Viral gastroenteritis research and epidemiology

In silico codon optimization and phylogenetic analysis of various strains of Sapovirus

The paper optimizes codon usage for Sapovirus VP1 and VP2 genes in Escherichia coli and performs phylogenetic analysis of twelve human strains.

Ursolic Acid Inhibits Rotavirus Replication Through Modulation Of Lipid Droplet Homeostasis

This study shows that ursolic acid inhibits rotavirus replication by disrupting lipid droplet homeostasis through both impaired biogenesis and accelerated degradation.

Evaluation of Human Norovirus Replication in Salivary Gland Cells

This study evaluates the replication of human norovirus in salivary gland cells and finds limited replication of certain isolates despite testing various supplements and inhibitors.

NoroScope: Exploring the Mutational Landscape of the Human Norovirus Capsid Protein with Context-Aware Machine Learning

NoroScope uses context-aware machine learning to prioritize amino-acid substitutions in the norovirus capsid protein, achieving high precision in predicting mutation effects with limited data.

Plscr1 inhibits murine norovirus entry

This study identifies Plscr1 as a restriction factor for murine norovirus, showing it inhibits infection through a post-attachment entry step.

Selective Packaging of Rotavirus Double-Layered Particles into Host Microvesicles

This study shows rotavirus uses host microvesicles to transmit immature double-layered particles, enabling non-lytic spread and bypassing outer-capsid-dependent entry.

Development of fluorescent and affinity tagged variants of rotavirus nonstructural protein 4 using the reverse genetics system

This paper develops fluorescent and affinity-tagged rotavirus NSP4 variants using reverse genetics to study its function during infection.

Phylogenetic network reconstruction reveals reassortment signatures at segment and genotype levels in human Rotavirus A

This study uses Bayesian phylogenetic networks to analyze reassortment patterns in human Rotavirus A segments, finding changes in reassortment rates and genotype compatibility over time.

Enhanced inter-chain hydrogen bonding in the murine norovirus VP1 capsid leads to increased particle stability and delayed viral uncoating

Symptomatic human norovirus infection in zebrafish embryos uncovers neural infection and extracellular vesicle-mediated transmission dynamics

This paper establishes a zebrafish embryo model of symptomatic human norovirus infection, revealing neural tropism and age-dependent extracellular vesicle-mediated transmission.

Near-atomic structures of human astrovirus capsids reveal a subunit-specific maturation mechanism

The paper reports near-atomic cryo-EM structures of human astrovirus serotype 4 in immature and mature states, revealing a subunit-specific maturation mechanism driven by protease accessibility.

Inhibition of VP2-mediated entry: a potential antiviral strategy to treat or prevent calicivirus disease

This study demonstrates that inhibiting VP2-mediated entry reduces calicivirus infectivity, suggesting a potential antiviral strategy for treating norovirus disease.

Human enterochromaffin cells and apical-out intestinal organoids as models for human sapovirus infection

This study compares four in vitro models for sapovirus infection using clinical samples, identifying GOT1 cells and apical-out enteroids as effective models for virus replication.

Comparison of Human Intestinal Enteroids and Zebrafish Larvae models for replication of Human Norovirus

This study compares the replication of human norovirus in human intestinal enteroids and zebrafish larvae models using clinical stool specimens, finding genotype-specific replication efficiency differences.

A comprehensive evaluation of ultraviolet irradiation at 254 nm and 222 nm in inactivating human noroviruses on surfaces

This study evaluates the effectiveness of UV 222 and UV 254 in inactivating human noroviruses and surrogates on surfaces, finding UV 222 more effective in reducing infectivity and viral capsid damage.

Signal peptidase complex mediates rotavirus VP7 processing and virion assembly

This study identifies the signal peptidase complex (SPC) as essential for rotavirus VP7 processing and virion assembly, showing that SPC cleavage of VP7's signal peptide is critical for infectious particle formation.

Microbiota-derived indole metabolites inhibit rotavirus infection in vitro and in vivo and in human infants

This study shows microbiota-derived indole metabolites inhibit rotavirus infection in human infants and animal models through the AhR pathway.

Development of an ex vivo model to study the zoonotic transmission of noroviruses

This study develops an ex vivo model to investigate zoonotic transmission of noroviruses, showing human norovirus can bind and replicate in pig tissue but not chicken tissue.

Polyamine depletion inhibits norovirus infection by blocking virus-induced apoptosis

This study shows polyamine depletion inhibits norovirus infection by blocking virus-induced apoptosis and virion release in both human and murine systems.

Releasing RNA from formalin: novel 20th century rotavirus alphagastroenteritidis strains identified in Australian microbat voucher specimens

The paper identifies novel Rotavirus alphagastroenteritidis strains in Australian microbat specimens preserved for up to 60 years, demonstrating the feasibility of recovering viral RNA from formalin-fixed samples.

Phosphorylation enables allosteric control of a viral condensate

This study shows that phosphorylation enables distinct nucleation mechanisms for NSP5 condensate formation in rotaviruses, depending on strain-specific LLPS propensity.

Overcoming host restrictions to enable continuous passaging of human noroviruses in human intestinal enteroids

This study identifies host restriction factors limiting HuNoV passaging in HIEs and demonstrates that TAK-779 enhances viral replication and enables continuous passaging.

Virion encapsidation and cell attachment function of the reovirus attachment protein is influenced by its structural flexibility

This study models the structure of reovirus {sigma}1 proteins and shows that flexibility in the head-body domain affects their incorporation into virions and receptor binding.

Evaluation of anti-noroviral compounds on human norovirus replication using 2D monolayers of human intestinal organoids

The paper evaluates anti-noroviral compounds in 2D human intestinal organoid monolayers and finds lower antiviral activity compared to 3D apical-out organoids.

Detection of Infectious Murine Norovirus on Fresh Produce through a Novel CRISPR/Cas13-based Sensitive Assay

This study develops a CRISPR/Cas13-based assay to detect infectious murine norovirus in food samples, showing higher sensitivity than RT-qPCR for low copy numbers.

Deciphering the role of histo-blood group antigens in bovine rotavirus C infection

This study identifies how a bovine rotavirus C strain binds H2 and LacNAc through structural and biochemical analysis, revealing genotype-specific glycan recognition mechanisms.

Mechanisms of maternal antibody interference to rotavirus vaccination

This study investigates how maternal antibodies interfere with rotavirus vaccination in neonates using a mouse model, finding that vaccine clearance rather than FcγRIIB signaling or epitope masking is the main mechanism of interference.

The Orai channel inhibitor BTP2 restricts Tulane virus and human norovirus replication independent of store-operated calcium entry

This study shows that BTP2 inhibits Tulane virus and human norovirus replication by targeting structural proteins, not through SOCE, and establishes a system for antiviral screening.

NMR Reveals the Synergistic Roles of Bivalent Metal Ions in Norovirus Infections

The paper uses NMR to show that bivalent metal ions synergistically interact with norovirus P-domains, affecting capsid conformation and infectivity, but with differences between murine and human noroviruses.

Gut-resident C. perfringens impedes rotavirus vaccine efficacy

The paper investigates how gut microbiota, particularly C. perfringens, affects rotavirus vaccine efficacy in mice and human children.