Olfactory and Sensory Function Studies

Primacy coding facilitates effective odor discrimination when receptor sensitivities are tuned

This paper develops a model of primacy coding in olfaction, showing it enables effective odor discrimination and connects receptor properties to system performance.

Scaling principles of distributed circuits

The paper investigates the scalability of distributed circuits, finding the olfactory circuit meets three criteria of scalability across six mammals.

Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium

The paper examines mucin expression differences between olfactory and respiratory epithelium in mice and finds no radiation-induced changes in mucin expression after 8 Gy exposure.

A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans

This study creates a transcriptomic atlas of olfactory mucosae across species to show evolutionary patterns in odor detection capabilities.

Interneuron functional diversity in the mouse accessory olfactory bulb

The paper investigates functional diversity of inhibitory interneurons in the mouse accessory olfactory bulb using electrophysiological recordings and genetic labeling.

Modular structure of human olfactory receptor codes reflects the bases of odor perception

The paper shows that human olfactory receptor codes have a modular structure reflecting key olfactory features in odor perception.

GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice

The paper identifies a novel GABAergic neuron population in the olfactory cortex of mice that project to the lateral hypothalamus and integrate olfactory and top-down inputs.

Screening performance of abbreviated versions of the UPSIT smell test

The paper evaluates abbreviated versions of the UPSIT smell test to detect hyposmia, finding that a 4-item test outperforms existing shorter versions in sensitivity and specificity.

Temporal dynamics of inhalation-linked activity across defined subpopulations of mouse olfactory bulb neurons imaged in vivo.

The paper examines inhalation-linked activity dynamics in mouse olfactory bulb neurons using in vivo calcium imaging, revealing distinct temporal patterns across cell types.

Genetic variation across the human olfactory receptor repertoire alters odor perception

The paper investigates how genetic variation in olfactory receptors affects odor perception by analyzing sequencing data and phenotypes from 332 individuals.

A competitive binding model predicts nonlinear responses of olfactory receptors to complex mixtures

The paper develops a competitive binding model to predict olfactory receptor responses to complex odorant mixtures, achieving 15% accuracy using single-odorant responses.

Basal forebrain GABAergic innervation of olfactory bulb periglomerular interneurons

This study investigates basal forebrain GABAergic projections to olfactory bulb interneurons, revealing distinct synaptic inputs to different periglomerular cell subtypes and their roles in inhibitory circuits.

Sensitivity of Olfactory Sensory Neurons to food cues is tuned to nutritional states by Neuropeptide Y signalling

This study shows that neuropeptide Y signaling in zebrafish modulates olfactory sensory neuron sensitivity to food-related cues based on nutritional state.

Opposing roles of dopamine receptor D1- and D2-expressing neurons in the anteromedial olfactory tubercle in acquisition of place preference in mice

This study shows that D1 and D2 neurons in the anteromedial olfactory tubercle of mice have opposing roles in mediating attractive and aversive behaviors during place preference tests.

The optimal odor-receptor interaction network is sparse in olfactory systems: Compressed sensing by nonlinear neurons with a finite dynamic range

The paper shows that the optimal odor-receptor interaction network is sparse and follows a log-normal distribution, enhancing decoding accuracy in olfactory systems.

Mammalian olfaction is a high temporal bandwidth sense

The paper demonstrates that mammals can perceive temporal structure in odour stimuli at fast timescales, using a novel odour delivery system and behavioural experiments with mice.

AutonoMouse: High throughput automated operant conditioning shows progressive behavioural impairment with graded olfactory bulb lesions.

The paper introduces an automated system for high-throughput operant conditioning in mice and uses it to study the effects of olfactory bulb lesions on behavior.

Bioisosterism reveals new structure-odor relationships

The paper explores structure-odor relationships by testing odorants in mice, showing that OSN responses better reflect perceptual classifications than chemical descriptors.

Adaptation of olfactory receptor abundances for efficient coding

The paper explains how olfactory receptor abundances adapt to efficiently encode odor information, showing context-dependent changes predicted by efficient coding theory.

Rapid task-dependent tuning of the mouse olfactory bulb

This study shows the mouse olfactory bulb dynamically modulates neural responses based on stimulus tuning to enhance discriminability under different behavioural demands.

Coordinated electrical activity in the olfactory bulb gates the oscillatory entrainment of entorhinal networks in neonatal mice

The paper shows that olfactory bulb activity coordinates with entorhinal circuits in neonatal mice through theta bursts and odor exposure.

Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction

The paper develops a computational model of olfactory network rewiring and predicts how top-down inputs enhance sensory processing through granule cell plasticity.

A novel olfactometer for efficient and flexible odorant delivery

This paper introduces a novel olfactometer that efficiently and flexibly delivers odorants with high temporal precision and no contamination, enabling precise mapping of odorants to neural activity.

Narrowly confined and glomerulus-specific onset latencies of odor-evoked calcium transients in the periglomerular cells of the mouse main olfactory bulb

This study measures odor-evoked calcium transients in mouse periglomerular cells and finds that onset latencies are narrowly confined within glomerulus-specific groups.

Odorant receptor inhibition is fundamental to odor encoding

The paper investigates how odorant receptor inhibition shapes neuronal responses to complex odors and finds that OR antagonism, inverse agonism, and partial agonism are common and combinatorial in olfactory sensory neurons.

Context-dependent decision making in a premotor circuit

The paper investigates how context influences olfactory decision-making by examining the role of the premotor area ALM in a delayed match-to-sample task.

The Ca2+-activated Cl- current ensures robust and reliable signal amplification in vertebrate olfactory receptor neurons

The paper shows that Cl- efflux, not Na+ influx, provides a more reliable and robust signal amplification mechanism in vertebrate olfactory receptor neurons.

Respiration-phased switching between sensory inputs and top-down inputs in the olfactory cortex

The paper investigates how olfactory cortex pyramidal cells switch between processing sensory and top-down inputs based on respiration phases, revealing distinct current patterns in different layers during inhalation and exhalation.

Molecular Nearest Neighbors Determine Generalization of Odorant Mixtures

The paper investigates how mice generalize responses to odorant mixtures by testing models that predict perceptual similarity based on molecular nearest neighbors.

Retronasal Habituation: Characterization and Impact on Flavor Perception using Time-Intensity

This study characterizes retronasal olfactory habituation and its impact on flavor perception through two experiments with food and non-food odors.