhance locomotion in mice, with specific effects observed in disease models.

The paper investigates how levodopa-induced dyskinesia is linked to increased activity in specific striatal direct pathway medium spiny neurons, driven by dopamine and excitatory inputs.

The paper identifies D1/D2 coexpressing striatal projection neurons as critical for modulating motor function through interactions with D1- and D2-SPNs.

This study shows that VIM-DBS enhances motor learning for fixed sequential finger movements but not for random sequences, indicating its role in thalamo-cortical motor learning.

This study uses optogenetic fMRI to identify neural circuits affected by subthalamic nucleus deep brain stimulation in Parkinson's disease, finding that GP and CPu activity mediate therapeutic effects.

The paper identifies a frequency-following response in the subthalamic nucleus using auditory stimuli, suggesting potential for non-invasive deep brain stimulation.

The paper presents a computational model that reproduces the long-term dynamics of evoked resonant neural activity (ERNA) using vesicle depletion as the key mechanism.

This study investigates the convergence of inputs from the basal ganglia, motor cortex, and cerebellum in the mouse motor thalamus using optogenetics and viral labeling.

This paper models the disruption and recovery of harmony between direct and indirect pathways in the basal ganglia in Huntington's disease using computational analysis of pathway strength ratios.

The paper quantifies the balance between direct and indirect pathways in the basal ganglia in healthy and Parkinsonian states using a competition degree metric.

This study identifies STN LFP features, including beta and gamma oscillations and the low-high power ratio, that correlate with sleep fragmentation in Parkinson's disease patients.

This study examines how auditory cues affect STN oscillatory activity during stepping in Parkinson's disease, finding differential modulation of beta and transient oscillations.

This paper proposes a model-based closed-loop DBS controller for essential tremor using EMG signals, showing it finds DBS frequencies that align with clinical studies.

This study investigates the anti-manic effects of VTA deep brain stimulation in a methamphetamine-induced mania model, showing both stimulation patterns reduce hyperlocomotion and modulate dopamine dynamics.

This study uses 3D electron microscopy to show structural changes in GABAergic pallidothalamic terminals in MPTP-treated monkeys, revealing increased terminal volume, synapse surface area, and mitochondrial volume in specific thalamic nuclei.

This study uses multi-night recordings to show that Parkinson's disease affects NREM sleep by altering cortico-basal slow wave activity and subcortical beta power, with DBS enhancing these changes and predicting spontaneous awakenings.

This study investigates the neurophysiological effects of deep brain stimulation (DBS) on prefrontal networks in limbic hubs, showing differential modulation of gamma oscillations and subject-specific responses.

This study compares DBS artefacts in MEG recordings using different DBS devices and cleaning methods, finding device-specific differences and potential spectral artefacts after cleaning.

This paper uses a computational framework to explore how combined deep brain stimulation of the STN and SNr affects cortico-subcortical networks in Parkinson's disease patients with freezing of gait.

This in-silico study predicts how Parkinson's disease alters striatal network connectivity and glutamatergic drive to striatal projection neurons.

This paper models abnormal beta oscillations in Parkinson's disease by simulating basal ganglia circuits constrained by experimental data, showing that pallidostriatal loops drive mid-beta oscillations.

The paper investigates how sensorimotor cortex and subthalamic nucleus encode unimanual and bimanual hand movements, finding that STN encodes movements for both hands and is context-sensitive, while SMC is contralaterally biased and context-insensitive.

The paper models synaptic integration in ventromedial motor thalamocortical neurons under normal and dopamine-depleted conditions, finding increased firing rates and altered responses to inhibitory inputs in dopamine-depleted states.

This study investigates the role of the subthalamic nucleus (STN) and its adjacent para-STN in behavioral avoidance using optogenetics and electrophysiology in mice.

This study tests the compatibility of telemetric LFP streaming with MEG in DBS patients, finding that Percept PC with SenSight leads generates limited interference and OPM systems are more resilient to artefacts.

This study selectively stimulates STN projection neurons in mice and shows that STN output directly controls movement parameters with high precision.