Viral gastroenteritis research and epidemiology

Gut-resident C. perfringens impedes rotavirus vaccine efficacy

The paper investigates how gut microbiota, particularly C. perfringens, affects rotavirus vaccine efficacy in mice and human children.

Purinergic Signaling Drives Multiple Aspects of Rotavirus Pathophysiology

This study shows that blocking P2Y1 receptors reduces rotavirus-induced diarrhea and viral shedding in mice, suggesting P2Y1 signaling promotes disease.

Long Amplicon Nanopore Sequencing for Dual-Typing RdRp and VP1 Genes of Norovirus Genogroups I and II in Wastewater

This paper develops a long amplicon nanopore sequencing method for dual-typing RdRp and VP1 genes of norovirus in wastewater, revealing diverse genotypes and potential for improved epidemiological tracking.

Genetic Susceptibility to Astrovirus Diarrhea in Bangladeshi Infants

This study identifies two genetic regions associated with astrovirus diarrhea susceptibility in Bangladeshi infants through a genome-wide association study.

Metagenomic detection and genetic characterization of human sapovirus among children in Nigeria

The paper identifies and characterizes Sapovirus genetic diversity in Nigerian children with Acute Flaccid Paralysis using metagenomic sequencing.

Glycochenodeoxycholic acid and ceramide suppress the antiviral effect of 25-hydroxycholesterol against human norovirus infection in human intestinal enteroids

The paper shows that GCDCA and ceramide reduce the antiviral effect of 25-HC against norovirus in HIE, with 25-HC suppressing viral replication and altering gene expression related to cholesterol and interferon pathways.

Asymmetric Reconstruction of the Aquareovirus Core at Near-Atomic Resolution and Mechanism of Transcriptional Initiation

The paper presents the near-atomic structure of the aquareovirus core and reveals structural differences that suggest a mechanism for transcription initiation in multilayered reoviruses.

DETECTION AND MOLECULAR CHARACTERIZATION OF ROTAVIRUS AND PICOBIRNAVIRUS IN WILD AVIANS FROM AMAZON FOREST

The paper detects and characterizes rotavirus and picobirnavirus in wild birds from Brazil, identifying multiple genotypes and reporting interspecies transmission potential.

New Insights Into the Effect of Residue Mutation on the Rotavirus VP1 Function Using Molecular Dynamic Simulations

The paper uses molecular dynamic simulations to analyze VP1 mutants of Rotavirus group A, revealing structural changes that may affect viral replication and vaccine effectiveness.

Nanobody mediated neutralization reveals an Achilles heel for norovirus

This paper identifies and analyzes two types of neutralizing Nanobodies against murine norovirus, revealing structural vulnerabilities in the capsid that could inform antiviral development.

In situ structure of rotavirus VP1 RNA-dependent RNA polymerase

The paper determines the in situ structure of rotavirus VP1 RNA-dependent RNA polymerase using local reconstruction, showing conformational changes during transcription and stochastic distribution of VP1 molecules.

Heterologous Expression of Human Norovirus GII.4 VP1 Leads to Assembly of T=4 Virus-Like Particles

The paper determines the cryo-EM structure of GII.4 norovirus VLPs and finds they exhibit T=4 symmetry, with structural and antigenic differences compared to T=3 VLPs.

Human Norovirus Neutralized by a Monoclonal Antibody Targeting the HBGA Pocket

This paper shows that a monoclonal antibody (10E9) blocks norovirus by competing with HBGA binding and neutralizes virus in cell culture, despite antigenic drift in GII.4 variants.

Prospective real-time metagenomic sequencing during norovirus outbreak reveals discrete transmission clusters

This study uses real-time metagenomic sequencing during a norovirus outbreak to identify transmission clusters and ongoing viral shedding in a hospital setting.