Sleep and Wakefulness Research

EEG Microstates reveal distinct network dynamics in lucid and non-lucid REM sleep

The paper analyzes EEG microstate dynamics in lucid versus non-lucid REM sleep, finding distinct microstate patterns associated with different cognitive and emotional functions.

Memory reactivation during sleep promotes structure abstraction

This study shows that memory reactivation during sleep promotes structural abstraction, enabling knowledge transfer between categories with no feature overlap.

Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep

The paper identifies cell-type-specific genes regulating sleep by mapping GWAS variants to effector genes in human and Drosophila models, revealing ruby/AP3B2 as a conserved glial regulator.

NREM Oscillations Mediate Synaptic Proteome Remodelling to Support Synapse Stabilisation

The paper shows that NREM sleep oscillations drive synaptic proteome remodelling, promoting stabilization and memory consolidation, while altered oscillations in a disorder lead to synaptic weakening.

Thalamic involvement defines distinct slow-wave subtypes in NREM sleep

The paper identifies two distinct slow-wave subtypes in NREM sleep based on thalamic involvement and synchronization mechanisms using EEG-fMRI data.

Decomposing representational drift across wake and sleep

This study decomposes representational drift in mice olfactory cortex during wake and sleep, showing distinct transformations driven by each state.

Sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.

This study identifies a subset of hippocampal CA1 pyramidal neurons that are selectively reactivated by repeated sleep deprivation and shows associated molecular changes.

Vgll2 and Tead1 Govern Generation of Mouse and Human Hypothalamic Hypocretin (Orexin) Neurons

This paper identifies Vgll2 and Tead1 as key regulators of Hcrt neuron generation in mouse and human, showing their role in differentiation and potential for cell therapy.

Sleep and emotional memory: translating neural response at encoding to memory accuracy in men and women with and without PTSD

The paper examines how sleep stages and PTSD status affect emotional memory accuracy through neural responses to visual stimuli in men and women.

Chronic short sleep in early life accelerates cognitive decline via disrupted proteostasis

This study shows that chronic short sleep in early life accelerates cognitive decline by disrupting proteostasis and increasing neuroinflammation in mice.

Long Wake/Short Sleep Bouts and Hyperactivity with Advanced Age in a Mouse Model of Early Onset Alzheimers Disease

This paper investigates sleep and activity patterns in a mouse model of early onset Alzheimer's disease, finding a long wake/short sleep phenotype more pronounced in females.

Resolving the Deep Sleep Dual Indeterminacy Problem: Context-Dependent Slow-Wave Activity Modeling Predicts Neurobehavioral Fatigue Where Clinical Sleep Modeling Fails

The paper shows that slow-wave activity (SWA) predicts neurobehavioral fatigue differently during sleep and wakefulness, outperforming clinical sleep metrics in modeling recovery from sleep deprivation.

Waking Up in the Dream Lab: A Lab-Based Lucid Dream Induction Paradigm Using Virtual Reality and Sensory Stimulation

This paper investigates lucid dream induction using virtual reality and sensory stimulation in a lab setting, finding that explicit context training is more effective than additional technological interventions.

Immersive NREM dreaming preserves subjective sleep depth against declining sleep pressure

This study examines how immersive NREM dreaming affects perceived sleep depth despite declining sleep pressure.

Sleep deprivation impairs information processing via dysregulation of chloride homeostasis in the prefrontal cortex

This study shows sleep deprivation impairs information processing in the prefrontal cortex by disrupting chloride homeostasis through KCC2 reduction and BDNF-TrkB signaling, which can be mitigated by bumetanide or AP synthesis blockade.

Sensory processing reallocation from external to internal signals in REM sleep

The paper examines how neural responses to external and internal signals shift during different REM sleep states, finding increased internal signal processing in phasic REM.

Increased numbers of CD4+ T-cells in hypocretin/orexin region of Narcolepsy Type 1

The paper identifies an 11-fold increase in CD4+ T-cells in the hypocretin region of NT1 brains, correlating with symptom severity.

Dream content and slow waves benefit preys against predators in a video game confrontation

The paper shows that prey-like individuals in a video game show improved performance after sleep with more slow waves and game-related dreams.

Reactivating conflicting evaluative memories during sleep reduces decision ambivalence

This study shows that reactivating conflicting memories during sleep reduces decision ambivalence by integrating them, as evidenced by behavioral and electrophysiological measures.

Balancing Lucidity: Muscle and Vestibular Stimulation for Lucid Dream Induction

This study investigates whether muscle and vestibular stimulation can induce lucid dreams, finding that galvanic vestibular stimulation increases dream lucidity while muscle stimulation does not.

Hypothalamic Orexin Input to the Medial Amygdala Links Vigilance to Arousal

This study identifies a hypothalamic orexin pathway to the medial amygdala that links anesthetic state transitions to vigilance behaviors.

Depression symptoms are associated with affective neural processing during sleep and rest

The paper shows that re-emerging negative neural patterns during sleep and rest predict higher depressive symptoms.

Sleep neural code perpetuates the evolving negativity bias under stress

The paper shows that sleep helps maintain negativity bias after stress by shaping neural representations during sleep.

Memory transfer unfolds through rapid shifts in memory stability states during sleep in humans

The paper shows that memory transfer between declarative and procedural systems occurs through rapid stability shifts during NREM and REM sleep in humans.

Tracing infant sleep neurophysiology longitudinally from 3 to 6 months: EEG insights into brain development

This study tracks EEG changes in infant sleep from 3 to 6 months, showing regional and frequency-specific maturation patterns linked to developmental outcomes.

Optogenetic Modeling of Wake-Like Transcriptional Progression in Human SH-SY5Y Neuronal Cells

This study uses optogenetic stimulation to show that sustained neuronal excitation in human SH-SY5Y cells generates staged, wake-like transcriptional progression through distinct temporal gene modules.

Sleep Deprivation Alters Hippocampal Dendritic Spines in a Contextual Fear Memory Engram

The paper investigates how sleep deprivation affects dendritic spine density in neurons encoding contextual fear memories, finding reduced spine density in sleep-deprived mice.

How sleeping minds decide: state-specific reconfigurations of lexical decision-making

This study uses computational modeling to show how lexical decision-making adapts across different sleep states, revealing state-specific changes in cognitive processing strategies.

Sleep deprivation following hippocampus-dependent learning downscales synaptic inputs to lateral and medial entorhinal cortex interneurons

This study examines how brief sleep deprivation after learning affects synaptic structures of SST+ interneurons in the entorhinal cortex, revealing subregion-specific changes in dendritic spines and excitatory/inhibitory balance.

Delayed, Reduced and Redundant: Information Processing of Prediction Errors during Sleep

The paper analyzes prediction error processing during sleep using information-theoretic methods, finding reduced and redundant neural information with deeper sleep and REM.