Olfactory and Sensory Function Studies

Olfactory marker protein regulates refinement of the glomerular map

This study shows that OMP deletion leads to functional and anatomical heterogeneity in olfactory glomeruli due to anomalous co-innervation by OSNs with different ORs.

Interspecific variation of olfactory preferences in flies, mice, and humans

The paper compares olfactory preferences across flies, mice, and humans, finding positive correlation between flies and mice, negative correlation between flies and humans, and no evidence of shared preferences between humans and mice.

DeepNose: Using artificial neural networks to represent the space of odorants

This paper trains an autoencoder to represent odorant chemical space and uses it to predict human olfactory percepts with accuracy comparable to traditional molecular descriptors.

Sniff invariant odor coding

The paper shows that odor concentration discrimination is independent of sniff frequency, and a fluid dynamics model explains variability in MT cell responses, enabling sniff-invariant coding.

State-dependent changes in olfactory cortical networks via cholinergic modulation

The paper investigates state-dependent changes in olfactory cortical networks by examining the balance of bottom-up and top-down synaptic inputs in freely moving rats.

Complement 3 signaling is necessary for the developmental refinement of olfactory bulb circuitry

This study shows that complement 3 signaling via CR3 is necessary for the proper development and refinement of olfactory bulb maps.

Recurrent cortical circuits implement concentration-invariant odor coding

The paper shows that recurrent cortical circuits maintain odor identity coding despite concentration changes by suppressing concentration-dependent inputs.

Sniff-invariant intensity perception using olfactory bulb coding of inhalation dynamics

The paper shows that mice use olfactory bulb mitral and tufted cells to encode inhalation dynamics, enabling odor intensity perception independent of sniffing variability.

Rapid olfactory discrimination learning in adult zebrafish

This study develops an automated odor discrimination task for adult zebrafish, showing they can rapidly learn fine odor discriminations through conditioned feeding behavior.

Single olfactory receptors set odor detection thresholds

The paper shows that single olfactory receptors, specifically TAARs, set odor detection thresholds in mice, with sensitivity determined by the most sensitive receptor.

Calcium-activated chloride channels clamp odor-evoked spike activity in olfactory receptor neurons

This study shows that Ano2 clamps odor-evoked spike activity in olfactory receptor neurons in vivo, despite reduced transduction currents in Ano2-/- mice.

Unique molecular markers for GC-D-expressing olfactory sensory neurons and chemosensory neurons of the Grueneberg ganglion

The paper identifies unique molecular markers for GC-D+ olfactory sensory neurons and Grueneberg ganglion chemosensory neurons and their target glomeruli in mice.

Thresholding of sensory inputs by extrasynaptic glutamate receptors in olfactory bulb glomeruli

The paper demonstrates that extrasynaptic glutamatergic signaling in olfactory bulb glomeruli creates a thresholding effect by balancing excitation and inhibition, allowing only strong stimuli to produce an output.

Computational algorithms and neural circuitry for compressed sensing in the mammalian main olfactory bulb

The paper proposes a compressed sensing algorithm in the mammalian main olfactory bulb using computational modeling and electrophysiological data, showing it can efficiently represent odors and adapt to odor mixtures.

Active sampling state dynamically enhances olfactory bulb odor representation

The paper shows that active sampling state enhances odor representation in the olfactory bulb during rapid learning.

Pharmacological manipulation of olfactory bulb granule cell excitability modulates beta oscillations: Testing a model

The paper tests a model predicting that granule cell excitability drives beta oscillations in the olfactory bulb through voltage-dependent calcium channels, using pharmacological manipulations.

Cytokine profile in human olfactory cleft mucus and associated changes in olfactory function

The paper investigates age-related olfactory loss by analyzing cytokine levels in human olfactory mucus and their association with olfactory function decline.

Predicting natural language descriptions of smells

The paper predicts perceptual ratings for odorants using natural language semantics and chemoinformatic features, achieving higher accuracy for more descriptors than previous methods.

Implications for human odor sensing revealed from the statistics of odorant-receptor interactions

The paper analyzes odorant-receptor interactions using a kinetic model to characterize OR activation statistics and their implications for odor perception.

A Near Complete Zonal Map of Mouse Olfactory Receptors

The paper maps zonal expression of olfactory receptors in mouse MOE using mRNA sequencing, identifying zones for 1,033 OR genes with high coverage and accuracy.

Antagonism in olfactory receptor neurons and its implications for the perception of odor mixtures

The paper models how mammalian olfactory receptor neurons process odor mixtures, showing antagonistic interactions lead to normalization of glomerular responses and improve odor discrimination.

Olfactory fear conditioning non-specifically enhances glomerular odor responses and increases representational overlap of learned and neutral odors

This study shows that olfactory fear conditioning enhances glomerular odor responses and increases similarity between learned and neutral odors, potentially promoting fear generalization.

Stimulus Dependent Diversity And Stereotypy In The Output Of An Olfactory Functional Unit

The paper shows that sister MT cells in a glomerulus exhibit diverse or stereotyped responses to odorants, with stereotypy linked to ligand affinity regardless of concentration.

A Transformation From Latency To Ensemble Coding In A Model Of Piriform Cortex

The paper models how piriform cortex transforms temporal latency coding from the olfactory bulb into ensemble coding, showing robust odor representation across concentration changes.

Inhalation frequency controls reformatting of mitral/tufted cell odor representations in the olfactory bulb

The paper investigates how inhalation frequency affects odor representations in mitral/tufted cells of the olfactory bulb, finding frequency-dependent changes in neural activity patterns.

Shared Genetic Requirements for Atf5 Translation in the Vomeronasal Organ and Main Olfactory Epithelium

This study identifies shared genetic requirements for ATF5 translation in vomeronasal and olfactory sensory neurons, showing similar regulation by the unfolded protein response.

Selective attention controls olfaction in rodents

This study shows that rats can selectively attend to odors amidst competing stimuli, improving odor-guided decisions and sharpening neural representations of odors.

A cortical pathway modulates sensory input into the olfactory striatum

This study investigates the functional role of the cortico-striatal pathway from the piriform cortex to the olfactory tubercle in mice, showing it modulates odor coding through monosynaptic connections.

Concentration invariant odor coding

The paper identifies a concentration-invariant odor coding mechanism based on early receptor activation and demonstrates its role in odor identification through behavioral and neural experiments.

SMELL-S and SMELL-R: olfactory tests not influenced by odor-specific insensitivity or prior olfactory experience

The paper introduces SMELL-S and SMELL-R, olfactory tests that reduce bias from odor-specific insensitivity and prior experience by using unfamiliar odorant mixtures, showing high reliability across populations.