Spinal Cord Injury Research

This study investigates the effects of 2-DG on spinal neuroinflammation and respiratory function after cervical spinal cord injury in rats, finding no effect on injured rats but adverse effects in sham animals.

This paper describes an optimized protocol for long-term maintenance of mouse spinal cord organotypic slices transplanted with human neural stem cells to test cell replacement therapies for spinal cord injury.

This study examines how spinal cord injuries affect cutaneous reflexes and interlimb coordination during locomotion in cats, finding reduced mid- and long-latency reflex responses correlate with impaired balance and coordination.

This study shows that reprogramming NG2 glia after spinal cord injury leads to axonal regeneration and improved function.

This study shows that PTEN inhibition promotes partial diaphragm function recovery and axon growth in chronic cervical spinal cord injury, while PTPσ inhibition does not.

The paper evaluates the use of stereological tools to assess tissue damage and neurodegeneration after spinal cord injury and tests the efficacy of different therapeutic strategies.

The paper constructs a searchable database of RNA-Seq data from spinal cord injury experiments to enable cross-study and cross-species analysis.

This study shows that damaging intermediate gray matter in the lumbar spinal cord of rats causes long-term locomotor deficits, with machine learning confirming the link to interneuronal loss.

This study uses AAV-rg/Cre to delete PTEN in spinal pathway cells after SCI, improving forelimb motor recovery but causing late-onset pathophysiologies in mice.

This study shows that blocking CSPG production and the receptor PTPσ improves functional recovery in chronic spinal cord injury models.

This study shows that PTEN knockout via retrogradely transported AAVs can restore locomotor function in both acute and chronic spinal cord injury, but functional improvements are not sustained long-term.

This study examines how spinal cord injury affects locomotion speed and gait in rats, revealing changes in gait patterns and coordination after injury.

This study examines how adult cats negotiate obstacles after spinal cord injury, finding improved clearance over time with changes in muscle activation and weight distribution.

This study examines CST reorganization in macaques after partial spinal cord injury, showing axonal sprouting and re-direction in both rostral and caudal spinal segments contributing to recovery of finger dexterity.

This study shows that nicotinamide riboside (NR) increases NAD+ levels in the injured spinal cord, protecting tissue and improving locomotor recovery in rats.

The paper tracks functional recovery in zebrafish after spinal cord injury and identifies gait quality as a predictor of regeneration outcomes.

This study shows that multielectrode configurations of transcutaneous spinal cord stimulation improve muscle recruitment selectivity by targeting specific spinal segments.

This study uses a bi-cortical neuroprosthesis to investigate motor program recovery after spinal cord injury in cats, showing that cortical control can be re-established to modulate gait and alleviate foot drag.

This study investigates the effects of low-intensity pulsed ultrasound (LIPUS) on forelimb function recovery in rats with cervical cord injury, showing improved performance with combined LIPUS and Buspirone treatment.

Boldine improves locomotor function and reduces glial activation in a mouse model of spinal cord injury by modulating calcium signaling and gene expression.

This study shows that administering recombinant mouse mast cell protease 6 improves functional recovery after spinal cord injury by reducing demyelination and astrogliosis.

This review evaluates estrogen and estrogenic compounds' neuroprotective effects in spinal cord injury, finding they reduce inflammation and improve functional outcomes.

This study shows that delayed AAV1-NT3 injection after spinal injury improves skilled locomotion and swimming coordination in rats but not gross movement.

This study shows spinal stimulation enhances or suppresses muscle activity during voluntary torque tasks in monkeys, depending on torque direction and voluntary muscle activity levels.

The paper uses single-cell RNA sequencing to identify immune cell populations and interactions in mouse spinal cord injury, revealing microglial and B cell heterogeneity and crosstalk.

This study develops spinal cord associative plasticity (SCAP) to enhance sensorimotor function after cervical spinal cord injury by pairing motor cortex and spinal cord stimulations, showing improved dexterity and reflex modulation.