Sleep and Wakefulness Research

A Neuroimmune Feedforward Circuit Linking REM Sleep with Stress-Related Behavioral Susceptibility

This study identifies a neuroimmune circuit linking chronic stress, REM sleep, and behavioral susceptibility through monocyte-driven microglial remodeling and PV neuron activity.

Shared Transcriptomic Responses Across Distinct Sleep-Wake Manipulations Reveals Multiple Homeostatic Pathways in Drosophila

The paper identifies genes involved in sleep homeostasis in Drosophila by analyzing transcriptomic responses across multiple sleep-wake manipulation methods and datasets.

Hypothalamic MCH neurons links tau pathology to sleep disruption

This study identifies MCH neurons in the hypothalamus as a key circuit linking tau pathology to sleep disruption and shows their potential as a therapeutic target.

Closed-loop auditory stimulation during sleep shapes cortical responses and memory consolidation depending on spindle timing

This study shows that timing of auditory stimulation during sleep affects spindle dynamics and memory consolidation, with post-spindle stimulation improving motor memory but not word recall.

Sex-specific roles for yawning in the Emperor cichlid Boulengerochromis microlepis

This study examines yawn functions in juvenile Emperor cichlids, finding support for arousal, social contagion, and sex-specific differences in yawn timing and frequency.

Cardiovascular responses to natural and auditory evoked slow waves predict post-sleep cardiac function

This study examines how natural and auditory-evoked slow waves affect cardiovascular function after sleep, finding that synchronized type I slow waves are linked to cardiovascular responses.

No evidence for sleep-dependent memory generalization in a large online sample

This study investigates whether sleep enhances memory generalization using an online sample and finds no evidence supporting a role for sleep in promoting this process.

A hypothalamic-brainstem activity sequence underlies arousal fluctuations during daytime drowsiness

The paper identifies a hypothalamic-brainstem activity sequence that drives arousal fluctuations and cortical hemodynamics during drowsiness using fMRI.

Thalamic oscillations distinguish natural states of consciousness in humans

The paper identifies a 19-45 Hz thalamic oscillation specific to REM sleep and wakefulness, distinguishing conscious states in humans.

How Awakenings Shape Dream Recall: A Multilevel Study

This study investigates how nocturnal awakenings influence dream recall, finding that specific awakening characteristics, not just frequency, affect different types of dream recall.

Subcortical recruitment dissociates isoflurane emergence from distinct wakeful states in mice

The paper maps whole-brain neural activity during emergence from isoflurane anesthesia in mice and finds selective subcortical activation rather than global cortical reactivation.

Sleep Preserves, Wake Differentiates: Strength-Dependent Forgetting of Declarative Memories Across the Retention Interval

This study shows sleep preserves declarative memories regardless of initial strength, while wakefulness selectively impairs weak memories.

A screen for stress-induced sleep genes in C. elegans reveals a role for glutamate signaling

The paper identifies genes involved in stress-induced sleep in C. elegans, highlighting the role of glutamate signaling in sleep regulation.

Respiratory pauses highlight sleep architecture in mice

The paper shows respiratory pauses distinguish sleep states in mice and reveal sleep architecture through respiration.

Spatial memory performance is associated with region-specific coordination of hippocampo-cortical sleep oscillations

The paper examines how coordination of sleep oscillations during nREM sleep relates to spatial memory performance in rats, finding region-specific coupling patterns between hippocampal and cortical areas.

Time Restricted Feeding Mitigates High-Fat-Diet Induced Sleep Disruption and Amplifies NREM Substates

This study uses EEG/EMG recordings and machine learning to analyze how time-restricted feeding affects sleep microarchitecture in mice on a high-fat diet, finding it reduces sleep fragmentation and enhances specific NREM substates.

Sleep loss overrides sleep-preparatory behavior to promote sleep

This study investigates how sleep loss affects pre-sleep behaviors in mice, finding that sleep deprivation suppresses nest-building and promotes direct sleep onset.

Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidation in Middle-Aged and Older Adults

This study examines longitudinal changes in sleep EEG biomarkers of memory consolidation in middle-aged and older adults, finding declines in SO-sigma coupling and sleep spindle measures linked to synaptic integrity and memory decline.

Ramelteon facilitates hippocampal ripple occurrence and amplitude in mice

This study shows that ramelteon increases hippocampal ripple occurrence and amplitude during NREM sleep in mice, potentially supporting its cognitive-enhancing effects.

Sleep Spindle-Locked Targeted Memory Reactivation Enhances Declarative Memory Consolidation

This study shows that targeted memory reactivation during sleep spindles improves recall-based memory retention, with spindle temporal clustering affecting different memory outcomes.

Shared local brain dynamics in pediatric and adult NREM parasomnias

This study identifies shared neurophysiological patterns in pediatric and adult non-rapid eye movement parasomnias using EEG and source-space analysis.

Theta-band brain synchronization supports the immediate and post-sleep dynamics of memory recall in children

The paper investigates how theta-band brain synchronization during immediate and post-sleep recall sessions in children supports memory recall dynamics and performance.

stk32a links sleep homeostasis to suppression of sensory and motor systems

This study identifies stk32a as a conserved sleep regulator that links neuropeptidergic signaling to sleep homeostasis by suppressing sensory and motor systems in zebrafish and mice.

JACUZI-SD: An automated, high-throughput, minimally stressful approach to sleep depriving larval zebrafish.

JACUZI-SD is a method to induce sleep deprivation in larval zebrafish with minimal stress, reducing total sleep time by 41-64% and eliciting rebound sleep.

Learning the bistable cortical dynamics of the sleep-onset period

The paper introduces a stochastic dynamical model to capture bistable dynamics during sleep onset and shows its parameters correlate with subjective sleepiness reports.

The semantics of dreams

This study analyzes dream content using a multimodal dataset to show how individual traits and external events shape dream experiences.

Twitching in sleeping premature infants provides a sensitive behavioral assay of early motor control

The paper systematically characterizes limb twitching in preterm infants to assess early motor control during sleep.

The developmental emergence of tonic and phasic REM sleep in rats

This study examines the developmental emergence of tonic and phasic REM sleep in rats, showing sequential differentiation of REM substates with age-dependent changes in neural activity and oscillations.

Hippocampus consolidates memory in the upstate of cortical sleep slow oscillations

This study inhibits hippocampal activity during specific sleep phases in rats and shows that memory consolidation requires hippocampal engagement during cortical slow oscillation upstates.

Bidirectional restoration of sleep homeostasis in neurodegeneration via closed-loop auditory stimulation

This study shows that closed-loop auditory stimulation can restore sleep homeostasis in Alzheimer's and Parkinson's disease models by modulating cortical synchrony and arousal.